Navigation Links
Shorter colds, milder flu may follow from newly revealed immune mechanism

Enlisted to help fight viral infections, immune cells called macrophages consume virus-infected cells to stop the spread of the disease in the body. Now researchers at Washington University School of Medicine in St. Louis have uncovered how macrophages keep from succumbing to the infection themselves. Boosting this mechanism may be a way to speed recovery from respiratory infections.

The researchers found that a specific protein produced in the course of respiratory viral infections can serve to protect macrophages from an untimely death. Their report will appear in an upcoming issue of Nature Medicine and is available on October 9 at the journal's website.

"If the macrophages were to die, the infection would spread further," says senior author Michael J. Holtzman, M.D., the Selma and Herman Seldin Professor of Medicine and director of pulmonary and critical care medicine. "So the macrophages use a protein called CCL5 to ensure that the infection process can be stopped before it goes any further."

Holtzman thinks the information about the role of CCL5 may lead to new methods to hasten recovery from respiratory viral inflections like influenza or the common cold, which at present have no pharmacological cure.

CCL5's role was discovered while Holtzman's group was testing mice that had respiratory infections. They found that the sick mice produced massive amounts of CCL5--about a hundred times more than they produced when healthy.

"CCL5 was just off the chart compared to the other 30,000 mouse genes," Holtzman says. "Then the challenge was to figure out why CCL5 gene expression should be so far above everything else."

They found that mice lacking the gene to make CCL5 died much more frequently from respiratory virus infection than normal mice. Examining lung tissues from these CCL5-deficient mice, the researchers saw that macrophages--which would ordinarily enter the airway, clean up virus-infected cells and then leave--
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Geoscientists follow arsenic from chicken feed to streambeds
2. Study: Paramedics save more lives when they dont follow the rules
3. Evolution follows few of the possible paths to antibiotic resistance
4. Use of amino acid supplement following a heart attack provides no benefit, may be harmful
5. Cell death following blood reflow injury tracked to natural toxin
6. Long-term cancer risk follows stem cell transplant recipients
7. High levels of blindness in southern Sudan following years of war
8. History-hunting geneticists can still follow familiar trail
9. PNAS study reveals why organs fail following massive trauma
10. Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
11. Palaus coral reefs show differential habitat recovery following the 1998 bleaching event
Post Your Comments:
(Date:7/20/2015)... DENVER , July 20, 2015  Acuity ... Mobility Report: The Convergence of Commerce and Privacy" ... billion mobile biometric apps will be downloaded to ... users. The mobile biometrics market is projected to ... app revenue during the seven-year forecast period.    ...
(Date:7/9/2015)... , July 9, 2015  Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 30, 2015 after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
(Date:7/9/2015)... JOSE, Calif. , July 9, 2015 ... the leading developer of human interface solutions, ... technology, the industry,s first fully hardware encapsulated ... Match-in-Sensor secure authentication technology is literally off ... storage and biometric matching within the fingerprint ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... LEDs to light UT arena . . . ... the University of Tennessee,s Thompson-Boling Arena will become the ... smaller, brighter and up to 85 percent more efficient ... fixtures developed by Oak Ridge-based LED North America incorporate ...
... peninsula of 11,500 km2 within the Arabian Peninsula. Both ... last decades, thus putting a strong pressure on native ... development has triggered a variety of studies of its ... confirmed the occurrence of 21 lizard species, two of ...
... bone marrow cells to deliver potentially curative gene therapy ... syndrome an often fatal condition that causes organ ... Children,s Hospital Medical Center and the National Institute of ... for treating the disease the week of Feb. 3-7 ...
Cached Biology News:Story tips from the Department of Energy's Oak Ridge National Laboratory, February 2014 2Story tips from the Department of Energy's Oak Ridge National Laboratory, February 2014 3Where do lizards in Qatar live? First distribution maps for the state 2Mouse study shows gene therapy may be possible cure for Hurler syndrome 2
(Date:7/24/2015)... Frederick, MD (PRWEB) , ... ... ... software is a class-leading frozen sample management solution, indispensable to any modern ... web-based application that has a user-friendly interface. Users know precisely where a ...
(Date:7/23/2015)... ... July 23, 2015 , ... One hundred years ago ... 1915 National Model Aeroplane Competition, with hopes of winning the Henry S. Villard Trophy. ... centennial. , Participants will have the opportunity to build a Free Flight fantasy club ...
(Date:7/23/2015)... 23, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC ... Pharmaceutical Holding Company Limited (Biohaven), are pleased to ... Drug (IND) Application with the U.S. Food and ... BHV-0223. Portage holds 54% equity interest in Biohaven, ... glutamate modulating agent and Biohaven has entered into ...
(Date:7/23/2015)... MIAMI (PRWEB) , ... July 23, 2015 , ... ... stem cell research in Santiago, Chile. The symposium will feature some of the ... a full day of high-level scientific discussion for medical professionals in general practice. , ...
Breaking Biology Technology:RURO, Inc. Partners with Integrated Systems Engineering to Provide Comprehensive LIMS Software to Biobanks 2RURO, Inc. Partners with Integrated Systems Engineering to Provide Comprehensive LIMS Software to Biobanks 3RURO, Inc. Partners with Integrated Systems Engineering to Provide Comprehensive LIMS Software to Biobanks 4Academy of Model Aeronautics to Start Online Fantasy Flight Competition 2Portage's Biohaven Announces IND Filing for BHV-0223 for Phase 1 Clinical Testing 2Portage's Biohaven Announces IND Filing for BHV-0223 for Phase 1 Clinical Testing 3Portage's Biohaven Announces IND Filing for BHV-0223 for Phase 1 Clinical Testing 4Global Stem Cells Group Announces Plans to Hold International Symposium on Stem Cells and Regenerative Medicine in Santiago, Chile Sept. 3-4, 2015 2Global Stem Cells Group Announces Plans to Hold International Symposium on Stem Cells and Regenerative Medicine in Santiago, Chile Sept. 3-4, 2015 3
... Polymer nano-films and nano-composites are used in a ... sports equipment to automotive and aerospace applications. Thermal ... these applications, but the growing trend to use ... In recent years an atomic force microscope-based ...
... N.J., Jan. 12, 2012 NeoStem,s cell therapy ... Inc. company (NYSE Amex: NBS ) ... whereby PCT will provide contract manufacturing and regulatory ... – PTM, which will be an injectable suspension ...
... the way pavement, softened by a hot sun, will ... with wondrous propertiesslows down an object sliding across its ... slippery, say theorists at the National Institute of Standards ... the material,s friction. "I don,t think anyone expects ...
Cached Biology Technology:Magnetic actuation enables nanoscale thermal analysis 2Islet Sciences, Inc. Selects NeoStem's Manufacturing Subsidiary Progenitor Cell Therapy for Product Manufacturing 2Islet Sciences, Inc. Selects NeoStem's Manufacturing Subsidiary Progenitor Cell Therapy for Product Manufacturing 3Islet Sciences, Inc. Selects NeoStem's Manufacturing Subsidiary Progenitor Cell Therapy for Product Manufacturing 4Slippery when stacked: NIST theorists quantify the friction of graphene 2
... Kit measures adenosine triphosphate (ATP) ... a dynamic range. Based on ... measures ATP in bacterial, plant ... concentration range of 10-11 to ...
... of refrigerated cold traps offers a choice ... volatility/aqueous solvents or high volatility solvents. Ideal ... concentrators/centrifugal evaporators. Also used for maintaining vapor-free ... used in electron microscopes. Can be used ...
... Trap is specifically designed for efficient ... as DMSO and DMF in the ... refrigeration system set at -5 o ... DMSO, while completely eliminating the risk ...
Black 96 Well Plate EB, RE Bottom...
Biology Products: