Navigation Links
'Shuttling' protein possibly key to resilience of cancer cells

un protein to be produced, attracting more ATF2 and reinforcing the localization of ATF2 in the nucleus.

Because it has been reported that ATF2 overexpression causes the resistance of cancer cells to chemotherapy and radiation, the ATF2 shuttling might play a key role in the ability of cancer cells to resist cancer treatments, and preventing the ATF2 from moving into the cytoplasm might improve the effectiveness of anticancer treatments.

"Ultimately, we are trying to figure out how to make the cancer cells more sensitive to chemotherapy and radiation treatment by keeping the ATF2 in the nucleus," Hu said.

The Purdue researchers tracked ATF2 and other proteins using a fluorescent imaging technique developed by Hu called bimolecular fluorescence complementation. The procedure involves breaking a fluorescent protein into two fragments and then fusing each fragment to different AP-1 proteins, including c-Jun and ATF2. When the proteins later bind to form a heterodimer, the fluorescent-protein fragments are reunited, causing them to glow green when illuminated with a light source. The fluorescence enabled the researchers to pinpoint the location of c-Jun-ATF2 heterodimers and discover the shuttling movements of ATF2. The ATF2 protein also has been found in the cytoplasm of diseased brain cells in Alzheimer's disease and muscle cells in the heart, suggesting the same shuttling mechanism might be involved in those conditions.

"These findings suggest a new avenue to study how ATF2 is implicated in the pathogenesis of these diseases," Hu said.


'"/>

Source:Purdue University


Page: 1 2 3

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:12/4/2008)...cience will be published by Springer as of Januar...ty of Fisheries Science, previously published by W...he publication of basic and applied research artic...fisheries science. , Published in English six t... and review articles covering a wide array of topi...
(Date:12/3/2008)...ones, deputy executive director of the Internation...utlook 2008" Dec. 9 at Rice University,s Baker Ins...uch questions as: Is the world facing a supply cru...hat type of post-Kyoto policy framework might stab..., and what impact might such a policy framework ha...
(Date:12/3/2008)...s number one at the box office this week. The most... of the body, filmed by scientists using ground-br...ralia, scientists at Sydney,s Centenary Institute ...parasite and followed the infection as it begins t...ang Weninger, head of the Immune Imaging program a...
(Date:12/3/2008)...Ore. December 3, 2008. The first 5-year forest inv...s is now available to the public: Oregon,s Forest ...nd Analysis Report. , Here are some key findings...t 30 million acres; about half of Oregon,s total l...ing converted to other uses particularly near urba...
Breaking Biology News(10 mins):'World Energy Outlook' to be presented at Rice University Dec. 9 2Scientists film inner workings of the immune system 2Forest inventories in Oregon include more than trees 2Forest inventories in Oregon include more than trees 3Insulin Resistance Tied to Peripheral Artery Disease 21986 1Insulin Resistance Tied to Peripheral Artery Disease 21986 2Lou Gehrigs protein found throughout brain suggesting effects beyond motor neurons 21983 1Lou Gehrigs protein found throughout brain suggesting effects beyond motor neurons 21983 2AHIP Statement on American Medical Association 28AMA 29 Claims Processing Report 21978 1AHIP Statement on American Medical Association 28AMA 29 Claims Processing Report 21978 2VNUS Medical Technologies to Present at William Blair 26 Companys 28th Annual Growth Stock Conference 21973 1
...itute researchers have identified a molecular mech...me, how consuming foods rich in saturated fats and... cholesterol and triglycerides and increases one,s...the Jan. 28 issue of Cell, scientists led by Bruce...of saturated and trans fats are set in motion by a...
...risk breast cancer treated with radical mastectomy...ion therapy leads to better survival outcomes with...ar follow-up of a randomized trial, which appears ...onal Cancer Institute. , The British Columbia ran...termine the effect on survival of the addition of ...
... of a recent U.S. study, investigators in Japan fo... and a potentially life-threatening form of high b... The Journal of Infectious Diseases, now available...e not able to detect human herpesvirus 8 (HHV-8), ...ungs of 22 patients with primary or other forms of...
... in the envelope (Env) protein of a mouse breast t...s into cancer cells, according to a study by Katz ...xperimental Medicine. The ability of this motif to...al infection may be an important and previously un...quence in question is usually found in immune cell...
Other Biology News:Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats 2Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats 3Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down 2Association of herpesvirus with lung disorder questioned 2
(Date:12/4/2008)...TLANTA and LACHEN, Switzerland, Dec. 4 /PRNewswire... announced that Dennis D. Curtin has been,selecte...ited States. Curtin,had been Octapharma,s U.S. le...ident of Life Therapeutics, Inc. , The larg...Octapharma,recently acquired Life Therapeutics, t...
(Date:12/4/2008)...EW YORK, Dec. 4 NeoStem,...ng the pre-disease collection,processing and lon...cal need,today announced that it has reached a m...the opening of the first ever collection center fo...ublic for future medical need in New York,City an...
(Date:12/4/2008)...UBLIN, December 4 Azur Pharma Limi...into a definitive agreement with BioSante,Pharmac...uire U.S. rights to,Elestrin(TM). Elestrin is a f...indicated for the treatment of moderate to severe ...strin was approved by the U.S. Food and Drug,Admi...
(Date:12/4/2008)...URHAM, N.C., Dec. 4 Parion Science...Sciences (Nasdaq: GILD ), has initiated a Phase ...to evaluate the safety and,tolerability of the in...rease,airway hydration for the treatment of pulmo...is an epithelial sodium channel (ENaC) blocker dis...
Breaking Biology Technology:Octapharma Names Dennis D. Curtin To Lead U.S. Plasma Operations 2NeoStem's New York City Adult Stem Cell Collection Center Has Opened and Begun Collections 2NeoStem's New York City Adult Stem Cell Collection Center Has Opened and Begun Collections 3NeoStem's New York City Adult Stem Cell Collection Center Has Opened and Begun Collections 4Azur Pharma Ltd. Enters Into Definitive Agreement With BioSante Pharmaceuticals Inc [nasdaq: BPAX], to Acquire U.S. Rights to Elestrin (TM) 2Parion Sciences Announces Initiation of Phase I Clinical Trial to Evaluate Safety and Tolerability of GS9411 2Parion Sciences Announces Initiation of Phase I Clinical Trial to Evaluate Safety and Tolerability of GS9411 3
..., , , , , , This method pro..., g lgt10 DNA per 450 l of supernatant proce...nction with other LambdaDNA purification methods. ...stock of suitable plating bacteria in L-broth plus...t, 0.5% NaCl, 1 mM MgSO4, pH 7.5) overnight , ...
..., , , , Katherine A. Borkovich PhD...vich PhD, University of Texas-Houston Medical Cent...olecular Genetics, Houston, Texas. , Kimbe...Systems Application , Lab, Westbury, New Yo...TION: , The diverse reproductive capabil...
..., , , , Kurt Lucas, Eppendorf AG ,...nificance of cell fusion , Electrical cel...innovative , methods in modern biology, s..., the cloning of mammals, and vaccination a...ly induced cell fusion via polyethylene glycol (PE...
... , , , Note: Genomic DNA is fragile.... by mechanical forces. Use suitable large-bore ...nomic DNA. Do not vortex solutions containing geno... Nuclei from blood , Caution: Wear s...fety , measures when working with human b...
Other Biology Technology:Lambda DNA Extraction Protocol 2Efficient Transfection of Neurospora Crassa 2Efficient Transfection of Neurospora Crassa 3Efficient Transfection of Neurospora Crassa 4Efficient Transfection of Neurospora Crassa 5Principles and applications of electrical cell fusion 2Principles and applications of electrical cell fusion 3Principles and applications of electrical cell fusion 4Principles and applications of electrical cell fusion 5Genomic DNA Isolation Protocol(1,2,3) 2Genomic DNA Isolation Protocol(1,2,3) 3Genomic DNA Isolation Protocol(1,2,3) 4
...ERAsafe KS convince with an optimum product, perso...new frameless slanted window does not obscure the ... makes it easy to work in a relaxed posture. The l...mm ensures ease of handling. ,The eye-level displ...
Fluoroskan Ascent FL is equipped with both fluorometric and luminometric measurement technologies that complement the long list of advanced features of Fluoroskan Ascent and Luminoskan Ascent. Fluoro
Thermo's orbital shaker stands both present the shaker at a more ergonomic height, and help protect user safety. Purpose-built from welded tubular steel, these heavy-duty accessories are designed to
Polyribonucleotides (RNA polymers) are prepared by the catalytic action of the enzyme, polynucleotide phosphorylase, isolated at Midland, and the appropriate, ribonucleoside diphosphate as substrate.
Biology Products: