Navigation Links
Simple explanation for complex pattern of feather development

Biologists testing a mathematical model of the mechanism birds use to control the growth of complex feathers found that plumed feather structures involve the coordination of at least two genes that activate and that inhibit barb growth.

"Understanding these mechanisms of feather growth gives a whole new perspective on the unique beauty of feathers," said Richard Prum, senior author on the study. Prum is the William Robertson Coe Professor of Ornithology, and Curator of Ornithology and Vertebrate Zoology at Yale's Peabody Museum of Natural History.

An eclectic team of biologists used a combination of mathematical and molecular methods to reveal some of the secrets of branched feather growth, and propose how the unique complexity of feathers may have evolved. Ornithologist Prum led a team including anatomists Matthew Harris and John Fallon at the University of Wisconsin, statistician Scott Williamson at Cornell and Hans Meinhardt at the Max Plank Institute.

Their findings provide the best experimental evidence for a classical theory for growth of complex biological structures. In the 1950's, Alan Turing, mathematician, pioneering computer scientist and code-breaker, proposed that repeated patterns could emerge through the interactions among chemical morphogens or molecules that cause things to develop -- an activator that makes things happen, and an inhibitor that suppresses the activator.

To test the model in feathers, Harris forced expression of the activator, Shh, or the inhibitor, Bmp2, in the skin of six-day old chick embryos by injecting them with a retrovirus. The results were seen in localized patches and demonstrated that a simple relationship between developmental genes could be the basis for formation of feather structures. This was the first documentation, in any plant or animal, that signaling molecules in development can actually behave as envisioned by Turing 50 years ago.

This work provides a key to some of these most basic questions of biology. The findings also indicate that more complex shafted feathers evolved from the simpler downy tufts by the addition of new players to the original activator-inhibitor pair. Prum is now following up on several clues in the search for these other molecular signals.


'"/>

Source:Yale University


Related biology news :

1. Simple drug has the potential to save many lives threatened by malaria
2. Discovery Promises Simpler Therapy for Sickle Cell Disease
3. Simple sea sponge helps scientists understand tissue rejection
4. Simple idea to dramatically improve dengue vaccinations
5. Simple home spit test to spot deadly pre-eclampsia
6. Nobel Laureate finds elegant explanation for DNA transcribing enzymes high fidelity
7. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
8. Scientists document complex genomic events leading to the birth of new genes
9. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
10. MSKCC researchers uncover structure of key protein complex in cells
11. Mouse genome much more complex than expected
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2016)... , June 16, 2016 ... is expected to reach USD 1.83 billion by ... View Research, Inc. Technological proliferation and increasing demand ... are expected to drive the market growth. ... The development of advanced multimodal techniques ...
(Date:6/3/2016)... June 3, 2016 ... Nepal hat ein ... hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und ... der Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche ... im Januar teilgenommen, aber Decatur wurde als ...
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of ... the latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Medical Display- Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... , ... Parallel 6 , the leading software as a service (SaaS) ... Virtual Patient Encounter CONSULT module which enables both audio and video telemedicine communication between ... Using the CONSULT module, patients and physicians can schedule a face to face virtual ...
(Date:6/27/2016)...  Liquid Biotech USA , ... Sponsored Research Agreement with The University of Pennsylvania ... cancer patients.  The funding will be used to ... clinical outcomes in cancer patients undergoing a variety ... employed to support the design of a therapeutic, ...
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader in clinical ... Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits ... tips, tools, and strategies for clinical researchers. , “The landscape of how patients ...
Breaking Biology Technology: