Navigation Links
Secrets to antibody's success against West Nile Virus surprise scientists

Insights may advance vaccines for related viruses including dengue fever. A monoclonal antibody that can effectively treat mice infected with West Nile virus has an intriguing secret: Contrary to scientists' expectations, it does not block the virus's ability to attach to host cells. Instead, the antibody somehow stops the infectious process at a later point.

"This was a complete surprise to us, but it gives us some very useful insights," says senior author Daved Fremont, Ph.D., associate professor of pathology & immunology and of biochemistry & molecular biophysics at Washington University School of Medicine in St. Louis. "Based on what we've learned, we are now developing therapeutic antibodies for related viruses that also are effective at stopping the process of infection after the virus attaches to host cells."

Detailed study of how the antibody physically binds to the virus has provided intriguing clues to how it may block infection. Scientists found evidence suggesting that the antibody prevents the virus from rearranging the protein envelope that surrounds its genetic material after it enters a host cell.

To reproduce, a virus must alter its envelope in order to inject its genetic material inside the cell. After that injection, the virus tricks the host cell into making more copies of the genetic material that can then be assembled into new viral particles or virions and sent out to infect other host cells and reproduce. But with the viral reproduction process blocked by the antibody, scientists suspect that the host cell eventually destroys the virion.

Fremont and colleagues, who publish their results in the Sept. 29 issue of Nature, hope to design a new diagnostic system that can determine whether vaccines for West Nile and related viruses undergoing clinical trials stimulate production of antibodies that stop infections at a similar point.

In 2004, West Nile virus, which is a mosquito-borne flaviviru
'"/>

Source:Washington University School of Medicine


Page: 1 2 3 4

Related biology news :

1. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
2. Secrets of the deep may hold key to life on other planets
3. Secrets of the sea yield stronger artificial bone
4. Buckyballs boost antibodys chemotherapy payload
5. A single sugar found responsible for an antibodys ability to treat inflammation
6. New, automated tool successfully classifies and relates proteins in unprecedented way
7. Biomarkers isolated from saliva successfully predict oral and breast cancer
8. Secret of smallpoxs success may lead to bioterror cure
9. UN successfully tests green pesticide against locusts
10. Stem cell therapy successfully treats heart attack in animals
11. Mad cow proteins successfully detected in blood
Post Your Comments:
(Date:7/28/2014)... explorer Roald Amundsen reached the South Pole in 1911, ... long before any human. , Using data from 16 ... Antarctic continent, including the South Pole, a group led ... in Reno, Nevada, created the most accurate and precise ... continent. The new record, described in an article published ...
(Date:7/28/2014)... a circulatory problem of the legs called peripheral vascular ... surgery in serious cases. This disease can lead to ... , At The University of Texas Health Science Center ... preventative treatment in a mouse model of the disease ... Their proof-of-concept study appears in the journal Cell ...
(Date:7/28/2014)... -- Fifteen years ago, MIT professor John Essigmann and colleagues ... an HIV drug. They thought if they could induce the ... and eventually die out a strategy that our immune ... such a drug, which caused HIV to mutate at an ... virus from patients in a small clinical trial reported in ...
Breaking Biology News(10 mins):Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2Forced mutations doom HIV 2Forced mutations doom HIV 3Forced mutations doom HIV 4
... since Darwin first published The Origin of the Species, ... common ancestor of all living species. Paleontological, biochemical, and ... tree. Now a team of researchers, led by ... at Buffalo and including area high school students, has ...
... largest drought in 50 years has severely damaged much of ... Minnesota,s 2012 corn crop. While an extreme, this summer,s condition ... to use limited resources like water in an effective and ... the University of Minnesota, seeks to address these challenges through ...
... forest reserves in a new study are ineffective, according ... by William Laurance, research associate at the Smithsonian Tropical ... and more than 200 co-authors., "Biodiversity is declining ... Republic of Congo, Xishuangbanna in southern China, and Northern ...
Cached Biology News:Researchers dig through the gene bank to uncover the roots of the evolutionary tree 2U of M researcher's 'Darwinian Agriculture' explains how evolution can improve agriculture 2U of M researcher's 'Darwinian Agriculture' explains how evolution can improve agriculture 3
(Date:7/29/2014)... Tenn. (PRWEB) July 29, 2014 ... in biomass feedstock supply innovation and supply chain ... proprietary feedstock management systems, Energy Grange™ and Supply ... of R&D and in-the-field testing aimed at consolidating ... offering benefits to landowners, farmers and feedstock end ...
(Date:7/29/2014)... G-CON Manufacturing Inc., the standard in ... a new leadership appointment designed to drive the company’s ... , Maik Jornitz, Chief Operating Officer of G-Con ... with leading the pioneering company through its next phase ... of development and look forward to providing our next ...
(Date:7/29/2014)... 2014 White papers by Clinovo ... based eClinical technologies, have been published by leading pharmaceutical ... a long line of white papers by Clinovo to ... Science Leader, Pharmaceutical Online, and OpenHealthNews. , At the ... by CTO Marc Desgrousilliers, 'The Five Essentials of ...
(Date:7/28/2014)... VA (PRWEB) July 28, 2014 The ... nonprofit authority on the use of health IT to ... Health Plan Identifier (HPID) Workgroup has developed ... a Health Plan and Payer?” The HPID Workgroup, a ... closely with the Centers for Medicare and Medicaid Services ...
Breaking Biology Technology:Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2
... May 11 N30 Pharma (N30), a biopharmaceutical company focused on the discovery ... oxide, announced today that it has completed a $10 million financing and ... , Joining the Company,s ... , , ...
... /PRNewswire-Asia-FirstCall/ -- Yongye International, Inc.,(Nasdaq: YONG ), ("Yongye" or the "Company") a ... China , today announced that it will conduct a conference call at ... for the quarter ended March 31,2010 . , ... To participate in the live conference call, ...
... China , May 11 /PRNewswire-Asia-FirstCall/ -- 3SBio Inc.,(Nasdaq: SSRX ... on researching, developing, manufacturing and marketing,biopharmaceutical products, today announced that it will ... on May 16, 2010 ,at 8:00pm (Eastern). , ... Following ...
Cached Biology Technology:Yongye International Announces Conference Call to Discuss First Quarter Fiscal Year 2010 Results 23SBio Inc. To Report 2010 First Quarter Unaudited Financial Results on May 16, 2010 2
...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
... Virgin, optically clear polystyrene with frosted ... coordinates for cell counting. 100% integrity ... a new product number, created to ... showing no availability yet, please order ...
... clear polystyrene with frosted labeling surfaces, ... cell counting. 100% integrity tested. Linkage: ... product number, created to easily match ... availability yet, please order under the ...
Biology Products: