Navigation Links
Sleeping sickness parasite shows how cells divide their insides

Researchers at Yale have brought to light a mechanism that regulates the way an internal organelle, the Golgi apparatus, duplicates as cells prepare to divide, according to a report in Science Express.

Graham Warren, professor of cell biology, and his colleagues at Yale study Trypanosoma brucei, the parasite that causes Sleeping Sickness. Like many parasites, it is exceptionally streamlined and has only one of each internal organelle, making it ideal for studying processes of more complex organisms that have many copies in each cell.

When thinking about how cells divide, doubling and separating DNA in chromosomes is often the focus. Equally important is the way a cell prepares its internal organelles for distribution. Warren studies the Golgi complex, a membrane compartment in the cytoplasm that delivers newly-made proteins to different membranes in the cell.

"Basal bodies in particular and centrosomes in general have been implicated in the biogenesis of a number of membrane-bound organelles," said Warren. "It prompted us to study further their role in Golgi duplication."

Warren's group has identified a new cellular structure, distinct from the basal body, involved in the duplication of the Golgi apparatus and defined by a highly-conserved protein, Centrin2. This structure has two lobes -- one at the old Golgi, the other where the new Golgi forms. Once a new Golgi has grown, the Centrin structure itself duplicates so that two complete structures, and associated Golgi, are ready to be allocated to daughter cells.

Significant recent advances in the molecular genetics of trypanosomes by Elisabetta Ullu and Christian Tschudi's group at Yale, allowed direct man ipulation of protein levels using the innate RNA interference (RNAi) system.The relationship between the growing Golgi, the Centrin proteins and other cellular organelles was shown in experiments using RNAi, and visualizing the process was possible with fluorescent protein tags. How this process relates to higher organisms is the focus of present research.


'"/>

Source:Yale University


Related biology news :

1. Sleeping Sickness Epidemic Spreading in Uganda
2. Sleeping beauty plays a significant role in identifying cancer genes
3. Newly discovered protein an important tool for sleeping sickness research
4. Compound might defeat African sleeping sickness, clinical trial beginning this month
5. A large step forward in the fight against African sleeping sickness
6. Resistance and genetic sensitivity to sleeping sickness
7. New study suggests promising drug combinations for sleeping sickness
8. Scientists reveal molecular secrets of the malaria parasite
9. Protein offers way to stop microscopic parasites in their tracks
10. A human parasite with a streamlined mitochondrion
11. Invasive parasite destroying fish species
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/25/2016)... Jan. 25, 2016  Glencoe Software, the world-leading supplier ... publication industries, will provide the data management solution OMERO ... Photo ... Phenotypic analysis measures the characteristics ... allowing comparisons between states such as health and disease, ...
(Date:1/20/2016)... , Jan. 20, 2016 A market ... to directly benefit from the explosion in genomics knowledge. ... Howe Sound Research. A range of dynamic trends are ... - personalized medicine - pharmacogenomics - pathogen evolution ... with large markets - greater understanding of the role ...
(Date:1/15/2016)... , Jan. 15, 2016 Recent publicized breaches ... to find new ways to ensure data security and ... iOS and Android that ties a ... transforming it into a hardware authorization token. Customer service ... their fingerprint on their KodeKey enabled device to verify ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... -- NX Prenatal Inc., a US based molecular ... early warning of adverse pregnancy outcomes, announced today ... Dr. Thomas McElrath of Brigham & ... (SMFM) annual meeting held in Atlanta ... presentation reported initial positive top-line results regarding the ...
(Date:2/10/2016)... DUBLIN , Feb. 10, 2016  Allergan plc ... today announced that Brent Saunders , Allergan,s CEO ... in a fireside chat session at the RBC Capital ... 12:30 p.m. ET at The New York Palace Hotel ... presentation will be webcast live and can be accessed ...
(Date:2/10/2016)... Latham, NY (PRWEB) , ... February 10, 2016 , ... ... photodiode packages at the SPIE Photonics West conference in San Francisco’s Moscone ... and 14 in the same venue. , These latest InGaAs PIN diode standard ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... medicine, has announced a new agreement with Singapore-based Global Stem Cells Network (GSCN) ... the Philippines, Thailand and Singapore in the latest adipose and bone marrow therapies. ...
Breaking Biology Technology: