Navigation Links
Silence of the amoebae

Freedom of expression is great, but silence is golden ?at least when it comes to amoebae, which are intestine-dwelling parasites that cause life-threatening dysentery in many parts of the world. Three years ago, scientists at the Weizmann Institute accidentally discovered a way to silence the expression of a key amoebic gene, one which codes for a toxic protein that kills human intestinal cells infected with this devastating illness. Now the scientists have developed a way to successfully silence the expression of two additional virulence genes in the same amoebae.

Rivka Bracha and colleagues in the lab of Prof. David Mirelman in the Biological Chemistry Department had shown that expression of the gene coding for the toxic protein could be prevented by inserting a plasmid (a small loop of DNA) containing a copy of a specific part of that gene into the amoeba cell nucleus. Introducing the plasmid led to the modification of DNA "packing" proteins, causing the DNA-protein packages to become more tightly coiled ?something like a tangled telephone cord ?and causing an irreversible silencing of gene expression. In a recent paper published in PLoS Pathogens, the Weizmann scientists report the silencing of two additional virulence genes in the same amoebae using a similar plasmid-induced principle.

The disabled amoebae, though rendered harmless, still display the same repertoire of surface antigens (markers recognized by the immune system) as the disease-causing strain. The scientists now plan to test the ability of these silenced amoebae to serve as a live vaccine by evoking an intestinal immune response. If successful, it may put an end to amoebic diseases that claim the lives of thousands yearly and afflict millions more.
'"/>

Source:American Committee for the Weizmann Institute of Science


Page: 1

Related biology news :

1. Silence the gene, save the cell: RNA interference as promising therapy for ALS
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... BETHESDA, Md. , June 22, 2016  The American ... by Trade Show Executive Magazine as one of ... Summit on May 25-27 at the Bellagio in ... based on the highest percentage of growth in each of ... number of exhibiting companies and number of attendees. The 2015 ...
(Date:6/22/2016)... 2016 On Monday, the Department of Homeland ... share solutions for the Biometric Exit Program. The Request ... Protection (CBP), explains that CBP intends to add biometrics ... the United States , in order to deter ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring announced that after ... secured the final acceptance by all three (3) ... Systems (MAS) installed. Furthermore, Securus will have contracts ... by October, 2016. MAS distinguishes between legitimate wireless ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , ... announced today the Clinical Reach Virtual Patient Encounter CONSULT module which enables ... the physician and clinical trial team. , Using the CONSULT module, patients and physicians ...
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
Breaking Biology Technology: