Navigation Links
Slowing the racing heart

Researchers at the University of Illinois at Chicago explain in the May 11 issue of Circulation Research how an enzyme acts on the heart's pacemaker to slow the rapid beating of the heart's "fight-or-flight" reaction to adrenaline.

A single cell in the upper right chamber is responsible for setting the pace of the beating heart, triggering its neighbor cells to beat. In the human heart, one cell -- the pacemaker cell -- beats faster or slower to induce a rhythmic heartbeat that varies to increase or decrease the blood flow to the body as we eat, sleep or exercise.

"Disturbances of pacemaker control are common in heart diseases. When the heartbeat becomes non-rhythmic and chaotic, it can result in fatal arrhythmias and stroke," said R. John Solaro, UIC distinguished university professor and principal investigator of the study.

Current treatment of arrhythmia requires destruction of tissue surrounding a chaotic pacemaker, followed by insertion of a mechanical pacemaker that can regulate the heartbeat.

"Understanding the molecular regulation of the heart's pacemaker opens the possibility of less drastic treatment options, including drug interventions," said Solaro, who is also director of the center for cardiovascular research and head of physiology and biophysics at UIC.

Solaro worked with Yunbo Ke, UIC research assistant professor of physiology and biophysics and first author of the paper, and colleagues in England at Oxford and Manchester on characterizing and isolating the pacemaker cell.

The UIC researchers demonstrated that an enzyme called Pak 1, present in high concentrations in the heart, signals depression in the action of adrenaline and adrenaline-like chemicals on the pacemaker cell, playing an important role in slowing down the heart rate.

"The enzyme works through calcium and potassium channels that we know to be key players in the generation and regulation of the pacemaker activity,"
'"/>

Source:University of Illinois at Chicago


Page: 1 2

Related biology news :

1. Getting old? Slowing down? Blame inefficient mitochondria
2. Tracing the formation of long-term memory
3. Tracing broken wiring in stroke patients
4. Single stem cells from bone heal a broken heart
5. Global study shows all tobacco bad for the heart
6. New study shows antibiotic may protect the heart
7. Getting to the heart of the heart
8. How fish mend a broken heart
9. Hawaiian treasure, macadamia nuts good for the heart
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Slowing the racing heart

(Date:7/24/2014)... For years, researchers and patients have hoped that ... type in the bodycould provide insight into numerous diseases ... has been hampered by the inability to transfer research ... counterparts, in part because human ESCs are "primed" and ... Thorold Theunissen, Benjamin Powell, and Haoyi Wang, who are ...
(Date:7/24/2014)... conducting research into the potato genes that best adapt ... reduction in rainfall and increased extremes of hot and ... genes in order to create new potato varieties that ... also seeking to find out how the current potato ... and higher and lower temperatures. , This research is ...
(Date:7/24/2014)... of researchers led by the University of York has ... in the Western Indian Ocean. , The results, ... to a revolution in the management of marine protected ... than 11,000 km in the region now under ... zones of the seas and coasts designed to protect ...
Breaking Biology News(10 mins):Whitehead Institute researchers create 'naïve' pluripotent human embryonic stem cells 2Neiker-Tecnalia is researching the potato genes that best adapt to climate change 2Western Indian Ocean communities play vital role in conservation 2
... The last decade has seen a dramatic decline ... public health crisis across the world. A new ... patients a potential new approach toward the creation of ... become more resistant to our current classes of antibiotics, ...
... CLEVELAND Sediment in rivers comes from erosion of the ... banks themselves. Just how much each source contributes to a ... of that river is the subject of research by ... University. Taking measure of certain radionuclides found in the ...
... - When a reactor in the Chernobyl nuclear power ... Soviet republic of Ukraine, radioactive elements were released in ... and even eastern portions of North America. , ... Reserve University traveled to Sweden and Poland to gain ...
Cached Biology News:Groundbreaking discovery may lead to stronger antibiotics 2Case Western Reserve University project ties soil conservation and river management together 2Case Western Reserve University researchers track Chernobyl fallout 2
(Date:7/24/2014)... 2014   Cypher Genomics, Inc., the ... Adam Simpson as president and chief ... comprehensive annotation and interpretation of individual human genomes ... "Cypher,s technology has the potential to play a ... accuracy, optimizing therapeutic approaches and reducing adverse drug ...
(Date:7/24/2014)... The patent provides substantially greater ... results. It also enables true sample ID and ... reporting of high profile assays such as those ... growing area of biotechnology that includes DNA based ... companion diagnostics in personalized medicine. The new patent ...
(Date:7/23/2014)... Ras Al Khaimah, United Arab Emirates (UAE) (PRWEB) July ... equity firm Grace Century recently announced that ... Dr. Jim Vaught , Ph.D. to its growing ... Century said, “We are very pleased to have Dr. ... along with the scientific depth and expertise that Provia’s ...
(Date:7/23/2014)... efforts have made great strides in saving China,s endangered ... are over 65 giant panda reserves that have been ... efforts, just 1596 pandas remain in the wild. ... to save the panda by improving genetic diversity, avoid ... Just how are these high-profile programs doing so far? ...
Breaking Biology Technology:Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3New DNA-barcode Patent Virtually Eliminates False Test Results and Sample Mix-up 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 3Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 4
... for some time that the hormone leptin acts in the ... remained a mystery. Now, new research published by Cell Press ... reveals neurobiological mechanisms that may underlie the antiobesity effects ... by fat cells and acts at its receptor in the ...
... clot-forming platelets every day, but there are times when ... diseases or during invasive surgery. Now, University of Pennsylvania ... bone marrow cells called megakaryocytes to quadruple the number ... student of pharmacology in Penn,s Perelman School of Medicine, ...
... carbon nanotubes, developed by MIT researchers, shows promise as an ... needed. Storing the sun,s heat in chemical form ... itself in a heavily insulated container has significant advantages, ... long periods of time without losing any of its stored ...
Cached Biology Technology:Modulation of inhibitory output is key function of antiobesity hormone 2Penn researchers show single drug and soft environment can increase platelet production 2Penn researchers show single drug and soft environment can increase platelet production 3MIT research update: New way to store sun's heat 2MIT research update: New way to store sun's heat 3
... The Varian 500-MS LC Ion ... for high-throughput LC/MS analysis where sensitivity, ... Varian 500-MS provides a robust platform ... sensitivity, mass resolution, and mass stability ...
... ejector is a unique product that facilitates ... their holder. Linkage: This CLS number is ... match Cornings product number. If showing no ... Sigma-Aldrich number (Z71,314-7) or contact customer service ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
... These versatile enclosures ... with nitrogen or other ... a low-humidity environment. HEPA ... and ionization modules also ...
Biology Products: