Navigation Links
Signal protein shows promise for blocking tumor promoters in skin cells

s on the skin. These plaques, or lesions, resembled precursors of cancer. Breeding experiments with the mice indicated that high Srcasm levels counteracted the effects of Fyn.

The findings reveal that levels of Fyn and Srcasm work in a kind of see-saw ?when Srcasm production is low, dangerous amounts of Fyn can build up in cells. But when Srcasm production is increased, Fyn levels go down. "The binding of Srcasm to Fyn regulates Fyn's persistence in the cell," says Seykora. "If Srcasm is low, Fyn persists longer and sends more growth-promoting signals."

Reversing Tumors
Eventually, Srcasm might play a role in targeted gene therapies for cancers that are triggered by activated Src kinases. Such a therapy would likely use an adenovirus to carry a gene that codes for Srcasm into skin cells to increase Srcasm production, as used in some other gene therapy treatments. Initially, clinicians may try this method on oral cavity and skin cancers.

Next, the Penn researchers will determine whether Srcasm can actually reverse tumor formation in skin. Seykora's team has already prepared an adenovirus and mice with the tumor-forming Src kinases expressed in their skin. Within six months, the group expects to know whether Srcasm can decrease squamous cell carcinoma formation in skin, mentions Seykora.
'"/>

Source:University of Pennsylvania School of Medicine


Page: 1 2

Related biology news :

1. Signaling protein builds bigger, better bones in mice
2. Computational Method Speeds Mapping of Cell Signaling Networks
3. Signaling for cartilage
4. New, automated tool successfully classifies and relates proteins in unprecedented way
5. New binding target for oncogenic viral protein
6. Controversial drug shown to act on brain protein to cut alcohol use
7. Timing is everything: First step in protein building revealed
8. UWs Rosetta software to unlock secrets of many human proteins
9. Researchers find how protein allows insects to detect and respond to pheromones
10. Ancient olfaction protein is shared by many bugs, offering new pest control target
11. Automatic extraction of gene/protein biological functions from biomedical text
Post Your Comments:
(Date:11/21/2014)... 19, 2014  Earlier this year Donald Spector ... and one of the most prolific inventors in the ... transmitted from Smartphones to third party agencies. Spector envisioned ... one of the earliest known patents in this area. ... the military, child care, elder care and hospital applications. ...
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, ... the Internet of Things (IoT), today announced the appointment ... chief operating officer. Previously a strategic advisor to the ... and operations. Mr. Traynor is based out of the ... He reports to Chris Muench , Chief Executive ...
(Date:11/18/2014)...  The Secure Identity & Biometrics Association (SIBA) ... the formation of The Airport Entry and Exit ... and Biometric Entry and Exit Solutions Framework for ... from BORDERPOL, the international non-profit organization that works ... regarding border security, traveler and migration systems. ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... Abnormalities in cardiac conduction, the rate at which ... are a major cause of death and disability around ... developing a new method, Electromechanical Wave Imaging (EWI), that ... activation of the heart. Based on ultrasound imaging, EWI ...
... to impair normal muscle function in rats, an ... according to Penn State researchers. "Our findings demonstrate ... and carrying excess weight," said Rudolf J. Schilder, ... Penn State College of Medicine. "We show that, ...
... Hopkins scientists have discovered how two closely related proteins ... attracting and repelling these axons as they navigate the ... to make remarkably precise connections. The discovery, reported ... that proteins belonging to the "semaphorin" family of guidance ...
Cached Biology News:Columbia engineers develop new method to diagnose heart arrhythmias 2Obesity creates wimpy rats 2Johns Hopkins scientists reveal nerve cells' navigation system 2Johns Hopkins scientists reveal nerve cells' navigation system 3
(Date:11/21/2014)... (PRWEB) November 20, 2014 BlueInGreen, ... Ozone Solutions, LLC (Pinnacle), and PCI, Inc., leading ... that they have been selected to provide a ... Fayetteville, Arkansas Paul R. Noland Wastewater Treatment. ... patented HyDOZ® gas dissolution technology, Pinnacle ...
(Date:11/21/2014)... November 21, 2014 2014 Deep ... Industryā€¯ is a professional and in-depth research report ... ferrocyanide information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
(Date:11/21/2014)... , Nov. 20, 2014 Polaris ... been dosed in its Phase 1 trial of ... for the treatment of malignant pleural mesothelioma (MPM) ... is conducting clinical trials on ADI-PEG 20, both ... for the treatment of several other indications, including ...
(Date:11/21/2014)... , Nov. 20, 2014  Cytori Therapeutics (NASDAQ: ... Hedrick , M.D. will present live at VirtualInvestorConferences.com on December ... TIME:    11:15 am PT / 2:15 pm ET ... into your browser,s address bar: http://bit.ly/1B2KGaL ... receive event updates. This will be a ...
Breaking Biology Technology:City of Fayetteville Leads Nation with Innovative Ozone Technology 2City of Fayetteville Leads Nation with Innovative Ozone Technology 3City of Fayetteville Leads Nation with Innovative Ozone Technology 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4
... PRA International, a leading Clinical Research Organization, announces it ... Meeting April 28-30, 2009 in Orlando Florida. PRA,s Greg ... " RFP Management & Contracting with CROs to Minimize ... Drawing on his extensive experience with contracting, Mr. Guarasci ...
... 2009 edition of the,Biotechnology Industry Organization (BIO) Conference ... 18th-20th. Genopole(R) will participate in this,major event as ... Region.,Seven of Genopole(R),s innovative companies (BioQuanta, Drugabilis,GenOptics, Innavirvax, ... will, attend. , The ...
... SQNM ), today announced that it will report first ... 2009. The company will conduct a conference call and an ... on the same day., Conference Call Information:, ... callers: 1 (706) 679-9912, , , Webcast information: ...
Cached Biology Technology:PRA International Presents Key Budgeting Strategies at 18th Annual CRO Partnerships Conference 2Genopole(R) to Accompany 7 Companies and a Research lab to BIO Atlanta 2SEQUENOM to Hold First Quarter 2009 Financial Results Conference Call on April 30 2
... affinity chromatography, Affi-Prep protein A media ... remove IgG prior to analysis of ... complexes for antigen purification. Protein A ... immunoglobulins, especially IgG from mammalian species. ...
... introduce its new line of Protein Standards, ... for use in mass spectrometry, molecular biology, ... Standards are high quality purified proteins for ... by electrospray ionization mass spectrometry (ESI-MS). ...
... White solid. HYGROSCOPIC. A non-ionic ... reduced electrostatic interactions that do not interfere ... number: 8-16. Purity: ≥95% by HPLC. ... number 8 - 16, CMC 1.1 - ...
Determine relative degree of protein binding to phosphoinositides...
Biology Products: