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Several minute intermediate stage in virus-cell fusion discovered; opportunity for drug development

tored in the lab, allowing for an exquisite level of control of the whole process," said Young. "This allows us to do things that are not possible with other systems."

The next stage is for researchers to confirm that other viruses such as HIV also have an intermediate step. Preliminary data from the Melikyan laboratory indicate that this may be the case for HIV. "We already know that the entire HIV fusion sequence is very slow, sometimes taking several hours," said Melikyan. "It is not inconceivable that it, too, has an intermediate step that lasts several minutes, giving us an adequate time window for drug action."


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Source:Salk Institute


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