Navigation Links
Simple sea sponge helps scientists understand tissue rejection

Understanding why some transplant patients reject their new organs requires a working knowledge of how cells recognize and accept or reject each other. Xavier Fernndez-Busquets, an MBL researcher visiting from the University of Barcelona, has found the perfect ally in this quest: the red beard sea sponge, an Atlantic species that grows abundantly from just north of Cape Cod down to Florida.

The red beard sponge (Microciona prolifera) has a cell-to-cell recognition system that, on a basic level, is similar to that of humans but much simpler. It's also a good organism for laboratory research, since its cells and cell adhesion molecules can be isolated with simple, fast, and non-disruptive methods and studied, and because its fingerlike structures make grafting experiments relatively straightforward.

In experiments carried out on these sponges this summer, Dr. Fernndez-Busquets and his colleagues are studying the cells and molecules believed to be involved in the process of tissue rejection. By grafting together pieces of different individual sponges that will reject each other--a process that approximates what sometimes happens in human transplants--the scientists have observed that cells known as gray cells migrate to and amass at the graft site, a clear suggestion that they are involved in non-self tissue recognition and rejection. Researchers believe that gray cells may be a primitive form of our immune system's human killer cells.

Fernndez-Busquets has also been researching the role of the molecule called aggregation factor proteoglycan, which he has recently identified as another potential player in sponge tissue rejection reactions, and which is very easy to study in sponges. The human version of this molecule, which is different from the sponge version but similar in structure, is also believed to have important functions in cell-to-cell interactions, but is hard to study.

The ultimate goal of this research is to provide insights into the machinery behind human tissue rejection and immune responses in hopes of someday being able to control these processes and save lives.


'"/>

Source:Marine Biological Laboratory


Related biology news :

1. Simple drug has the potential to save many lives threatened by malaria
2. Discovery Promises Simpler Therapy for Sickle Cell Disease
3. Simple explanation for complex pattern of feather development
4. Simple idea to dramatically improve dengue vaccinations
5. Simple home spit test to spot deadly pre-eclampsia
6. Marine sponge yields nanoscale secrets
7. Hidden sponges determine coral reefs nutrient cycle
8. Jumping gene helps explain immune systems abilities
9. Protein helps regulate the genes of embryonic stem cells
10. Scientists reveal the shape of a protein that helps retroviruses break into cells
11. Thai spice helps cut blood sugar swings
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/17/2016)... Global Market Watch: Primarily supported by ownership types; ... Academics) market is to witness a value of US$37.1 billion ... Compounded Annual Growth Rate (CAGR) of 10.75% is foreseen from ... 2014-2020. North America is not way ... Europe at 9.56% respectively. Report Focus: ...
(Date:11/15/2016)... , Nov. 15, 2016  Synthetic Biologics, Inc. ... therapeutics focused on the gut microbiome, today announced ... 25,000,000 shares of its common stock and warrants ... at a price to the public of $1.00 ... Synthetic Biologics from the offering, excluding the proceeds, ...
(Date:11/14/2016)... SANTA CLARA, Calif. , Nov. 14, ... of the biometric identification market, Frost & ... Global Frost & Sullivan Award for Visionary ... leading player in the biometric identification market ... a multi-modal verification solution for instant, seamless, ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... 01, 2016 , ... DrugDev believes the only way to achieve ... experience. All three tenets were on display at the 2nd Annual DrugDev User Summit ... sponsor, CRO and site organizations to discuss innovation and the future of clinical research. ...
(Date:12/2/2016)... , ... December 02, 2016 , ... Robots will storm ... on December 3rd, 2016. The event, which is held on the United Nations ... helping Americans with Disabilities back into the workplace. Suitable Technologies is partnering with NTI ...
(Date:12/2/2016)... RICHMOND, BC , Dec. 2, 2016 /PRNewswire/ - bioLytical Laboratories, a world leader ... Test, to Kenya,s Pharmaceutical Association members. (Photo: ... ... , , ... Initiative (CHAI) and the Kenya Pharmaceutical Association (KPA) to introduce the INSTI HIV Self ...
(Date:11/30/2016)... York , November 30, 2016 ... as a few players hold a dominant share in ... Charles River Laboratories International, Inc., and Merck KGaA, held ... in 2015. Transparency Market Research observes that these companies ... focused on development products that are do not require ...
Breaking Biology Technology: