Navigation Links
Signaling for cartilage

Skeletal progenitor cells differentiate into cartilage cells when one master gene actually suppresses the action of another, said Baylor College of Medicine researchers in a report that appears online in the journal Proceedings of the National Academy of Sciences.

Skeletons are made of bone and cartilage cells that are differentiated from the same multipotent stem cell, said Dr. Brendan Lee, associate professor of molecular and human genetics at BCM, director of the Skeletal Dysplasia Clinic at Texas Children’s Hospital and a Howard Hughes Medical Institute investigator. This same stem cell gives rise to bone, cartilage, fat and fibroblasts.

“The big question is what are the master genes that make a stem cell go one way versus another,?said Lee.

Both SOX9 and RUNX2 are master transcription factors involved in the process of differentiating bone and cartilage.

The master protein SOX9 directs skeletal progenitor cells to become cartilage and another master protein, RUNX2, directs such cells to become bone, However, he said, the primordial skeletal cell has both RUNX2 AND SOX9.

“We then asked a simple question: Could these master transcription factors (that direct the expression of other genes) directly affect one another’s function"?he said. After studies in the laboratory, with mice and with humans, the answer was yes.

“SOX9 appears to be the dominant player,?said Lee. “When it is present in a progenitor cell, it turns off RUNX2 and allows the cell to become cartilage.?

That does not answer the question of how such cells become bone.

“Clearly, something must turn off SOX9,?said Lee. “That’s the next question we have to answer.?

Working in a genetic lab allowed Lee and his colleagues to learn from gene-caused diseases of the skeletal system. Studies of human tissues proved that the protein activity identified in cells in the laboratory and in studies with mice occurred in humans as we ll.
'"/>

Source:Baylor College of Medicine


Related biology news :

1. Signaling protein builds bigger, better bones in mice
2. Computational Method Speeds Mapping of Cell Signaling Networks
3. Scientists use stem cells to grow cartilage
4. Stem cells from muscles can repair cartilage
5. Bioengineered tissue implants regenerate damaged knee cartilage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/21/2019)... ... January 20, 2019 , ... Energetiq Technology, a world leader in ... at the SPIE BIOS and SPIE Photonics West events taking place in San Francisco ... booth #8526 at Bios and in booth #941 at Photonics West. There will be ...
(Date:1/20/2019)... SAN DIEGO (PRWEB) , ... January 16, 2019 , ... ... building and cooking events company. Not only has the company already hosted several ... to host Fortune 500 companies, Amazon and Janssen Pharmaceuticals, later this month. , ...
(Date:1/14/2019)... ... 14, 2019 , ... CellMax Life , a diagnostics ... will present new findings at the ASCO Gastrointestinal Cancer Symposium in San Francisco ... from this study show CellMax Life’s blood test, based on its proprietary CMxTM ...
Breaking Biology News(10 mins):
(Date:1/24/2019)... ... January 22, 2019 , ... Outsourcing trials ... own set of assumptions, and RFP creation and management generally requires manual effort. ... comparing apples to oranges. These challenges can ultimately lead to study start delays ...
(Date:1/20/2019)... ... January 16, 2019 , ... On January 15 of this ... article by Asymmetrex director James L. Sherley, M.D., Ph.D. The PGCB ... like the PGCB and CellTrials.org. Now in its 21st year of operation, the ...
(Date:1/20/2019)... ... January 17, 2019 , ... Today, Advanced Solutions, Inc., a ... specialized automation technology, titled Automate 3D. Automate 3D, produced by Advanced Solutions, allows ... to deliver to end-users, customers, and ERP systems. , Automate 3D ...
(Date:1/15/2019)... ... ... Congress designating January as Cervical Health Awareness Month , myLAB Box , ... the risk of Cervical Cancer. , Cervical cancer is a slow-growing cancer that ... STD and an STI that almost half of all American adults have. While there ...
Breaking Biology Technology: