Navigation Links
'Sharp' older brains are not the same as younger brains

Researchers working with rats have found the first solid evidence that still "sharp" older brains store and encode memories differently than younger brains.

This discovery is reported by a Johns Hopkins team in the issue of Nature Neuroscience released online Nov. 13. Should it prove to apply as well to human brains, it could lead eventually to the development of new preventive treatments and therapies based on what healthy older brains are doing, rather than on the less relevant, younger brain model, according to study co-author Michela Gallagher, chair of the Department of Psychological and Brain Sciences at Johns Hopkins' Zanvyl Krieger School of Arts and Sciences.

"We found that aged rats with preserved cognitive abilities are not biologically equivalent to young rats in some of the basic machinery that neurons use to encode and store information in the brain," said Gallagher, who collaborated with Alfredo Kirkwood and Sun Seek Min of Johns Hopkins' Krieger Mind/Brain Institute and Hey-Kyoung Lee, now of the University of Maryland College Park. Lee was a research associate at the Mind/Brain Institute when the research was done.

The Gallagher-Kirkwood team compared the brains of 6-month-old rats with those of 2-year-old (considered "aged") rodents that had performed in the "young" range on various learning tasks. The aged rats' brains also were compared with those of older rats which showed declines in their abilities to learn new things. The researchers were looking at a key set of nerve cell connections that store information by modifying the strength of chemical communications at their synapses. (Synapses are the tiny gaps between nerve cells, where chemicals released by one cell act upon another.) Synaptic communication is the way brains register and preserve information to form memories.

The team found that while the older rats with compromised cognition had brains that had lost the ability to adjust the force of those syna
'"/>

Source:Johns Hopkins University


Page: 1 2

Related biology news :

1. Color perception is not in the eye of the beholder: Its in the brain
2. Amazon trees much older than assumed, raising questions on global climate impact of region
3. Alleged 40,000-year-old human footprints in Mexico much, much older than thought
4. Confidence in memory performance helps older adults remember
5. High estrogen levels associated with dementia in older men
6. Fertility hope as study shows eggs survive in older ovaries
7. 76 percent of workers older than 60 years of age are overweight or obese
8. 1/3 of sexually active older adults with HIV/AIDs has unprotected sex
9. Sleep quantity affects morning testosterone levels in older men
10. Birds brains reveal source of songs
11. Supercomputers to focus brains on AIDS dilemma
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sharp older brains are not the same younger brains

(Date:8/29/2014)... number of connections in transcription factor networks (TFNs) to ... study published in PLOS Computational Biology in ... contributes to a network,s resilience against mutations. , ... of TFN models has a greater effect on robustness ... assortativity," said Dov A. Pechenick, PhD, lead author and ...
(Date:8/29/2014)... of marine phytoplankton, such as the prolific bloomer ... (thiamine), researchers have discovered. The finding contradicts the common ... eukaryotic microbes depend on scarce supplies of thiamine in ... way to think about the ocean," says CIFAR Senior ... ISME Journal paper with CIFAR fellows John ...
(Date:8/29/2014)... Tibetan plateau -- the largest topographic anomaly above sea ... profound effect on climate and its reflection of continental ... , Katharine Huntington and colleagues employ a cutting-edge geochemical ... fossil snail shells to investigate the uplift history of ... range widely on the timing of surface uplift of ...
Breaking Biology News(10 mins):Assortativity signatures of transcription factor networks contribute to robustness 2Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... eye, and intestinal tract infections, and, like other viruses, ... order to produce proteins and their own viral spawn. ... from Chinese and Australian universities has found a way ... damage the viruses in the laboratory environment, before they ...
... -- Parkinson,s disease is marked by the abnormal accumulation ... in the substantia nigra region of the brain. A ... NACP-Rep1 has been implicated as a risk factor for ... variants of NACP-Rep1 and its interaction with the microtubule-associated ...
... having an effect on Earth,s ecosystems but it,s not just ... we are causing. Now you can add an over-abundance of ... question is how large of an impact will be felt. ... Science (Dec. 16, 2011), Arizona State University researcher ...
Cached Biology News:Plasma treatment zaps viruses before they can attack cells 2Genetic factors can predict the progression of Parkinson's disease 2Researchers assess effects of a world awash in nitrogen 2
(Date:8/29/2014)... Inc. (NYSE MKT: PFNX), a clinical-stage biotechnology company ... to manufacture proteins including biosimilar therapeutics, today provided ... the second quarter ended June 30, 2014. ... public offering, we have the capital to continue ... our proprietary protein expression platform," stated Bertrand C. ...
(Date:8/29/2014)... are based on electrons, but one of the most ... i.e. circuits based on light (photons) instead of electrons. ... a stream of single photons and control their direction. ... attempts to achieve this control, but now scientists at ... steady stream of photons emitted one at a time ...
(Date:8/29/2014)... New York (PRWEB) August 29, 2014 ... valued at $5.6 billion in 2019. It is ... from 2013 to 2019, and was valued at ... report published by Transparency Market Research. , For ... visit: http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research report, ...
(Date:8/29/2014)... According to a new market report published by ... was valued at USD 3,754.6 million in 2012 and is ... a CAGR of 5.9% from 2013 to 2019. , Nearly ... afflicted by bone and joint disorders, and this number is ... and will continue to increase the demand for orthobiologics. Other ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Breakthrough in light sources for new quantum technology 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
... GlaxoSmithKline Will Also Be Vying to Capture, Shares of ... ... from Decision Resources, WALTHAM, Mass., Nov. 19 Decision ... pharmaceutical and,healthcare issues, finds that the most promising antibiotics in ...
... 18 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,(ASX: PXS, Nasdaq: PXSL) today ... Purchase Plan which closed on 9 November 2007. ... purchase up to $5,000 worth of,shares each at ... the,recent placement. A total of 2,496 shareholders ...
... BERKELEY HEIGHTS, N.J., Nov. 16 Genta,Incorporated (Nasdaq: ... letter from the NASDAQ Stock Market stating that the,Company,s ... Global,Market because the Company does not comply with the ... as set forth in,Marketplace Rule 4450(a)(3). The Company intends ...
Cached Biology Technology:Drugs from Johnson & Johnson/Basilea and Forest Are the Most Promising Antibiotics in the Community-Acquired Pneumonia Pipeline 2Pharmaxis Closes Share Purchase Plan 2Genta Receives Notice of Non-Compliance with Listing Requirement for NASDAQ Global Market 2Genta Receives Notice of Non-Compliance with Listing Requirement for NASDAQ Global Market 3
Lyophilized. Purity: ≥90% by electrophoresis. Reconstitute in 0.3% NaCl. Prepared from serum that has been shown by certified tests to be negative for HBsAg and for HIV and HCV antibodies. ...
p230 trans Golgi Purified Anti-Human clone 15, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
... and highly photostable FluoSpheres microspheres have ... variety of applications requiring probes that ... protein- and other macromolecule-labeled microspheres have ... to bind to non-target surfaces in ...
DNA Polymerase I Large (Klenow) Fragment is a DNA polymerase that lacks the 5'Cut Site3' exodeoxyribonuclease activity of intact DNA Polymerase I but it contains the 3'Cut Site5' exodeoxyribonuclease...
Biology Products: