Navigation Links
Sleepless for science: Flies show link between sleep, immune system in Stanford study

step, after confirming that flies lost sleep when infected, was to ask the converse: when sleep is disrupted, does that affect immunity"

The challenge was how to disrupt the flies' sleep. Schneider tried building a machine that jostled the flies randomly. "All it was really good at doing was throwing the tubes around the room," said Schneider. "Also it was too regular, the flies got used to it so they could nap."

Another option was to keep the flies in continuous light. But Schneider and Shirasu-Hiza decided that an even better way would be to turn to established fly strains isolated decades ago that possess disruptions in their genes controlling circadian rhythm. In this case, these mutant flies could be kept under exactly the same light and temperature conditions as the normal flies.

They looked at flies that were defective in one of two genes, called "timeless" and "period". They found that the loss of either gene's function made the flies more sensitive to bacterial infections and these sick flies died significantly faster than control flies, which lived two to four times as long as the sick ones.

"We want to know how the internal clock knows the animal is infected, and how does the immune system know that you are not sleeping properly"" said Schneider. "How do those messages get sent back and forth""

Their findings also raise the question of why the flies have a change in their sleep pattern when infected. The researchers speculate that from an evolutionary standpoint, there may be some microbes that are fought better when sleep is disrupted, although clearly not the two microbes they tested in the current study. "We think that is the reason flies do this," said Schneider, "but sometimes it's a good thing, sometimes it's a bad thing."

Building on their findings, they can begin to answer these questions. Shirasu-Hiza will be testing mutant flies with other circadian rhythm genes missing.

They
'"/>

Source:Stanford University Medical Center


Page: 1 2 3

Related biology news :

1. Flies on speed offer insight into the roles of dopamine in sleep and arousal
2. Flies dont buzz about aimlessly!
3. Variation in womens X chromosomes may explain differences among individuals, between sexes
4. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
5. Study reveals dramatic difference between breast cancers in US and Africa
6. Molecular fossils uncover link between viruses and the immune system
7. Research may provide new link between soft drinks and weight gain
8. A new molecule discovered in the battle between plants and disease
9. Underground tunnels discovered as means for communication between immune system cells
10. New discovery blurs distinction between human cells and those of bacteria
11. Plants discriminate between self and non self
Post Your Comments:
(Date:7/10/2014)... BLUE BELL, Pa. , July 2, 2014  Unisys ... The Netherlands , Unisys Nederland N.V., today announced that ... (DJI) to deliver, implement and manage a new Basic Provision ... . Unisys won the contract with a ... for identity management software. The term of the contract is ...
(Date:7/10/2014)... DALLAS , July 3, 2014 ... Sensors Market by Type (Swipe And Area), Material (Optical ... Defense, Healthcare, Commercial Security and Banking & Finance), and ... 2020", published by MarketsandMarkets, the global Fingerprint Sensors Market ... at a high CAGR of 16.8% from 2014 to ...
(Date:7/10/2014)... 2014 According to a new ... Control Systems Market Global Forecast, Market Share, Size, Growth ... Access Control systems market was valued at USD 15,406.1 ... a CAGR of 12.6% from 2014 to 2019, to ... 2019. Browse the full Electronic Access Control ...
Breaking Biology News(10 mins):Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5
... , BETHESDA, Md., June 24, 2010 The National ... five-year grant to the American Society for Biochemistry and ... for educators across the nation. The initiative aims ... by establishing foundational concepts and skills for the discipline ...
... grow with less fertilizer, herbicide, fuel, and erosion than ... according to researchers writing in the current issue of ... be one of the largest innovations in the 10,000 ... with the right breeding programs, said John Reganold, Washington ...
... University biomedical engineers and researchers from the University of ... device that is powerful enough to let doctors easily ... the LCD monitor on the back of the camera. ... camera were published online this week in the open-access ...
Cached Biology News:NSF grant will develop new online hub for biochemistry, molecular biology educators 2Agriculture's next revolution -- perennial grain -- within sight 2Off-the-shelf cancer detection 2
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., the ... relaunch of his highly informative blog, now named Stem Cells ... are Stem Cells ?” Dr. Harman’s purpose for blogging ... basics of stem cell therapy so that pet owners can ... when considering regenerative medicine. , A veterinarian by trade, Dr. ...
(Date:7/10/2014)... QC (PRWEB) July 10, 2014 EvoDerma ... and convenience. This rejuvenating device now comes with a second ... develops over time. , The new cup is thinner on ... design works to target rough, thin and uneven surfaces on ... firm cup for a stimulating treatment on areas such as ...
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
(Date:7/10/2014)... July 10, 2014  Kainos Capital, a firm specializing ... announced that it has acquired the Slim-Fast brand from ... business. Terms of the transaction were not disclosed. ... replacement business that markets ready-to-drink shakes, powders, bars and ... and in the United Kingdom ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Kainos Capital Acquires Slim-Fast From Unilever 2
... Oct. 3 Thermo Fisher,Scientific Inc. (NYSE: ... has acquired Priority,Solutions International, a leading third-party ... following anti-trust clearance.,Priority Solutions was previously majority-owned ... $95 million in 2006, Priority,Solutions offers a ...
... equity stake in Zenotech Laboratories to 45%, GURGAON, ... Laboratories Limited (Zenotech) today announced the,signing of Definitive Agreements, ... its current 7% to 45% at a price of ... involves: (a) Purchase of shares from the existing ...
... With a special eye for the,details hidden from ... Mara G. Aspinall. Photographs of architectural details from beaches,to ... the fore. The,collection includes images from seven different countries., ... Aspinall, the,president of Genzyme Genetics, is also a talented ...
Cached Biology Technology:Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 2Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 3Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 4Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 3An Uncommon Eye: Photography Exhibit by Biotechnology Executive at BHCC Gallery 2
... phase reagent for Virus ... & unique water insoluble ... detergents and chaotropes; Engineered ... non-envelop viruses while preserving ...
Tumor Suppressor Sampler Kit 10 mu g each...
Monoclonal Antibody toSynapsin I a and I b Neurofilament associated protein from mouse brain extracts (4)....
Slide Chambers are convenient for performing pre-hybridization incubations and post-hybridization washes with tissue sections mounted on standard glass microscope slides. Each chamber holds up to 5 s...
Biology Products: