Navigation Links
Slowing the racing heart

Researchers at the University of Illinois at Chicago explain in the May 11 issue of Circulation Research how an enzyme acts on the heart's pacemaker to slow the rapid beating of the heart's "fight-or-flight" reaction to adrenaline.

A single cell in the upper right chamber is responsible for setting the pace of the beating heart, triggering its neighbor cells to beat. In the human heart, one cell -- the pacemaker cell -- beats faster or slower to induce a rhythmic heartbeat that varies to increase or decrease the blood flow to the body as we eat, sleep or exercise.

"Disturbances of pacemaker control are common in heart diseases. When the heartbeat becomes non-rhythmic and chaotic, it can result in fatal arrhythmias and stroke," said R. John Solaro, UIC distinguished university professor and principal investigator of the study.

Current treatment of arrhythmia requires destruction of tissue surrounding a chaotic pacemaker, followed by insertion of a mechanical pacemaker that can regulate the heartbeat.

"Understanding the molecular regulation of the heart's pacemaker opens the possibility of less drastic treatment options, including drug interventions," said Solaro, who is also director of the center for cardiovascular research and head of physiology and biophysics at UIC.

Solaro worked with Yunbo Ke, UIC research assistant professor of physiology and biophysics and first author of the paper, and colleagues in England at Oxford and Manchester on characterizing and isolating the pacemaker cell.

The UIC researchers demonstrated that an enzyme called Pak 1, present in high concentrations in the heart, signals depression in the action of adrenaline and adrenaline-like chemicals on the pacemaker cell, playing an important role in slowing down the heart rate.

"The enzyme works through calcium and potassium channels that we know to be key players in the generation and regulation of the pacemaker activity,"
'"/>

Source:University of Illinois at Chicago


Page: 1 2

Related biology news :

1. Getting old? Slowing down? Blame inefficient mitochondria
2. Tracing the formation of long-term memory
3. Tracing broken wiring in stroke patients
4. Single stem cells from bone heal a broken heart
5. Global study shows all tobacco bad for the heart
6. New study shows antibiotic may protect the heart
7. Getting to the heart of the heart
8. How fish mend a broken heart
9. Hawaiian treasure, macadamia nuts good for the heart
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Slowing the racing heart

(Date:12/19/2014)...   LaunchKey , the first decentralized mobile authentication ... of Things era, today announced the close of $3 ... led by Metamorphic Ventures with participation from ENIAC Ventures, ... others.  LaunchKey has raised $4 million to date, and ... and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
(Date:12/17/2014)...  Automation is fundamentally transforming the travel experience ... international borders. Over the past decade, ePassports, biometric ... travelers to self process through border control via ... an increasing number of airports, seaports, and land ... to Maxine Most , Principal at Acuity ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... swamps, sawgrass prairies and subtropical jungles, could the Florida ... oil spill? While current estimates are that little ... the Everglades, this area is a significant national natural ... on seagrasses and mangrove forests in and near the ...
... Service Southern Research Station (SRS) Director Jim Reaves today ... nonnative invasive plants in the South can now request ... of Invasive Plants in Southern Forests." The long-awaited book ... Plants of Southern Forests: A Field Guide for Identification ...
... , Opportunities for in-depth interviews and discussions with ... in Europe and beyond You will hear different aspects ... in Europe, Use of ART data from Europe and ... limitations of pooling ART infant outcome data from different ...
Cached Biology News:Gulf oil spill: NSF funds research on impacts to Florida Everglades 2Forest Service updates free guide to 'Invasive Plants in Southern Forests' 2The European IVF Monitoring Group celebrates its 10-year anniversary 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... on Company,s Website -, TUSTIN, Calif., Feb. 7 ... stage biopharmaceutical,company developing monoclonal antibodies for the treatment of ... management will,present at the 10th Annual BIO CEO & ... EST. The conference will be held at the,Waldorf-Astoria Hotel ...
... MAUI, Hawaii, Feb. 7 Bioponic Phytoceuticals,Inc. ("Bioponic" or ... month of January 2008 increased 40% compared to sales ... record breaking month of sales in January, primarily,from continued ... gaining,market traction for our latest product release, an all-natural ...
... China Shenghuo,Pharmaceutical Holdings, Inc. ("China Shenghuo," "the ... research, development, manufacture, and,marketing of pharmaceutical, nutritional ... of China ("PRC"), today announced it will ... the United States during the,first quarter of ...
Cached Biology Technology:Peregrine Pharmaceuticals to Present at the 10th Annual BIO CEO & Investor Conference 2Bioponic Phytoceuticals Announces Record Sales Increase of 40% for the Month of January 2China Shenghuo to Market 12Ways(R) Skin Care Products in the U.S. through Agreement with Home Shopping Group 2China Shenghuo to Market 12Ways(R) Skin Care Products in the U.S. through Agreement with Home Shopping Group 3
ABCA1 Immunogen: Mouse ABCA1-expressing HeLa stable transfectants. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Anti-rat Dipeptidyl Peptidase IV (DPP IV), CD26, Clone 5E8, Monoclonal Antibody...
JAB1 Immunogen: Synthetic peptide, conjugated to KLH, corresponding to residues S(201) E Y Q T I P L N K I E D F G V(216) of human JAB1. The sequence is identical in mouse and rat. Storage: -...
... used to detect the appearance of AcNPV ... cells as early as 8-24 hours post-infection. ... Titer Kit, which allows determination of baculovirus ... The FastPlax Antibody can also be used ...
Biology Products: