Navigation Links
Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm

In higher order animals, genetic information is passed from parents to offspring via sperm or eggs, also known as gametes. In some single-celled organisms, such as yeast, the genes can be passed to the next generation in spores. In both reproductive strategies, major physical changes occur in the genetic material after it has been duplicated and then halved on the way to the production of mature gametes or spores. Near the end of the process, the material ?called chromatin, the substructure of chromosomes ?becomes dramatically compacted, reduced in volume to as little as five percent of its original volume.

Researchers at The Wistar Institute, studying the mechanisms that control how the genetic material is managed during gamete production, have now identified a single molecule whose presence is required for genome compaction. Their experiments showed that the molecule "marks" the chromatin just prior to compaction and that its presence is mandatory for successful compaction. Additionally, after first noting the molecule's activity during the production of yeast spores, the scientists saw the same activity during the creation of sperm in fruit flies and mice, suggesting that the mechanisms governing genome compaction are evolutionarily ancient, highly conserved in species whose lineages diverged long ago. A report on the new study appears in the September 15 issue of Genes & Development. A "Perspectives" review in the same issue expands on the significance of the findings.

"This molecular mark is required at a critical time leading up to genome compaction in spores and sperm," says Shelley L. Berger, Ph.D., the Hilary Koprowski Professor at The Wistar Institute and senior author on the study. "Also, there seems to be a similarity in the way the mark is used in organisms as different from each other as yeast and mammals, suggesting that compaction has been important throughout evolution."

Berger speculates that compaction might answer a nu
'"/>

Source:The Wistar Institute


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Single stem cells from bone heal a broken heart
3. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
4. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
5. Single gene is genetic switch for fly sexual behavior
6. Single microRNA causes cancer in transgenic mouse
7. Single cell amoeba increases MRSA numbers 1000- fold
8. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
9. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
10. Source of molecular triggers in cutaneous T cell lymphoma identified
11. Plants, animals share molecular growth mechanisms
Post Your Comments:
(Date:9/18/2014)... of carbon and nitrogen comprise all spheres of ... systems have caused imbalances and perturbations that resulted ... Increased GHGs result in climate changes which influence ... and the atmosphere. Understanding these feedback mechanisms has ... environmental science during the past three decades. , ...
(Date:9/18/2014)... has found clownfish larvae can swim up to 400 kilometres ... to cope with environmental change. , Clownfish spend their entire ... as babies they must wander the open ocean, says study ... for Coral Reef Studies (Coral CoE) at James Cook University. ... but now we,ve been given a rare glimpse into how ...
(Date:9/17/2014)... student have designed a device based on a shorebird,s ... dew., The device could provide water in drought-stricken areas ... Luo, professor in the Mechanical & Aerospace Engineering Department, ... of Engineering department, published "Bioinspired Plate-Based Fog Collectors" in ... Applied Materials & Interfaces journal. ...
Breaking Biology News(10 mins):Greenhouse gas research enters a new era 2Nemo's epic journey to find a new home 2Shorebird's beak inspires UT Arlington research on water collection 2
... (Santa Barbara, Calif.) A newly discovered species of monitor ... in the journal Zootaxa this week by a ... Sam Sweet, a professor in the department of Ecology, ... graduate student at Abo Akademi University in Turku, Finland, are ...
... live in the nicest possible house, ideally with regular ... School of Arts and Sciences and the New England ... improved housing using previously unknown social networking skills. ... models to uncover some surprising new tricks that could ...
... MD The Genetics Society of America is pleased ... for poster awards at the 51st Annual Drosophila Research ... selected for first, second and third place awards for ... This was the first time that undergraduate student research ...
Cached Biology News:New monitor lizard discovered in Indonesia 2Social networking helps hermit crabs find homes 2Social networking helps hermit crabs find homes 3Genetics Society of America announces award recipients at 51st Annual Drosophila Conference 2
(Date:9/18/2014)... LOUIS , Sept. 18, 2014   ... announced today it has entered into a new ... (U-M) Medical School,s Vector Core. Under the partnership, ... CRISPR technology, experimental design consultation, and dedicated gene ... to accelerate gene editing-based research at the U-M ...
(Date:9/18/2014)... 2014 SeqLL Inc., the owner ... announced today the closing of a $1M Series-A ... Genomic Diagnostic Technologies, will increase the power of ... Founded in March 2013 by Daniel Jones, a ... Helicos BioSciences, SeqLL has continued to offer Helicos’ ...
(Date:9/18/2014)... a research lab can be pretty expensive. Now a ... has published an open-source library of designs that will ... piece of equipment: the syringe pump. , Syringe pumps ... for drug delivery or mixing chemicals in a reaction. ... dollars. , Joshua Pearce and his team of Michigan ...
(Date:9/18/2014)... new microscopy technology that allows them to view ... , Dubbed "Complementation Activated Light Microscopy" (CALM), the ... order of magnitude finer than conventional optical microscopy, ... at the nanometer scale. , In a paper ... , the researchers behind CALM used it to ...
Breaking Biology Technology:Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Doing science just got cheaper -- and faster 2Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2
... already. The first half stock market doesn't look pretty! The Dow ... up twice that level but took a tumble in May falling ... NASDAQ has really taken a hit in these first 6 months, ... increases, once again surpassing the $3/gallon level. This time, surprisingly, American ...
... one area biotech has resulted in a vertical move, but ... , ,And while GWC Technologies , a maker of ... not yet in the penthouse, the early-growth comany recently settled ... to president and CEO Tim Burland. , ,GWC, which was ...
... Milwaukee, Wis. - A Milwaukee-area producer of brain ... help expand its market share, and it did not ... , a company specializing in functional magnetic resonance imaging ... with Racine-based Ad-Tech Medical Instrument Co. to ...
Cached Biology Technology:First half of 2006 roundup: Big Pharma trumps biotech 2First half of 2006 roundup: Big Pharma trumps biotech 3First half of 2006 roundup: Big Pharma trumps biotech 4First half of 2006 roundup: Big Pharma trumps biotech 5First half of 2006 roundup: Big Pharma trumps biotech 6Madison biotech continues its climb 2Madison biotech continues its climb 3Madison biotech continues its climb 4