Navigation Links
Sleeping beauty plays a significant role in identifying cancer genes

s, and it's hard to know from the correlations which genes relate to cancer and which do not," said Largaespada. "By comparison, the jumping gene has inserted itself into cancer genes in the tumors we studied and thereby allows us to focus on smaller numbers of genes -- genes that we know are important to the genesis of tumors. The result is a quicker, more efficient and accurate identification of cancer-causing genes."

Nancy Jenkins, Ph.D., head of NCI's Molecular Genetics of Development, and Neal Copeland, Ph.D., head of the Molecular Genetics of Oncogenesis in the Mouse Cancer Genetics program, led the NCI research team, which investigated the use of a highly mobile Sleeping Beauty transposon system to study lymphomas, a cancer that strikes the immune system.

"Although our discovery was made in laboratory mice," said Jenkins, "we believe that the technology used will reveal new insights into human cancer and could be translated for clinical use. Hopefully, this discovery will speed up the development of new drugs and improve already-in-use drugs that target specific genes for treatment of various types of cancer, including lymphomas.

The outcome of the new Sleeping Beauty method could be a major leap forward in understanding cancer's weak points and thus lead to better treatments."

According to Largaespada, "About 300 human cancer-related genes have thus far been reported in the scientific literature. Most of those identified are involved in cancers of the blood system. So, there are likely to be many more cancer genes that still need to be identified."

Additionally, he noted that the Sleeping Beauty technology is capable of providing important information about the genes that current methods do not -- such as the specific combinations of mutant genes that can work together to cause cancer. "With this information, we will understand the development of tumors at the genetic level in much finer detail," he said. "This is impo
'"/>

Source:NIH/National Cancer Institute


Page: 1 2 3

Related biology news :

1. Sleeping Sickness Epidemic Spreading in Uganda
2. Sleeping sickness parasite shows how cells divide their insides
3. White blood cell waste disposal system plays critical regulatory role
4. Micro-molecule plays big role in birth defects
5. Neural stem cell gene plays crucial role in eye development
6. Got inexpensive contrast agent? Milk plays new role in imaging
7. Zinc plays important role in brain circuitry
8. Fish species plays surprise role in aiding coral reef recovery
9. Anticipation plays a powerful role in human memory, brain study finds
10. Motor protein plays key role in connecting neurons
11. Confirmed -- deforestation plays critical climate change role
Post Your Comments:
(Date:7/9/2014)... the oils produced by algae may offer a low-cost ... optimization of cost effective strategies for large-scale algae cultivation, ... Energy has developed an innovative solution to the challenge ... in Industrial Biotechnology , a peer-reviewed journal from ... on the Industrial Biotechnology website . ...
(Date:7/9/2014)... Ill. With over 100 diseases that can attack ... top of the most wanted list? University of Illinois ... that more research is needed on the fungus that ... with cool, damp growing conditions but Macrophomina phaseolina ... and dry drought conditions. , "As the climate continues ...
(Date:7/9/2014)... a sparrow-sized fossil from China challenges the commonly held ... gained the ability to fly. The birdlike fossil is ... rather the remains of a tiny tree-climbing animal that ... Dinosaur Museum in Blanding, Utah, and Alan Feduccia of ... Springer,s Journal of Ornithology . , The fossil ...
Breaking Biology News(10 mins):Controlling contamination in open algae ponds for biofuels 2Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3Researchers declassify dinosaurs as being the great-great-grandparents of birds 2
... An international research team led by Nanjing Agricultural ... of pear by an approach using the combination of ... only provides an invaluable new resource for breeding improvement ... on the genome evolution and other genome-wide comparative studies. ...
... 19, 2012 Medbox, Inc. (Ticker: MDBX) ( www.medboxinc.com ... they have received many inquiries from shareholders purchasing shares ... week,s volatile trading. These inquiries were responded to and ... rapport. In other news, the company ...
... person imagines moving a limb, cells in the part ... if trying to make the immobile limb work again. ... pathway between brain and muscle, the region where the ... recent years, neuroscientists and neuroengineers working in prosthetics have ...
Cached Biology News:Pear genome provides new insight into breeding improvement and evolutionary trace analysis 2Medbox Communicates with Shareholders, Comments on Pending Transition to OTC Bulletin Board, and Announces Appearance on Fox Business News Channel 2A better thought-controlled computer cursor 2A better thought-controlled computer cursor 3A better thought-controlled computer cursor 4A better thought-controlled computer cursor 5
(Date:1/15/2014)... This webinar will focus on EMA ... assessment in biosimilars. , Regulatory frameworks are evolving many ... however the complex nature of biopharmaceuticals makes the demonstration ... extremely challenging. Based on the specific aspects of biosimilar ...
(Date:1/15/2014)... January 15, 2014 DTS Language Services, ... Online Web Portal for Life Science organizations who need document ... the subject matter of their documents in advance with a ... reduce time-to-delivery of translations, often a critical factor in clinical ...
(Date:1/14/2014)... 2014 Date: Friday, April 11, 2014 , ... Club, 1360 Almshouse Road, Warrington, Pa. , Details: ... dedicated to finding a cure for hepatitis B and improving ... its annual Crystal Ball on Friday, April 11 at Warrington ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging ... to serve the wound care market. , Free report ... was restructured with a seasoned management team and Board, ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... LA JOLLA, Calif., Feb. 23, 2011 ... to providing personalized treatment information to women with ... been appointed Executive Director, a new position for ... to lead the foundation as it increases its ...
... CITY, Calif., Feb. 23, 2011 Ingenuity® Systems, ... for life science researchers, today announced a research ... for next-generation sequencing (NGS) data analysis. Covance Genomics ... the drug discovery and development industry, and Ingenuity ...
... in German . , Further development of ... at reasonable costs. In the past, integration density of ... of this strategy, future components will have to reach ... Center for Functional Nanostructures (CFN) and IPCMS have now ...
Cached Biology Technology:The Clearity Foundation Hires Hillary Theakston as Executive Director 2The Clearity Foundation Hires Hillary Theakston as Executive Director 3Ingenuity Systems and Covance Collaborate to Support Next-Generation Sequencing Research 2Smallest magnetic field sensor in the world 2
... of SYBR Green I or FAM in ... fluorophores in the second channel including ... a multitude of applications such as RT-qPCR ... offers precision thermal control and a temperature ...
... identification and library manager ... that adds capabilities for ... identification of unknowns against ... of the same taxon ...
Fingerprinting II comparative quantification and polymorphism analysis is an optional module that adds comparative quantification and polymorphism analysis functions to the Fingerprinting II Basic so...
... or for use in an automated line. ... disposable manifold provides greater ease, speed, convenience, ... StatMatic II can be connected to a ... fill a microplate with one-handed operation -- ...
Biology Products: