Navigation Links
Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes

Patients with type 1 diabetes who received islet transplantation from a single donor pancreas were insulin independent one year later, according to a study in the February 16 issue of JAMA, a theme issue on medical applications of biotechnology.

Type 1 diabetes remains a therapeutic challenge, according to background information in the article. The success rate of islet (cells that produce insulin to control blood sugar levels) transplants has recently been increased markedly by transplanting a higher number of islets prepared from 2 to 4 donor pancreases. However, for islet transplants to become a widespread clinical reality, additional advances are still needed. In particular, restoration of insulin independence must be achieved with a single donor, as is also the case with pancreas transplants, to reduce the risks and costs and increase the availability of islet transplantation.

Bernhard J. Hering, M.D., of the University of Minnesota, Minneapolis, and colleagues conducted a study to assess the effectiveness and safety of islet transplantation from a single pancreas. The trial was conducted from July 2001 to August 2003 and enrolled eight women with type 1 diabetes.

During the trial there were no serious, unexpected, or procedure- or immunosuppression-related adverse events. All eight recipients achieved insulin independence and freedom from hypoglycemia. Five remained insulin-independent for longer than 1 year.

"Our results mark a distinct advance in islet transplant efficacy. We not only achieved insulin independence using islets from only 1 donor pancreas [as compared with 2 to 4 in another trial], we also achieved superior glycemic control (as evidenced by normal results of oral glucose tolerance testing in 4 of 5 recipients with sustained insulin independence) using significantly fewer islets," the authors write. "These findings may have implications for the ongoing transition of islet transplantation from clinical investigatio n to routine clinical care."

"While these findings may suggest a distinct advance in islet transplantation, further study in a larger population with longer follow-up will be critical to assess the risk-benefit ratio of this emerging therapeutic option," the researchers conclude.


'"/>

Source:Journal Of The American Medical Association


Related biology news :

1. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
2. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
3. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
4. Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation
5. Procedure predicts embryos most likely to result in pregnancy
6. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
7. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
8. Novel Enzyme Shows Potential As An Anti-HIV Target
9. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
10. Special Imaging Study Shows Failing Hearts Are Energy Starved
11. Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/20/2016)... N.C. and GENEVA, Dec, 20, 2016 /PRNewswire/ ... biometric data sensor technology, and STMicroelectronics ... the spectrum of electronics applications, announced today the ... development kit for biometric wearables that includes ST,s ... with Valencell,s Benchmark™ biometric sensor system. ...
(Date:12/15/2016)... Germany , December 15, 2016 ... announced an agreement with NuData Security, an award-winning ... partnership will enable clients to focus on good customer experience, ... protection regulation. ... In order to provide a one-stop fraud prevention suite, ...
(Date:12/15/2016)... -- "Increase in mobile transactions is driving the growth ... is expected to grow from USD 4.03 billion in ... CAGR of 29.3% between 2016 and 2022. The market ... for smart devices, government initiatives, and increasing penetration of ... expected to grow at a high rate during the ...
Breaking Biology News(10 mins):
(Date:1/23/2017)... (PRWEB) , ... January 23, 2017 , ... ... replacement at the Caribbean Neurosciences Symposium (CANS) annual meeting in Montego Bay, Jamaica ... technology and host a hands-on workshop for surgeons to experience the simplicity of ...
(Date:1/21/2017)... ... ... Nipro Corporation (Osaka, Japan) and Transonic Systems Inc. (New York, USA) announced the ... sales rights for all non-OEM Transonic products in Japan. As partners for more than ... - Transonic JV is a natural next step to advance best practices and further ...
(Date:1/21/2017)... BOULDER, Colo. , Jan. 20, 2017 ... ("Bioptix" or the "Company"), announced that on January 14, ... a plan under which the Company will terminate certain ... subsidiary, Bioptix Diagnostics, Inc.  The Company commenced terminations on ... completed within 30 days.  The Company may pay severance ...
(Date:1/20/2017)... , ... January 20, 2017 , ... The two newest ... treatment options for patients. Vironika, a spin out from The Wistar Institute, and Sanguis, ... lab space at 3624 Market Street. , Vironika is developing a treatment for ...
Breaking Biology Technology: