Navigation Links
Simple sea sponge helps scientists understand tissue rejection

Understanding why some transplant patients reject their new organs requires a working knowledge of how cells recognize and accept or reject each other. Xavier Fernndez-Busquets, an MBL researcher visiting from the University of Barcelona, has found the perfect ally in this quest: the red beard sea sponge, an Atlantic species that grows abundantly from just north of Cape Cod down to Florida.

The red beard sponge (Microciona prolifera) has a cell-to-cell recognition system that, on a basic level, is similar to that of humans but much simpler. It's also a good organism for laboratory research, since its cells and cell adhesion molecules can be isolated with simple, fast, and non-disruptive methods and studied, and because its fingerlike structures make grafting experiments relatively straightforward.

In experiments carried out on these sponges this summer, Dr. Fernndez-Busquets and his colleagues are studying the cells and molecules believed to be involved in the process of tissue rejection. By grafting together pieces of different individual sponges that will reject each other--a process that approximates what sometimes happens in human transplants--the scientists have observed that cells known as gray cells migrate to and amass at the graft site, a clear suggestion that they are involved in non-self tissue recognition and rejection. Researchers believe that gray cells may be a primitive form of our immune system's human killer cells.

Fernndez-Busquets has also been researching the role of the molecule called aggregation factor proteoglycan, which he has recently identified as another potential player in sponge tissue rejection reactions, and which is very easy to study in sponges. The human version of this molecule, which is different from the sponge version but similar in structure, is also believed to have important functions in cell-to-cell interactions, but is hard to study.

The ultimate goal of this research is to provide insights into the machinery behind human tissue rejection and immune responses in hopes of someday being able to control these processes and save lives.


'"/>

Source:Marine Biological Laboratory


Related biology news :

1. Simple drug has the potential to save many lives threatened by malaria
2. Discovery Promises Simpler Therapy for Sickle Cell Disease
3. Simple explanation for complex pattern of feather development
4. Simple idea to dramatically improve dengue vaccinations
5. Simple home spit test to spot deadly pre-eclampsia
6. Marine sponge yields nanoscale secrets
7. Hidden sponges determine coral reefs nutrient cycle
8. Jumping gene helps explain immune systems abilities
9. Protein helps regulate the genes of embryonic stem cells
10. Scientists reveal the shape of a protein that helps retroviruses break into cells
11. Thai spice helps cut blood sugar swings
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... (NYSE: DAL ) customers now can use fingerprints instead of ... Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May ... boarding process to allow eligible Delta SkyMiles Members who are enrolled in ...
(Date:6/14/2017)... June 15, 2017  IBM (NYSE: IBM ) is introducing ... event dedicated to developing collaboration between startups and global businesses, ... 15-17. During the event, nine startups will showcase the solutions ... various industries. France ... market, with a 30 percent increase in the number of ...
(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The ... endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. ... is transformative for performing systematic gain-of-function studies. , This complement to loss-of-function ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017  SkylineDx ... London (ICR) and University of Leeds ... to risk-stratify patients with multiple myeloma (MM), in a multi-centric ... The University of Leeds is the ... UK, and ICR will perform the testing services to include ...
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
(Date:10/10/2017)... BARBARA, CALIFORNIA (PRWEB) , ... October 10, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation ...
Breaking Biology Technology: