Navigation Links
Small worm yields big clue on muscle receptor action

Researchers at the University of Illinois at Chicago have identified an elusive subunit of a neurotransmitter receptor found in both humans and the much-studied laboratory nematode C. elegans which may open new pathways of research on muscle function.

The neurotransmitter acetylcholine binds to two different nicotinic receptors at the nematode's neuromuscular junctions, causing them to contract. Previously, researchers knew the subunit composition only of the levamisole-sensitive acetylcholine receptors. In the second, levamisole-insensitive acetylcholine receptors, a subunit called acetylcholine receptor 16, or ACR-16, has now been identified as necessary for this receptor's contribution to muscle contraction.

Janet Richmond, assistant professor of biological sciences at UIC, along with graduate students Denis Touroutine and Anna Burdina, reported the findings in the July 22 issue of the Journal of Biological Chemistry. The research also drew on bioinformatic data provided by David Miller, associate professor of cell and developmental biology at Vanderbilt University, and work by his graduate students Rebecca Fox and Stephen Von Stetina.

Richmond has developed a preparation for cutting open the microscopic nematode to record muscle responses when acetylcholine is applied. Using this preparation, Richmond was still getting muscle contraction when acetylcholine was applied to worms lacking any of five receptor subunits known to be sensitive to levamisole, a chemical that poisons nematodes. Two additional receptor subunits -- ACR-16 and ACR-8 -- identified using Vanderbilt's data, were found to be likely candidates for the remaining acetylcholine response. ACR-16 was singled out as the key subunit.

"We've shown the ACR-16-containing receptor is present in muscle and contributes hugely to the synaptic current," said Richmond.

"Now we can tag this receptor, see if it's localized at the synapse and start to mutagenize animals to fig ure out what makes that receptor stay or make it to the synapse," she added.

Richmond said the finding might have direct relevance to humans because the ACR-16 receptor is very similar to the alpha-7 nicotinic receptor in the human brain.


'"/>

Source:University of Illinois at Chicago


Related biology news :

1. Small species back-up giant marsupial climate change extinction claim
2. Small molecule inhibitor of cholera discovered
3. Small molecule interactions were central to the origin of life
4. Small, smaller, smallest -- The plight of the vaquita
5. Small molecule dervived from Rb2/p130 could act as cancer therapeutic
6. Smallpox outbreak: How long would it take for vaccines to protect people? Would it work?
7. Genome-wide mouse study yields link to human leukemia
8. Marine sponge yields nanoscale secrets
9. Organic farms produce same yields as conventional farms
10. GM crop that holds on to its seeds offers higher yields
11. Seaweed yields new compounds with pharmaceutical potential
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2016)... , March 23, 2016 ... Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung mit ... Inc. (NASDAQ: MESG ), ein ... dass das Unternehmen mit SpeechPro zusammenarbeitet, um ... der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im ...
(Date:3/17/2016)... , March 17, 2016 ABI ... intelligence, forecasts the global biometrics market will reach ... impressive 118% increase from 2015. Consumer electronics, particularly ... embedded fingerprint sensors anticipated to reach two billion ... Dimitrios Pavlakis , Research Analyst at ...
(Date:3/11/2016)... Germany , March 11, 2016 http://www.apimages.com ... - Cross reference: Picture is available at AP Images ( http://www.apimages.com ... from DERMALOG will be used to produce the new refugee identity ... other biometric innovations, at CeBIT in Hanover ... scanner from DERMALOG will be used to produce the new refugee ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... CA (PRWEB) , ... May 23, 2016 , ... ... public interest organization focused on molecular nanotechnology, announced the winners for the 2015 ... pioneer physicist Richard Feynman, are given in two categories, one for experiment and ...
(Date:5/20/2016)... ... ... The recent recall by Costco and Trader Joes of 47 million pounds of ... demonstrates the need for faster and more cost effective bio-threat detection to ensure food ... , PathSensor’s latest solution uses a biosensor technology called CANARY®. CANARY®, an ...
(Date:5/19/2016)... , May 19, 2016 ... and (OTC PINK: RGBPP) announced today initiation of ... first cord blood based cancer immunotherapeutic product leveraging ... application, Regen described a generation of cord blood ... by gene silencing.  The product in development will ...
(Date:5/18/2016)... ... 18, 2016 , ... STACS DNA Inc., the sample tracking software company, today ... assault kit processing to help them save time and reduce errors. , Sexual Assault ... be processed and victims informed of results. Due to a previous lack of tools, ...
Breaking Biology Technology: