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Single microRNA causes cancer in transgenic mouse

val. Our transgenic mouse model clearly shows that miR155 is an oncogene, because it leads to B cell malignancies when it is dysregulated."

Although they now understand that miR 155 overexpression can lead to cancer, the researchers say they still haven't identified the exact mechanism that makes that happen. Still, the study suggests that a newly emerging class of artificially designed molecules (called antagomirs) may be able to block miR 155 expression and be an effective therapeutic strategy in patients with acute lymphoblastic leukemia or high grade lymphomas.


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Source:Ohio State University


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