Navigation Links
Shorter colds, milder flu may follow from newly revealed immune mechanism

Enlisted to help fight viral infections, immune cells called macrophages consume virus-infected cells to stop the spread of the disease in the body. Now researchers at Washington University School of Medicine in St. Louis have uncovered how macrophages keep from succumbing to the infection themselves. Boosting this mechanism may be a way to speed recovery from respiratory infections.

The researchers found that a specific protein produced in the course of respiratory viral infections can serve to protect macrophages from an untimely death. Their report will appear in an upcoming issue of Nature Medicine and is available on October 9 at the journal's website.

"If the macrophages were to die, the infection would spread further," says senior author Michael J. Holtzman, M.D., the Selma and Herman Seldin Professor of Medicine and director of pulmonary and critical care medicine. "So the macrophages use a protein called CCL5 to ensure that the infection process can be stopped before it goes any further."

Holtzman thinks the information about the role of CCL5 may lead to new methods to hasten recovery from respiratory viral inflections like influenza or the common cold, which at present have no pharmacological cure.

CCL5's role was discovered while Holtzman's group was testing mice that had respiratory infections. They found that the sick mice produced massive amounts of CCL5--about a hundred times more than they produced when healthy.

"CCL5 was just off the chart compared to the other 30,000 mouse genes," Holtzman says. "Then the challenge was to figure out why CCL5 gene expression should be so far above everything else."

They found that mice lacking the gene to make CCL5 died much more frequently from respiratory virus infection than normal mice. Examining lung tissues from these CCL5-deficient mice, the researchers saw that macrophages--which would ordinarily enter the airway, clean up virus-infected cells and then leave--
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Geoscientists follow arsenic from chicken feed to streambeds
2. Study: Paramedics save more lives when they dont follow the rules
3. Evolution follows few of the possible paths to antibiotic resistance
4. Use of amino acid supplement following a heart attack provides no benefit, may be harmful
5. Cell death following blood reflow injury tracked to natural toxin
6. Long-term cancer risk follows stem cell transplant recipients
7. High levels of blindness in southern Sudan following years of war
8. History-hunting geneticists can still follow familiar trail
9. PNAS study reveals why organs fail following massive trauma
10. Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
11. Palaus coral reefs show differential habitat recovery following the 1998 bleaching event
Post Your Comments:
(Date:1/22/2015)... , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading source ... launch of its new website design. "When we ... infancy", says Peter O,Neill , founder and CEO of ... industry needs involvement from the key players on a very ...
(Date:1/22/2015)... OXFORD, Conn. , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: ... growing mobile commerce market, reports on the recent success of the Wocket™ ... Wocket smart wallet was named as one of the ... of the "5 Best Products Launched At CES So Far" by Newseveryday.com ...
(Date:1/22/2015)... NEW YORK , Jan. 22, 2015   EyeLock, Inc. ... announced it has appointed Steve Gerber to the ... Gerber will be responsible for leading development of mobile platforms ... 25 years of success and innovation in the semiconductor industry ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... 2008 TGen has spun off its third ... source for oncologists. The for-profit, privately held ... sources, including genetic-based medical discoveries by the non-profit, ... Online aims to provide oncologists with the knowledge ...
... bioMETRX, Inc., (OTC,Bulletin Board: BMRX), the ... announced that Frank Santamorena, a world,renowned security ... Directors,effective October 21, 2008., Frank Santamorena ... high level,security expertise. Frank is a consultant ...
... deadlines loom for manufacturers of chemicals for products ranging ... Philadelphia will bring together scientists, cosmetics formulators, and policy ... of the Cosmetics Directive, a series of deadlines for ... massive undertaking to identify potential hazards from thousands of ...
Cached Biology News:TGen spin-off MedTrust Online enables cancer doctors to quickly obtain best-available information 2bioMETRX, Inc. Welcomes Residential and Commercial Security Expert to Board of Directors 2bioMETRX, Inc. Welcomes Residential and Commercial Security Expert to Board of Directors 3Spotlight on cosmetic ingredients conference 2
(Date:1/22/2015)... The laboratory information management systems market ... number of technological advancements due to factors such as ... to integrate healthcare systems, and increasing government support for ... integration. Key players in the market focus on technological ...
(Date:1/22/2015)... MA (PRWEB) January 22, 2015 zFlo ... is pleased to announce an exciting product from a new ... motion analysis solutions over the past 15 years, with offerings ... Most recently, their 3D IMU system (inertial measurement unit), iSen, ...
(Date:1/22/2015)... 2015 Diagenode, Inc., a leading ... Bioruptor® and complete solutions for epigenetics research, recently ... alleviating the need for manual processing. The new ... ChIP of histones or transcription factors and a ...
(Date:1/22/2015)... 2015   GenoSpace , a precision medicine software company that ... broad use of genomic, imaging and other biomedical data in ... Michelle Munson , CEO of Aspera, an IBM Company, to ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to ...
Breaking Biology Technology:Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 43D Motion Capture Just Got Easy 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2GenoSpace Expands Board with Appointment of Michelle Munson 2
... , , ... MindWorks, Inc. (CMI) announced today the release of Sevocity 08. ... new Conceptual MindWorks customers. Sevocity 08 is pre-market, conditionally ... (CCHIT(R)) and meets the Commission,s ambulatory electronic health record (EHR) ...
... LAKE MARY, Fla., Aug. 28 Renewable fuels ... that on August 26, 2009, it received a letter from ... the Company,s stockholders equity as reported in the Company,s Quarterly ... 2009, the Company is no longer in compliance with the ...
... Aug. 27 Champions Biotechnology, Inc. (OTC Bulletin Board: CSBR), ... and tumor specific data to enhance the value of oncology ... ended April 30, 2009. Full details of the Company,s financial ... www.championsbiotechnology.com. , , For the fiscal year ...
Cached Biology Technology:Sevocity EHR 08 Released With ARRA (Stimulus) Commitment 2New Generation Biofuels Receives NASDAQ Notice of Noncompliance with Continued Listing Requirements 2Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 2Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 3Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 4Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 5
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
...
PURA Immunogen: PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Mouse monoclonal [3F8 ] to smooth muscle Myosin heavy chain I ( Abpromise for all tested applications). entrezGeneID: 4629 SwissProtID: P35749...
Biology Products: