Navigation Links
Signaling protein builds bigger, better bones in mice

In a new study, researchers present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer.

In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimental test intended to identify early ovarian cancer from a small sample of blood is unlikely to lead to a reliable clinical test right away.

After conducting repeated checks of the data that supported the test’s effectiveness, the researchers say their findings indicate that claims about the experimental protein-based assay are not biologically plausible.

“We view this as a cautionary tale. If you are not careful with this new technology, whose quirks we don’t fully understand, you can find results that may be due to something other than biology,?says the study’s lead author, Keith Baggerly, Ph.D., an associate professor in the Department of Biostatistics & Applied Mathematics.

He adds that this study “illustrates the need for researchers to set standards by which to conduct proteomics research,?meaning that protocols involved in these investigations should be common across laboratories so that results from one lab can be verified by others.

"We are moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting better and we are getting more reproducible results.?
Researchers worldwide are excited about the notion of using protein “barcodes?to identify individual cancers before symptoms appear, but Baggerly and others maintain that the promise of this emerging field of proteomics has not yet been met due to the difficulty in finding complex, reproducible patterns of proteins.

According to Baggerly, that now appears to be the case with the experimental ovarian cancer test at issue, which was first proposed in 2002 by researc
'"/>

Source:


Page: 1 2 3

Related biology news :

1. Computational Method Speeds Mapping of Cell Signaling Networks
2. Signaling for cartilage
3. New, automated tool successfully classifies and relates proteins in unprecedented way
4. New binding target for oncogenic viral protein
5. Controversial drug shown to act on brain protein to cut alcohol use
6. Timing is everything: First step in protein building revealed
7. UWs Rosetta software to unlock secrets of many human proteins
8. Researchers find how protein allows insects to detect and respond to pheromones
9. Ancient olfaction protein is shared by many bugs, offering new pest control target
10. Automatic extraction of gene/protein biological functions from biomedical text
11. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Signaling protein builds bigger better bones mice

(Date:7/22/2014)... a cost-effectiveness analysis of commercial diet programs and pills, ... the best value for the money. The Jenny Craig ... the most expensive option tested, according to researchers at ... The findings, published in the June issue of the ... health and weight-loss benefits per dollar spent as insurance ...
(Date:7/22/2014)... squirrels have adapted to New York City,s human behaviour, ... better, than their fellow squirrels in the woods. , ... Environment & Agriculture, led the study that proved eastern ... urban environments and prevent unnecessary responses when humans acted ... footpath. , "As we rapidly increase the spread ...
(Date:7/22/2014)... a child,s lunch box and you,re likely to find that ... Those are the findings of a study conducted by researchers ... Tufts University and in the Department of Public Health and ... findings are published online ahead of print in the ... , Led by senior author Jeanne Goldberg, Ph.D., R.D., a ...
Breaking Biology News(10 mins):Study compares cost-effectiveness of weight-loss programs and drugs 2Study compares cost-effectiveness of weight-loss programs and drugs 3New York squirrels are nuts about city life 2Room for improvement in elementary school children's lunches and snacks from home 2
... CINCINNATIWith the discovery of a RNA nano-scaffold that remains ... of Cincinnati (UC) have overcome another barrier to the ... Dane and Mary Louise Miller Endowed Chair and professor ... of Engineering and Applied Sciences report the construction of ...
... drilling rig exploded on April 20, 2010, in the ... planetary sciences at the University of Tennessee, Knoxville, grabbed all ... the Louisiana coast. Engel and dozens of scientists ... they knew would be needed once the oil began spilling ...
... of white LED bulbs, it turns out, suppresses melatonin 5 ... Sodium bulbs that give off an orange-yellow light. "Just as ... also be regulations and rules for the pollution stemming from ... University of Haifa. , "White" light bulbs that emit ...
Cached Biology News:Team finds stable RNA nano-scaffold within virus core 2UT researcher investigates Deepwater Horizon oil spill impact on coast 2Dangers of exposure to 'white' light 2Dangers of exposure to 'white' light 3
(Date:7/22/2014)... The DNA Spectrum Ancestry Map ... of history, migration, and culture. , Throughout his ... history stories stemming from Europe. His father passionately referred ... and 8mm home movies painted an elaborate picture of ... Steve ordered a test from DNA Spectrum to expand ...
(Date:7/22/2014)... CAMBRIDGE, Massachusetts e SHENZHEN ... Solutions Co., LTD, (BGI Tech), una filiale di BGI, ... il lancio mondiale di un nuovo servizio di sequenziamento ... settore di Complete Genomics. Complete Genomics, ... fornire tecnologie di sequenziamento proprietarie con il 99.999% di ...
(Date:7/22/2014)... Ore. , July 22, 2014  Semler ... an emerging medical risk assessment company that develops ... patients and evaluating chronic diseases, today announced that ... before the open of U.S. financial markets on July ... Semler will host a conference call at 11 a.m. ...
(Date:7/22/2014)... New Jersey , 22. Juli 2014 /PRNewswire/ ... die Life-Sciences-Industrie, hat die Ernennung von Marcus Bergler ... bekanntgegeben. Herr Bergler hat die europäischen kommerziellen Aktivitäten ... unterstützt. Bevor er sich Qforma anschloss, war er ... Cegedim Customer Information, als Vertriebsteam-Leiter Deutschland bei IMS ...
Breaking Biology Technology:DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 2DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 3DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 4BGI Tech lancia un servizio di sequenziamento dell'intero esoma umano sulla piattaforma avanzata di Complete Genomics 2Semler to Report Second Quarter 2014 Financial Results and Host Conference Call on July 25, 2014 2Qforma gibt Schaffung des neuen Postens als General Manager in Europa bekannt 2
... IRVINE, Calif., March 10 Diabetes will be ... plan to expand and improve healthcare coverage. ... located in Irvine, California, has developed a new ... of diabetes on our healthcare system.(Photo: ...
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) ... and Company 29th Annual Health Care Conference on Tuesday, ... parties may access a live webcast of the presentation ... is recommended that listeners log on 15 minutes early ...
... /PRNewswire-FirstCall/ -- Nektar Therapeutics, (Nasdaq: ... Robin, is scheduled to present at the upcoming Cowen and ... Marriott Copley Plaza on Monday, March 16, 2009 at 2:25 ... through a link posted on the Investor Relations, Events Calendar ...
Cached Biology Technology:Can Obama Plan Tackle Diabetes Crisis? Epinex Test Could Help 2
... Adhesive seal tabs • Reusable, ... can be quickly assembled and disassembled for ... specimens of any thickness with up to ... three chambers per slide. Minimize specimen handling, ...
Comp Dim: chamber diam. depth 20 2.8 mm chamber maximum volume 720 μL...
...
... assays, all EIA/RIA plates are manufactured from ... optical clarity and low background absorption. In ... Certified Surface Chemistry Programme, which guaarantees protein ... specifications. Linkage: This CLS number is a ...
Biology Products: