Navigation Links
Simple idea to dramatically improve dengue vaccinations

s when the immune system identifies infected cells and brings pieces of them into the lymph node for targeting. Within a few days of infection, the immune system completes a massive scan of the 100 million available T-cells in its arsenal. Through a complex trial-and-error process, it identifies three to five T-cells that best recognize and attack the components of the sickened cells. Once the cells are selected, they are produced by the millions and sent out to clear the infection. After the infection is gone, thousands of these pre-programmed T-cells remain in the body, lying in wait should the disease return.

In recent years, public health officials have documented the disturbing co-existence of two or more Dengue viruses in Brazil, Cuba, Thailand, and other tropical and subtropical countries. Because sequential infection by multiple Dengue viruses can lead to increased likelihood of deadly infections, public health officials have attempted to counter the threat of co-existent versions of Dengue by developing a vaccine against all four versions simultaneously. Doctors found that patients who got a four-component vaccine wound up only being protected against one or two versions at most, due to immunodominance.

Intrigued by these results, Deem and graduate student Hao Zhou developed a precise computer model of the immune system's biochemical scanning process to see if they could recreate the effect and find out what caused it. Their program conducts statistical calculations about the likelihood of specific interactions at the atomic level. They conducted trillions of calculations and gradually built up a bigger picture of what occurs in Dengue immunodominance.

"When faced with more than one version of the virus, the immune system may respond preferentially against the version for which it has T-cells with the strongest affinity, which is immunodominance," Deem said.

He said polytopic vaccination ?giving different vaccines simultaneou
'"/>

Source:Rice University


Page: 1 2 3

Related biology news :

1. Simple drug has the potential to save many lives threatened by malaria
2. Discovery Promises Simpler Therapy for Sickle Cell Disease
3. Simple sea sponge helps scientists understand tissue rejection
4. Simple explanation for complex pattern of feather development
5. Simple home spit test to spot deadly pre-eclampsia
6. New miniaturised chip dramatically reduces time taken for DNA analysis
7. Caloric restriction wont dramatically extend life span in humans: UCLA research
8. Hospitalizations because of chicken pox down dramatically since implementation of vaccine
9. Lack of a key enzyme dramatically increases resistance to sepsis
10. Smoking ban dramatically reduces air pollution in Irish pubs
11. Growing nerve cells in 3-D dramatically affects gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Simple idea dramatically improve dengue vaccinations

(Date:12/5/2014)... 2014 Increased emphasis on product quality, ... testing and inspection technologies. The convergence of industries ... range of innovative test solutions. This trend is ... which is generally more inclined towards communication, media ... strategies of test equipment vendors will cater to ...
(Date:11/21/2014)... According to a new market research report ... Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), End ... - Global Forecasts to 2020", published by MarketsandMarkets, The ... $25 Billion in 2014 and is expected to reach ... 8.69%. Browse 116 market data Tables and ...
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... Calif.) Carbon dioxide emissions from transportation, energy generation ... change, but they may not be the biggest ones. ... A. Cleveland, that dubious distinction could go to the ... a Planet: The Future of Food and Agriculture," Cleveland ...
... The University of Liverpool has been awarded 4million for a ... of preventing the spread of bacterial, viral and fungal infections. ... design and develop a new generation of surfaces and materials ... There is significant global demand for products that prevent ...
... Risk scores for diseases such as CVD are usually presented ... next ten years. The Heart Age Calculator, http://www.heartage.me , ... an individual,s risk score as their estimated Heart Age to ... Cardiovascular disease (CVD) is the world,s biggest ...
Cached Biology News:Book empowers readers to help solve the food crisis 2Book empowers readers to help solve the food crisis 3People who know their 'heart age' make greater improvements to their heart health 2
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ... The only negative is the housing market remaining soft. ...
(Date:12/24/2014)... Nashville, Tenn. (PRWEB) December 23, 2014 ... Hill was elected treasurer for the American Society ... to advancing knowledge and research in reproductive medicine. ... fills a seat on the executive board and will ... , Dr. Hill has actively supported ASRM since ...
(Date:12/24/2014)... 2014 Pipette.com announces their Holiday ... can submit their #HolidayInTheLab pictures for a chance to ... , For those struggling to think of a holiday ... in the Lab Contest provides the ideal holiday presents. ... to send pictures of their chemistree, holiday sweaters, as ...
(Date:12/24/2014)... Texas , Dec. 23, 2014 ... company focused on gynecologic disease, announced today that ... Schuler , Birchview Fund LLC and several Vermillion ... of unregistered shares of Vermillion,s common stock and ... stock in a private placement.  ...
Breaking Biology Technology:ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... given,that Finkelstein Thompson LLP has filed a Class Action ... District of Washington on,behalf of a class (the "Class") ... acquired the common stock of CellCyte Genetics,Corporation ("CellCyte" or ... and January 9, 2008 inclusive (the "Class Period")., ...
... Calif., Feb. 5 DURECT Corporation,(Nasdaq: DRRX ) ... ended December 31, 2007. Total revenues were $6.6 million ... $5.4 million for the same,period in 2006. Net loss ... million, compared to a net loss of $9.8 million ...
... CardioTech,International, Inc. (Amex: CTE ), a developer ... the treatment of cardiovascular and other,diseases, announced today ... financial results before the market opens on Tuesday, ... host a conference call for,investors at 2:30 p.m. ...
Cached Biology Technology:Finkelstein Thompson LLP Announces Filing of Securities Fraud Class Action Against CellCyte Genetics Corporation 2DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 2DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 3DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 4DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 5DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 6DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 7DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 8DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 9CardioTech Announces Conference Call on February 12 at 2:30 PM Eastern for Third Quarter of Fiscal 2008 2
Weinreb Linker...
...
Rabbit polyclonal to M13 Bacteriophage Coat Proteins ( Abpromise for all tested applications)....
Recognizes the 41 and 43 kDa G-proteins present in liver plasma membranes and Gq/11alpha expressed in the Sf9 insect cell expression system. Negative for recombinant G(I)alpha subtypes....
Biology Products: