Navigation Links
Secrets to antibody's success against West Nile Virus surprise scientists

Insights may advance vaccines for related viruses including dengue fever. A monoclonal antibody that can effectively treat mice infected with West Nile virus has an intriguing secret: Contrary to scientists' expectations, it does not block the virus's ability to attach to host cells. Instead, the antibody somehow stops the infectious process at a later point.

"This was a complete surprise to us, but it gives us some very useful insights," says senior author Daved Fremont, Ph.D., associate professor of pathology & immunology and of biochemistry & molecular biophysics at Washington University School of Medicine in St. Louis. "Based on what we've learned, we are now developing therapeutic antibodies for related viruses that also are effective at stopping the process of infection after the virus attaches to host cells."

Detailed study of how the antibody physically binds to the virus has provided intriguing clues to how it may block infection. Scientists found evidence suggesting that the antibody prevents the virus from rearranging the protein envelope that surrounds its genetic material after it enters a host cell.

To reproduce, a virus must alter its envelope in order to inject its genetic material inside the cell. After that injection, the virus tricks the host cell into making more copies of the genetic material that can then be assembled into new viral particles or virions and sent out to infect other host cells and reproduce. But with the viral reproduction process blocked by the antibody, scientists suspect that the host cell eventually destroys the virion.

Fremont and colleagues, who publish their results in the Sept. 29 issue of Nature, hope to design a new diagnostic system that can determine whether vaccines for West Nile and related viruses undergoing clinical trials stimulate production of antibodies that stop infections at a similar point.

In 2004, West Nile virus, which is a mosquito-borne flaviviru
'"/>

Source:Washington University School of Medicine


Page: 1 2 3 4

Related biology news :

1. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
2. Secrets of the deep may hold key to life on other planets
3. Secrets of the sea yield stronger artificial bone
4. Buckyballs boost antibodys chemotherapy payload
5. A single sugar found responsible for an antibodys ability to treat inflammation
6. New, automated tool successfully classifies and relates proteins in unprecedented way
7. Biomarkers isolated from saliva successfully predict oral and breast cancer
8. Secret of smallpoxs success may lead to bioterror cure
9. UN successfully tests green pesticide against locusts
10. Stem cell therapy successfully treats heart attack in animals
11. Mad cow proteins successfully detected in blood
Post Your Comments:
(Date:12/22/2014)... Conn. , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market, ... Apollo Robbins for the 2015 International CES debut ... Apollo Robbins will be at the NXT-ID booth January ...
(Date:12/19/2014)... 2014  23andMe, Inc., the leading personal genetics company, today announced ... genetic ancestry of individuals from across the United ... than four hundred years ago, the United States ... from different continents. This study illuminates how American history and ...
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... paper being presented in two American Physiological Society ... team demonstrated "for the first time that mitochondria ... mitochondria may mechanically regulate nuclear function." , The ... years, reported that it recently "found a very ...
... There's no doubt that laughter feels good, but is ... do about it? , In a paper being presented ... 2006, Lee S. Berk of Loma Linda University, reports ... but just the anticipation of the "mirthful laughter" involved ...
... different plant species are not only more productive, they ... climate extremes, pests and disease over long periods of ... issue of Nature, are the culmination of 12 years ... Ecology at the University of Minnesota, to explore the ...
Cached Biology News:First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown 2First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown 3Just the expectation of a mirthful laughter experience boosts endorphins 27 percent, HGH 87 percent 2Just the expectation of a mirthful laughter experience boosts endorphins 27 percent, HGH 87 percent 3Biodiversity key to sustainable biofuel according to University of Minn. researcher's findings 2
(Date:1/22/2015)... January 22, 2015 GEA Niro Soavi ... top laboratory homogenizer, the PandaPLUS 2000, which is ideal ... , and cell disruption . This compact laboratory ... fruit juices, liquid food, food additives and ingredients as ...
(Date:1/22/2015)... Rootstown, OH (PRWEB) January 22, 2015 Crystal ... announced today that it has received AOAC-PTM Certifications for the ... O111, O121, and O145; collectively referred to as STEC or ... at 1 colony forming unit (cfu) per 325 g of ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Selexis SA, ... mammalian Research Cell Banks (RCBs) used for drug discovery ... Cell Banks will include Next-Generation Sequencing (NGS) ... architecture de-risks biologic manufacturing by ensuring the integrity of ...
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2
... MADISON, WI- The UW-Madison Business Schools Weinert Applied Ventures in ... development in Wisconsin. , ,According to Larry Cox, Director ... at the UW-Madison School of Business, entrepreneurial culture lags behind ... of great technology. We have wonderful research thats going on ...
... - GE Medical Systems, a unit of General Electric ... the U.S. Food and Drug Administration to begin marketing ... system. The Signa EXCITE 3.0T combines the increased speed ... the breadth of imaging capabilities found on premium 1.5 ...
... Americas, Inc., a division of GE Industrial Systems, ... (MSI), a Green Bay manufacturing software development company. ... Manufacturing Execution Systems (MES) technology for the manufacturing ... sciences as well as for pulp and paper ...
Cached Biology Technology:WAVE of the Future? 2WAVE of the Future? 3GE Medical Systems Receives FDA Clearance for New MRI System 2Green Bay Software Company Purchased by GE 2
... personal-sized Thermal Cycler is the ideal instrument for ... range of PCR applications. Get Applied ... Save lab space without sacrificing results. ... Industry-Standard PCR Technology You Can Afford ...
... upgraded micro 10 represents a major advance ... of the benefits of large robotic liquid ... benchtop dispenser. Dispensing accurate volumes ranging from ... 10 has unique advantages not yet found ...
This free-standing laminar flow hood provides a horizontal flow of HEPA-filtered air to create a clean processing area. Air return slots along the front and side edges of the work area enhance system...
... Motic's B3 series of microscopes offer all ... required for laboratory work. Equipped with Koehler ... Contrast (ASC) objectives. The B3 is the ... Siedentopf binocular tube eliminates the need for ...
Biology Products: