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Secret of worm's poison pill box protein could produce new natural insecticide

omplex" which makes the XptA1 300 times more toxic to the caterpillars than it would be by itself. As well as helping collect together the three proteins and attach them to the insect’s gut the researchers think that the box shape of the XptA1 protein possibly also helps protect the poison complex from the acid attack they would face from the high pH values in the insect gut. The researchers also discovered that, while XptA1 was highly selective in that it bound to the cabbage white butterfly caterpillar, there were variants of this family of toxic proteins (such as XptA2) that targeted other insects.

Dr Sarah Lee from the University of Warwick said: "This research gives us crucial new insights into a family of naturally occurring proteins that are toxic to a number of insect pests. They offer an alternative to current commercial protein based insect toxins have been in use for 40 years and are now starting to meet some resistance. This potential new family of protein based insecticides would overcome such resistance as they operate in an entirely different way"
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Source:University of Warwick


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