Navigation Links
Single stem cells from bone heal a broken heart

Myocardial infarction results in irreversible damage to the heart that can cause congestive heart failure. The lasting damage results from the limited ability of the myocardium to regenerate and self-repair. Douglas Losordo and colleagues from Tufts University now document the existence of a previously unrecognized subset of human bone marrow–derived stem cells with therapeutic potency for myocardial tissue regeneration following myocardial infarction.

In their study, featured in the February 1 issue of the Journal of Clinical Investigation the authors isolated these human cells at the single cell level and were able to differentiate them into all different cell types. When single human bone marrow–derived stem cells were allowed to divide to form a large population, they were transplanted into a rat model of myocardial infarction. This improved cardiac function because the cells stimulated release of growth factors and anti-apoptotic agents that, in turn, increased the proliferative potential of cardiomyocytes and enhanced survival of host myocardium. This is the first report of endogenous cardiomyogenesis after adult human stem cell transplantation.

Myocardial infarction and heart failure are associated with major morbidity and mortality and there are currently limited therapeutic opportunities for intervention. This study provides the first demonstration of a single, human stem cell population derived from the bone marrow that has the capacity to induce generation of new heart cells and formation of new blood vessels ?two key components of successful myocardial repair. The results provide a foundation on which new approaches to repair the damaged heart can be based.

Related : Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction, JCI


'"/>

Source:JCI


Page: 1

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
3. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
4. Single gene is genetic switch for fly sexual behavior
5. Single microRNA causes cancer in transgenic mouse
6. Single cell amoeba increases MRSA numbers 1000- fold
7. Single molecular mark seen as pivotal for genome compaction in spores and sperm
8. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
9. Wisconsin scientists grow critical nerve cells
10. Spleen may be source of versatile stem cells
11. Researchers discover way to make cells in the eye sensitive to light
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... WASHINGTON , June 22, 2016 On ... highly-anticipated call to industry to share solutions for the ... by U.S. Customs and Border Protection (CBP), explains that ... nationals are departing the United States ... criminals, and to defeat imposters. Logo - ...
(Date:6/15/2016)... June 15, 2016 Transparency ... titled "Gesture Recognition Market by Application Market - Global Industry Analysis ... 2024". According to the report, the  global gesture recognition ... 2015 and is estimated to grow at a ... by 2024.  Increasing application of gesture ...
(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, ... faculty of the University of North Carolina Kenan-Flagler Business School effective ... at UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes ...
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/23/2016)... ... 2016 , ... UAS LifeSciences, one of the leading manufacturers ... Probiotics, into Target stores nationwide. The company, which has been manufacturing high quality ... list of well-respected retailers. This list includes such fine stores as Whole Foods, ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
Breaking Biology Technology: