Navigation Links
Single microRNA causes cancer in transgenic mouse

esearch associate, decided to isolate miR155 function by inserting the gene, along with an enhancer, to promote its expression, into fertilized eggs inside a pregnant mouse. The researchers then screened the offspring to find those that had incorporated miR155 into their genomes and followed them to see what effect miR155 might have.

Within three weeks, the transgenic mice developed greatly enlarged spleens, and after six to seven months, they became sick and died. Offspring that did not express miR 155 did not have enlarged spleens and developed normally.

When Costinean examined the spleens of the transgenic mice more closely, he discovered they were full of immature B cells ?and only immature B cells.

"This is significant, because a proliferation of these precursor B cells is one of the hallmarks of some types of leukemia and lymphoma," he said.

B cells, or lymphocytes, are white blood cells that help the body fight infection.

In humans, they are produced from stem cells in the bone marrow and then evolve through several stages before they become mature enough to create antibodies. Antibodies are proteins that sit on the surface of B cells or that are secreted by B cells that can detect the presence of foreign invaders like bacteria, viruses or parasites.

Lab tests revealed that the B cells in enlarged spleens had stopped evolving in the pre-B phase, right at the point where a B cell normally begins to create structures necessary for antibody development.

"We believe that miR 155 initiated the process that blocked further differentiation of these cells," says Costinean.

Croce says the results are consistent with previous study findings. "We know that miRNAs often act just like oncogenes, in that they promote abnormal cell growth that leads to cancer. Others, however, behave more like tumor suppressors, because they block genes that keep abnormal cell division in check or induce prolonged survi
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Single stem cells from bone heal a broken heart
3. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
4. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
5. Single gene is genetic switch for fly sexual behavior
6. Single cell amoeba increases MRSA numbers 1000- fold
7. Single molecular mark seen as pivotal for genome compaction in spores and sperm
8. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
9. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
10. Molecular steps involved in the creation of gene-silencing microRNAs identified
11. Scientists find microRNAs regulate plant development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Single microRNA causes cancer transgenic mouse

(Date:7/11/2014)... Researchers from Salk Institute for Biological Studies, BGI, ... the safety and reliability of the existing targeted ... method, TALEN-HDAdV, which could significantly increased gene-correction efficiency ... study published online in Cell Stell Cell ... cell-based gene therapy. , The combination of stem ...
(Date:7/11/2014)... risk of kidney injury related to the use of ... of HES molecules, according to a report in ... Anesthesia Research Society (IARS). , The "total mass of ... cultured human renal proximal tubule cells (PTCs), concludes the ... University Hospital Wrzburg, Austria. Other factorssuch as differences ...
(Date:7/11/2014)... Research and Markets has announced the addition ... Analysis Size Share Growth Trends and Forecast to 2019" ... http://photos.prnewswire.com/prnh/20130307/600769 The rising number of ... high level security in both private and public sector. ... and passwords, tokens etc. are vulnerable to attacks. Biometrics ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2
... have found a way to replace artificial preservatives in ... lab analyzing strains of mould fermented in sourdough bread, ... University of Alberta Department of Agricultural, Food and Nutritional ... compounds that can help keep bread fresh without changing ...
... Daejeon, Republic of Korea, February 25, 2013The Global Agenda ... the World Economic Forum (WEF), which is composed of ... announced today that the council has indentified "ten most ... for energy, food, nutrition, and health. These new technologies, ...
... French . For chronic pain sufferers, ... accident, avoiding the harmful effects of stress may be key ... with a smaller-than-average hippocampus, as these individuals seem to be ... study by Dr. Pierre Rainville, PhD in Neuropsychology, Researcher at ...
Cached Biology News:Top 10 ways biotechnology could improve our everyday life 2Top 10 ways biotechnology could improve our everyday life 3Top 10 ways biotechnology could improve our everyday life 4Preventing chronic pain with stress management 2
(Date:7/10/2014)... 2014 Unraveling life’s mysteries can intrigue, ... Archer Family purchased a DNA test to ... up with a lifetime of memories, sharing, and closeness. ... members’ DNA genuinely brought the family closer together. ... into genetic history and prior to taking the ...
(Date:7/10/2014)... Senior supply chain management executives from ... the challenges of “Reducing Cost, Lead Time, & Defects ... sourcing. Describing the partnership of the Bio Supply Management ... Institute ( SCMI) of the University of San ... the Kroc Institute of Peace and Justice in San ...
(Date:7/10/2014)... July 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, ... today announced an agreement with Lineagen, Inc., ... Lineagen,s NextStep Dx PLUS.  Lineagen, focused ... neurological disorders, currently offers FirstStep Dx ... service used by healthcare providers as a ...
(Date:7/10/2014)... may help in the fight against terrorism with the ... of explosives with the use of light and special ... and Actuators B: Chemical , the researchers describe a ... concentrations as low as 6.3 ppm (parts per million). ... minutes. , "Traditionally explosives detection has involved looking for ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2
... ShowPatrol and CardBrowser ... requirements and challenges of the search industry. , ... Cheshire, CT (PRWEB) April 8, 2010 -- ShowPatrol will be the ... responsible for all sales and marketing of the CardBrowser service to search firms and staffing ...
... ... , ... 7, 2010 -- Michael Sitaras showcased his professional tree care competency by ... International Society of Arboriculture (ISA). , , ,Michael developed his expertise as a ...
... ... Hermes Biosciences and partnership with sanofi-aventis , ... Cambridge, MA (PRWEB) April 7, 2010 -- Merrimack Pharmaceuticals, Inc., ... for cancer and inflammation, today announced that William Sullivan has been promoted to Vice ...
Cached Biology Technology:Danny Cahill announces new company ShowPatrol has partnered with CardBrowser 2Michael Sitaras of SavATree Earns ISA Certified Arborist Designation 2Merrimack Pharmaceuticals Promotes William Sullivan to Vice President of Finance 2
... System is ideal for developing single and ... system contains the new, improved, and user ... user can design specific templates for commercial ... fully integrated graphing and data regression capabilities; ...
... Sweep- based acquision and analysis ... response type applications. Contains powerful ... flexible analysis functions including automated ... plotting. Also includes many electrophysiology ...
EDG-6 Lysate Source: Cell Lysate Application: Western Blotting Control Form: IgG...
Madin-Darby bovine kidney (MDBK) cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Biology Products: