Navigation Links
'Shuttling' protein possibly key to resilience of cancer cells

un protein to be produced, attracting more ATF2 and reinforcing the localization of ATF2 in the nucleus.

Because it has been reported that ATF2 overexpression causes the resistance of cancer cells to chemotherapy and radiation, the ATF2 shuttling might play a key role in the ability of cancer cells to resist cancer treatments, and preventing the ATF2 from moving into the cytoplasm might improve the effectiveness of anticancer treatments.

"Ultimately, we are trying to figure out how to make the cancer cells more sensitive to chemotherapy and radiation treatment by keeping the ATF2 in the nucleus," Hu said.

The Purdue researchers tracked ATF2 and other proteins using a fluorescent imaging technique developed by Hu called bimolecular fluorescence complementation. The procedure involves breaking a fluorescent protein into two fragments and then fusing each fragment to different AP-1 proteins, including c-Jun and ATF2. When the proteins later bind to form a heterodimer, the fluorescent-protein fragments are reunited, causing them to glow green when illuminated with a light source. The fluorescence enabled the researchers to pinpoint the location of c-Jun-ATF2 heterodimers and discover the shuttling movements of ATF2. The ATF2 protein also has been found in the cytoplasm of diseased brain cells in Alzheimer's disease and muscle cells in the heart, suggesting the same shuttling mechanism might be involved in those conditions.

"These findings suggest a new avenue to study how ATF2 is implicated in the pathogenesis of these diseases," Hu said.


'"/>

Source:Purdue University


Page: 1 2 3

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Shuttling protein possibly key resilience cancer cells

(Date:4/15/2014)... in nanoparticle form could help reduce side effects by ... years, scientists have developed nanoparticles that deliver one or ... to design particles that can carry any more than ... have devised a new way to build such nanoparticles, ... different drugs. In a paper published in the ...
(Date:4/15/2014)... University of Adelaide research into parasites of cuttlefish, ... parasites, astonishing life cycles, and shown how they ... , Researcher Dr Sarah Catalano has described 10 ... in the kidneys of cephalopods (cuttlefish, squid and ... species to be described from Australian waters. ...
(Date:4/14/2014)... hard pill to swallow, but if you,re over 24 ... terms of your cognitive motor performance, according to a ... Thompson, a psychology doctoral student, associate professor Mark Blair, ... actuarial science doctoral student, deliver the news in a ... In one of the first social science experiments to ...
Breaking Biology News(10 mins):Targeting cancer with a triple threat 2Targeting cancer with a triple threat 3Bizarre parasite may provide cuttlefish clues 2Study says we're over the hill at 24 2
... first detailed molecular images of a piece of the spike-shaped ... and initiate the first stages of infection. The structure, which ... scientists learn new details about how the virus infects cells. ... points that can be exploited by novel antiviral drugs or ...
... the Albert Einstein College of Medicine have discovered a ... may soon be able to resist the effects of ... disease-causing microbes, including Shigella and E. coli, are rapidly ... was led by Dr. John S. Blanchard, the Dan ...
... genetics of barley could lead to improved varieties of ... whisky and beer. Scientists funded in part by the ... a new programme to uncover key genes that control ... research, being carried out at the Scottish Crop Research ...
Cached Biology News:Learning how SARS spikes its quarry 2Learning how SARS spikes its quarry 3Einstein researchers identify new way that bacteria develop resistance to antibiotics 2Whisky fans can drink to crop research 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... 2008 R&D 100 Awards Now Online, ROCKAWAY, N.J., ... the 8th Annual Innovator of the Year and 43rd ... exemplify the,ideals of R&D in academia, industry, and nationally ... with ten finalists,-- five scientists and five innovators -- ...
... TOLEDO is pleased to announce that Dr. Francis Stoessel, ... Institute (SWISSI), will be the Keynote Speaker in the ... , ... Columbia, MD ...
... ALBANY, Ore., Sept. 30 Synthetech, Inc. (OTC,Bulletin ... Frederic,Farkas as Director of Manufacturing effective on October ... consulting services to Synthetech. Dr. Farkas,has over 13 ... API,manufacturing from previous positions in manufacturing and supply ...
Cached Biology Technology:2008 R&D Innovator of the Year & Scientist of the Year Finalists Announced 2Synthetech Announces New Director of Manufacturing 2
... Combining linear motor and ballscrew ... pre-engineered Cartesian solutions that include ... management, and motors., , ... Pass through high-flex cabling for ...
UGT1A6 (D-20)...
... T Squareds patented high efficiency dynamic valve ... With the most compact, lightweight package in ... use in portable air and gas applications., ... high efficiency. , Includes DC Motor. ...
... designed for moving loads quickly and accurately. ... output while limiting overall size. The P5S-P ... ball bearings guided on two rails., ... provide energy absorption and controlled deceleration , ...
Biology Products: