Navigation Links
Sickle cell and protection against malaria

In this month's issue of the freely available online journal PLoS Medicine, Dr. Thomas N. Williams and colleagues from Kilifi, Kenya, show that the protection against malaria given by carrying the gene for sickle cell haemoglobin may involve the immune system. Studying a group of children and adults in the Kilifi District of coastal Kenya, they found that this protection increased during childhood up to age 10, and then declined.

It is estimated that cases of malaria causes approximately a million deaths yearly, the overwhelming number of which are young children in sub-Saharan Africa. It has been known for many years that in those areas most afflicted by malaria the gene for sickle cell hemoglobin (HbS) occurs very frequently. The protection against malaria occurs in people who are heterozygote (HbAS), i.e., have one normal and one sickle gene, and previous work has suggested that there is an immune component to this protection.

To discover whether the protection provided by HbAS is innate or varies with age, the authors studied age-specific malaria in a sample of children and adults in the Kilifi District of coastal Kenya. Protection against mild malaria increased up to 60% at age 10, decreasing to 30% in older children.

Research into malaria has yet to yield an effective vaccine but this work may provide some insights for such research. The authors suggest mechanisms by which HbAS could affect immunity, for example, accelerated acquisition of antibodies to altered host proteins expressed on the malaria-infected red cell surface.

###

Citation: Williams TN, Mwangi TW, Roberts DJ, Alexander ND, Weatherall DJ, et al. (2005) An immune basis for malaria protection by the sickle cell trait. PLoS Med 2(5): e128.


'"/>

Source:PLoS


Page: 1

Related biology news :

1. Discovery Promises Simpler Therapy for Sickle Cell Disease
2. Sickle cell disease corrected in human models using stem cell-based gene therapy
3. Key molecule in plant photo-protection identified
4. U.N. mulls the protection of Earths forests
5. UNC plant researchers discover proteins interact to form hair-trigger protection against invaders
6. Vaccine provides 100 percent protection against avian flu virus in animal study
7. Antioxidant selenium offers no heart-disease protection
8. Sun protection for plants
9. Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection
10. Researches discover gene critical for protection against septic-shock-induced death
11. Plant protection from cold decoded
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sickle cell and protection against malaria

(Date:11/4/2014)... published research study examining only marketing directed at ... food restaurants has found that the majority of ... to such marketing tactics. , Authored by Arizona ... the study is the first to examine the ... exterior of fast food restaurants and its relationship ...
(Date:11/4/2014)... Lithuania , Nov. 4, 2014   ... technologies, today announced that the latest version of ... in the Ongoing MINEX evaluation organized ... of fingerprint algorithms using the INCITS 378 fingerprint ... mandatory requirement in public tenders in ...
(Date:11/3/2014)... LOS ANGELES , Nov. 3, 2014 /PRNewswire/ ... California -based life sciences company focused on ... eTNS system for the treatment of neurological ... Institute of Industrial Property has issued a Notice ... The patent application is co-owned by NeuroSigma and ...
Breaking Biology News(10 mins):Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
... pharmaceutical breakthroughs require 21st-century drug discovery tools, such ... high-throughput screening of effective, new compounds. That,s the ... be held Sept. 11 on "Twenty-first Century Bioscience: ... feature a variety of cutting-edge advances in the ...
... researchers today unveiled a prototype model of the first ... could eliminate the need for dialysis. The device, ... as a bioreactor to mimic the metabolic and water-balancing ... a collaborative effort by engineers, biologists and physicians nationwide, ...
... of Neuropsychopharmacology (ECNP) is pleased to announce Moussa B. ... Lifetime Achievement Award in recognition of his innovative and ... neuropsychiatric drug development. The ECNP Lifetime Achievement Award is ... the field of neuropsychopharmacology. The award is accompanied by ...
Cached Biology News:University at Buffalo symposium on in silico methods, high throughput screening 2University at Buffalo symposium on in silico methods, high throughput screening 3UCSF unveils model for implantable artificial kidney to replace dialysis 2UCSF unveils model for implantable artificial kidney to replace dialysis 3Moussa B.H. Youdim wins the 2010 ECNP Lifetime Achievement Award 2
(Date:11/22/2014)... (PRWEB) November 21, 2014 During his ... understood the need to surround himself with great people ... and entrepreneur, his friends often marveled at his extraordinarily ... lived his life and -- even with his death ... the Alzheimer’s disease that would ultimately take his life. ...
(Date:11/22/2014)... RURO, Inc., a leading LIMS, RFID ... version 5.1.4. , RURO’s deployment teams have been ... in RURO’s 8 year history. Many deployments have ... version 5.1.4 is the perfect example – the ... , Limfinity® 5.1.4 release highlights – more than ...
(Date:11/22/2014)... Rapids, MI (PRWEB) November 22, 2014 ... opportunity to simulate the proper management of life-like ... and test lung devices . Grand Rapids-based, Michigan ... plans to donate two of the respiratory simulation ... to $15,000 each. Grand Valley and Muskegon Community ...
(Date:11/21/2014)... -- , Todd Martensen se ... Mariano Rodríguez es elegid vicepresidente senior de desarrollo empresarial y ... marcha para comenzar de forma rápida la comercialización de su ... en Europa   , KLOX Technologies ... siguientes nombramientos: Todd Martensen ha sido ...
Breaking Biology Technology:Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3RURO Announces Limfinity® version 5.1.4 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5
... announced today that it has developed a new SARS specific ... now in the hands of USAMRIID (US Army Medical Research ... Central Public Health Laboratory (UK) and the British Columbia Center ... SARS genome, EraGen went to work immediately to develop a ...
... first-ever Wisconsin Entrepreneurs Conference in Milwaukee last week, it felt ... they were doing and what they planned to do. , ... plan to rid Lake Erie of the dreaded zebra mussel, ... making it the scourge of the entire Great Lakes region. ...
... - The instant Anca Copaescu, then a second-year MBA in ... 2001 G. Steven Burrill Technology Business Plan Competition, she knew ... winning $10,000 - though the money definitely got her attention. ... to fulfill one of her deepest dreams. "Even as a ...
Cached Biology Technology:EraGen Biosciences Ships SARS Diagnostic Test in Record Time 2Entrepreneurial Spirit Infectious in Milwaukee 2Entrepreneurial Spirit Infectious in Milwaukee 3Romanian Student Leverages Burrill Competition to Accomplish Her Dream 2Romanian Student Leverages Burrill Competition to Accomplish Her Dream 3
MAb to HSV-2, gG-2 HSV-2 Glycoprotein G-2...
... immunoblotting the antibody reacts against the reduced ... MMP-2 or MMP-2 bound to TIMP-2. affinity ... Solution in 0.01 M phosphate buffered ... 15 mM sodium azide. synthetic peptide corresponding ...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. Mfr Desig: ...
Biology Products: