Navigation Links
Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm

mber of important biological purposes.

"During the time the DNA is single-stranded, as it is in the gametes, it's much more susceptible to breaks and mutations," she says. "Compaction may keep the genome resistant to damage of all kinds. This is critical ?if the single-stranded DNA in gametes breaks, it can fall apart and possibly reassemble itself in devastating translocations."

She notes that normal double-stranded DNA, on the other hand, has the ability to repair breaks in one of its single strands by using the chemical bases in the companion strand as a reference. Bases in DNA pair only in predetermined combinations, so that one strand can serve as a template for the other.

"Compaction might also affect sperm fertility and function in the higher organisms, and thus the propagation of the species," says Thanuja Krishnamoorthy, Ph.D., lead author on the study. "It's vital that we better understand genome compaction during the production of mature sperm."

The molecule in question is a phosphorous molecule that modifies a histone. Histones are relatively small proteins around which DNA is coiled to create structures called nucleosomes. Compact strings of nucleosomes, then, form into chromatin, the substructure of chromosomes.

To test the team's observations, Krishnamoorthy performed an experiment in yeast in which she altered the histone's chemical composition at a single point, the point at which the molecule attaches to, or marks, the histone. The results were clear and compelling: With the alteration, the molecule was unable to attach to the histone, and compaction was severely limited.

"We saw a significant increase in genomic volume in the resulting yeast spores, as though the compaction had been lost," Berger says. "The frequency of successful spore creation was also lowered significantly."


'"/>

Source:The Wistar Institute


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Single stem cells from bone heal a broken heart
3. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
4. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
5. Single gene is genetic switch for fly sexual behavior
6. Single microRNA causes cancer in transgenic mouse
7. Single cell amoeba increases MRSA numbers 1000- fold
8. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
9. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
10. Source of molecular triggers in cutaneous T cell lymphoma identified
11. Plants, animals share molecular growth mechanisms
Post Your Comments:
(Date:4/17/2014)... need to produce hydrogen sulfide in order to properly ... study from the Center for Craniofacial Molecular Biology at ... Professor Songtao Shi, principal investigator on the project, said ... governs the flow of calcium ions. The essential ions ... osteogenesis, or the creation of new bone tissue, and ...
(Date:4/17/2014)... in German . ... money demanded of him, he can expect his premises to ... fear of the consequences is enough to make restaurant owners ... which lay their eggs in other birds, nests. If the ... take their revenge by destroying the entire nest. Consequently, it ...
(Date:4/17/2014)... in France have hit on a novel method ... the correct and most effective treatment possible., Kidney ... western and developing world. If left untreated, apart ... renal failure and other complications. In many patients ... Clearly a more effective pathological approach to diagnosis ...
Breaking Biology News(10 mins):Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3
... robust, efficient method of using hydrogen as a fuel source. ... converted to electricity in a fuel cell and because it is ... a gas, it can only be stored in high pressure or ... of hydrogen, "if you got into a wreck, you,d have a ...
... serve remote areas of the world, doctors, nurses and ... relatively inexpensive. Now researchers at the University of ... light-weight, dual-mode microscope that uses holograms instead of lenses. ... published today in the Optical Society,s (OSA) open-access journal ...
... environmental advocates are excited about the prospect of gaining ... like miscanthus or switchgrass rather than corn. ... but one key factor of agriculture has been overlooked: ... energy through bioenergy crops, dependence on water gets ignored, ...
Cached Biology News:Microscope on the go: Cheap, portable, dual-mode microscope uses holograms, not lenses 2Microscope on the go: Cheap, portable, dual-mode microscope uses holograms, not lenses 3Testing the water for bioenergy crops 2
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that they ... Russian pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ... , Turkey and other members ... antibiotic for the treatment of bacterial infections including those ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up ... many of them wrote: "Take better care of my furry companion." ... designer clothes and top-brand carrying cases to take the little canine ... might also feel compelled to buy some pricey toys at the ...
(Date:1/14/2014)... 2014 In recent years, growing suspicion ... in product development and promotion has led to unprecedented ... fueled by concerns about the insidious impact of commercialization ... spectacular fines to the world’s biggest pharmas for illegal ...
(Date:1/14/2014)... Kerr Corporation, a leading manufacturer of innovative dental products, has ... arch impressions on its dental blog. , Titled ... serves up a list of tips to help dentists best ... David Little as he crafts a porcelain crown using Kerr’s ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ... data demonstrating the effectiveness of Oncothyreon,s PX-866 in ... were presented earlier today by William D. Hardie, ... Center, Cincinnati, Ohio, at the American Thoracic Society ...
... Cumberland Pharmaceuticals announced today the launch of ... Acetadote (acetylcysteine) Injection , the company,s ... http://www.newscom.com/cgi-bin/prnh/20090518/CL18638 )Available at ... hospital pharmacists and physicians, educators and other healthcare ...
... Biologic,Products, Inc. (OTC Bulletin Board: CBPO) ("China Biologic," or ... the People,s,Republic of China ("PRC"), reported strong financial results ... First Quarter 2009 Highlights, -- ... -- Gross profit increased 153.1% to ...
Cached Biology Technology:Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis 2Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis 3Cumberland Pharmaceuticals Provides Hospital In-Service Webcast for Acetadote(R) 2Cumberland Pharmaceuticals Provides Hospital In-Service Webcast for Acetadote(R) 3China Biologic Products Announces Strong First Quarter 2009 Results 2China Biologic Products Announces Strong First Quarter 2009 Results 3China Biologic Products Announces Strong First Quarter 2009 Results 4China Biologic Products Announces Strong First Quarter 2009 Results 5China Biologic Products Announces Strong First Quarter 2009 Results 6China Biologic Products Announces Strong First Quarter 2009 Results 7China Biologic Products Announces Strong First Quarter 2009 Results 8China Biologic Products Announces Strong First Quarter 2009 Results 9China Biologic Products Announces Strong First Quarter 2009 Results 10China Biologic Products Announces Strong First Quarter 2009 Results 11China Biologic Products Announces Strong First Quarter 2009 Results 12China Biologic Products Announces Strong First Quarter 2009 Results 13China Biologic Products Announces Strong First Quarter 2009 Results 14