Navigation Links
Sickle cell and protection against malaria

In this month's issue of the freely available online journal PLoS Medicine, Dr. Thomas N. Williams and colleagues from Kilifi, Kenya, show that the protection against malaria given by carrying the gene for sickle cell haemoglobin may involve the immune system. Studying a group of children and adults in the Kilifi District of coastal Kenya, they found that this protection increased during childhood up to age 10, and then declined.

It is estimated that cases of malaria causes approximately a million deaths yearly, the overwhelming number of which are young children in sub-Saharan Africa. It has been known for many years that in those areas most afflicted by malaria the gene for sickle cell hemoglobin (HbS) occurs very frequently. The protection against malaria occurs in people who are heterozygote (HbAS), i.e., have one normal and one sickle gene, and previous work has suggested that there is an immune component to this protection.

To discover whether the protection provided by HbAS is innate or varies with age, the authors studied age-specific malaria in a sample of children and adults in the Kilifi District of coastal Kenya. Protection against mild malaria increased up to 60% at age 10, decreasing to 30% in older children.

Research into malaria has yet to yield an effective vaccine but this work may provide some insights for such research. The authors suggest mechanisms by which HbAS could affect immunity, for example, accelerated acquisition of antibodies to altered host proteins expressed on the malaria-infected red cell surface.

###

Citation: Williams TN, Mwangi TW, Roberts DJ, Alexander ND, Weatherall DJ, et al. (2005) An immune basis for malaria protection by the sickle cell trait. PLoS Med 2(5): e128.


'"/>

Source:PLoS


Page: 1

Related biology news :

1. Discovery Promises Simpler Therapy for Sickle Cell Disease
2. Sickle cell disease corrected in human models using stem cell-based gene therapy
3. Key molecule in plant photo-protection identified
4. U.N. mulls the protection of Earths forests
5. UNC plant researchers discover proteins interact to form hair-trigger protection against invaders
6. Vaccine provides 100 percent protection against avian flu virus in animal study
7. Antioxidant selenium offers no heart-disease protection
8. Sun protection for plants
9. Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection
10. Researches discover gene critical for protection against septic-shock-induced death
11. Plant protection from cold decoded
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
Breaking Biology News(10 mins):
(Date:5/21/2017)... ... May 20, 2017 , ... CNSDose ... lengthy trial and error process by finding the right antidepressant faster. CNSDose ... the doctor-patient relationship through a personalized approach to treatment. , A ...
(Date:5/18/2017)... ... May 18, 2017 , ... Dr. Ralph Mobbs of ... Prince Of Wales Private Hospital. The procedure was performed on a 46-year-old male ... conservative treatments prior to undergoing surgery. , The AxioMed viscoelastic disc is a ...
(Date:5/18/2017)... , ... May 17, 2017 , ... NDA Partners Chairman ... and former CEO of Eurofins Advantar Laboratories and President of Pharmaceutical Development Business Unit ... his position at Eurofins and Cardinal Health, he was former Chief Operating Officer at ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... optimization firm for the life sciences and healthcare industries, is honored that ... for Medical Devices conference in Brussels, Belgium. , Crowley played a crucial role ...
Breaking Biology Technology: