Navigation Links
Single stem cells from bone heal a broken heart

Myocardial infarction results in irreversible damage to the heart that can cause congestive heart failure. The lasting damage results from the limited ability of the myocardium to regenerate and self-repair. Douglas Losordo and colleagues from Tufts University now document the existence of a previously unrecognized subset of human bone marrow–derived stem cells with therapeutic potency for myocardial tissue regeneration following myocardial infarction.

In their study, featured in the February 1 issue of the Journal of Clinical Investigation the authors isolated these human cells at the single cell level and were able to differentiate them into all different cell types. When single human bone marrow–derived stem cells were allowed to divide to form a large population, they were transplanted into a rat model of myocardial infarction. This improved cardiac function because the cells stimulated release of growth factors and anti-apoptotic agents that, in turn, increased the proliferative potential of cardiomyocytes and enhanced survival of host myocardium. This is the first report of endogenous cardiomyogenesis after adult human stem cell transplantation.

Myocardial infarction and heart failure are associated with major morbidity and mortality and there are currently limited therapeutic opportunities for intervention. This study provides the first demonstration of a single, human stem cell population derived from the bone marrow that has the capacity to induce generation of new heart cells and formation of new blood vessels ?two key components of successful myocardial repair. The results provide a foundation on which new approaches to repair the damaged heart can be based.

Related : Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction, JCI


'"/>

Source:JCI


Page: 1

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
3. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
4. Single gene is genetic switch for fly sexual behavior
5. Single microRNA causes cancer in transgenic mouse
6. Single cell amoeba increases MRSA numbers 1000- fold
7. Single molecular mark seen as pivotal for genome compaction in spores and sperm
8. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
9. Wisconsin scientists grow critical nerve cells
10. Spleen may be source of versatile stem cells
11. Researchers discover way to make cells in the eye sensitive to light
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/22/2016)... PUNE, India , March 22, 2016 ... new market research report "Electronic Sensors Market for ... Fingerprint, Proximity, & Others), Application (Communication & ... and Geography - Global Forecast to 2022", ... consumer industry is expected to reach USD ...
Breaking Biology News(10 mins):
(Date:6/22/2016)... , June 22, 2016   StockNewsNow.com , The ... Interview with Dr. Nader Pourhassan , President & ... focused on the clinical development and potential commercialization of ... HIV infection, according to the company,s website (see here: ... Tuesday, June 7 th , 2016, at the LD ...
(Date:6/22/2016)... , June 22, 2016   ViaCyte, Inc. ... pluripotent stem cell-derived islet replacement therapy for the treatment ... at ISSCR 2016 Annual Meeting.  ISSCR 2016, the Global ... 25th at Moscone West in San Francisco.  ... the presentations are as follows:Event: , Focus Session: Tools ...
(Date:6/22/2016)... ... 2016 , ... The Immigrant Journey Awards , an ... North Texas and the nation, recently held its annual luncheon program. Awards ... and economic vitality of North Texas. Proceeds from the event are used to ...
(Date:6/22/2016)... and ALBANY, N.Y. , ... (Teewinot) and Albany Molecular Research, Inc. (NASDAQ: ... licensed Teewinot,s technology to produce and sell the ... The CBCA analytical standard is manufactured using Teewinot,s ... expression of cannabinoid biosynthetic genes in microorganisms for ...
Breaking Biology Technology: