Navigation Links
Single stem cells from bone heal a broken heart

Myocardial infarction results in irreversible damage to the heart that can cause congestive heart failure. The lasting damage results from the limited ability of the myocardium to regenerate and self-repair. Douglas Losordo and colleagues from Tufts University now document the existence of a previously unrecognized subset of human bone marrow–derived stem cells with therapeutic potency for myocardial tissue regeneration following myocardial infarction.

In their study, featured in the February 1 issue of the Journal of Clinical Investigation the authors isolated these human cells at the single cell level and were able to differentiate them into all different cell types. When single human bone marrow–derived stem cells were allowed to divide to form a large population, they were transplanted into a rat model of myocardial infarction. This improved cardiac function because the cells stimulated release of growth factors and anti-apoptotic agents that, in turn, increased the proliferative potential of cardiomyocytes and enhanced survival of host myocardium. This is the first report of endogenous cardiomyogenesis after adult human stem cell transplantation.

Myocardial infarction and heart failure are associated with major morbidity and mortality and there are currently limited therapeutic opportunities for intervention. This study provides the first demonstration of a single, human stem cell population derived from the bone marrow that has the capacity to induce generation of new heart cells and formation of new blood vessels ?two key components of successful myocardial repair. The results provide a foundation on which new approaches to repair the damaged heart can be based.

Related : Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction, JCI


'"/>

Source:JCI


Page: 1

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
3. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
4. Single gene is genetic switch for fly sexual behavior
5. Single microRNA causes cancer in transgenic mouse
6. Single cell amoeba increases MRSA numbers 1000- fold
7. Single molecular mark seen as pivotal for genome compaction in spores and sperm
8. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
9. Wisconsin scientists grow critical nerve cells
10. Spleen may be source of versatile stem cells
11. Researchers discover way to make cells in the eye sensitive to light
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2016)... , May 16, 2016   EyeLock LLC ... today announced the opening of an IoT Center of ... strengthen and expand the development of embedded iris biometric ... unprecedented level of convenience and security with unmatched biometric ... one,s identity aside from DNA. EyeLock,s platform uses video ...
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/26/2016)... and LONDON , ... Finacle, part of EdgeVerve Systems, a product subsidiary ... Onegini today announced a partnership to integrate the ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... provide their customers enhanced security to access and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... announced the launch of the Supplyframe Design Lab . Located in Pasadena, ... explore the future of how hardware projects are designed, built and brought to ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® ... provides a free webinar on Performing Quality Investigations: Getting to Root ... CT at no charge. , Incomplete investigations are still a major concern to ...
(Date:6/22/2016)... , June 22, 2016 Cell ... will allow them to produce up to one ... one lot within one week. These high-quality, consistent ... laboriously preparing cells and spend more time doing ... through a proprietary, high-volume manufacturing process that produces ...
Breaking Biology Technology: