Navigation Links
Second messenger NAADP shows fast, dose-related impact on satiety cycle

lization in pancreatic acinar cells. Despite the intensive study into the physiological role of NAADP in Ca2+ signaling in pancreatic anicar cells, direct demonstration of changes in NAADP levels in response to agonist-stimulations has been lacking, Yamasaki said.

"We found that application of cholecystokinin to isolated populations of pancreatic acinar cells caused NAAPD level to increase as much as 6-fold in only 5 to 10 seconds," Yamasaki said. The cholecystokinin-A receptor, expressed predominantly in pancreatic acinar cells, has two binding sites, one of high and one of low affinity.

"Unequivocal evidence that NAADP is a crucial messenger"

"Intriguingly, the plot of NAADP level versus cholecystokinin concentration was best fit with a two-site model, suggesting that both the high- and low-affinity sites were linked to NAADP production," Yamasaki said. In contrast to the hormone cholecystokinin, the neurotransmitter acetylcholine failed to affect NAADP level, even when applied at supramaximal concentrations in terms of physiological relevance and which saturate the calcium amplitude and spiking frequency.

In conclusion, Yamasaki said, "Our data in this experiment provides the first direct evidence that cholecystokinin elicits a rapid, dose-dependent and selective increase in NAADP, and thus unequivocal evidence that NAADP is a crucial messenger employed by cholecystokinin."

Yamasaki noted that NAADP has "a short history compared to other traditional intracellular messengers and many aspects of this molecule remain under investigation. However the potential of this new messenger as a therapeutic target should not be underestimated," she added.


'"/>

Source:American Physiological Society


Page: 1 2 3

Related biology news :

1. Second opinion yields treatment changes for half of patients
2. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
3. Killing the messenger RNA -- But which one?
4. Notorious cancer gene may work by destroying messenger
5. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
6. “Nano-scissors?laser shows precise surgical capability
7. Clam embryo study shows pollutant mixture adversely affects nerve cell development
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. Study shows nanoshells ideal as chemical nanosensors
10. Gene vaccine for Alzheimers disease shows promising results
11. Flocking together: Study shows how animal groups find their way
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Second messenger NAADP shows fast dose related impact satiety cycle

(Date:4/18/2014)... For the past 20 years, researchers have published soil ... findings have suggested that soil organic carbon can be ... systems to no-till systems. However, there is a growing ... corn and soybean rotations without cover crops, small grains, ... stocks at the published rates. , "Some studies have ...
(Date:4/18/2014)... Asteroid and comet impacts can cause widespread ecological havoc, ... global scales. But new research from Brown University shows ... life at the time of an impact. , A ... found fragments of leaves and preserved organic compounds lodged ... Argentina. The material could provide a snapshot of environmental ...
(Date:4/17/2014)... A drug under clinical trials to treat tuberculosis ... drugs that act against various bacteria, fungal infections and ... University of Illinois chemists and collaborators. , Led by ... determined the different ways the drug SQ109 attacks the ... target other pathogens from yeast to malaria and ...
Breaking Biology News(10 mins):Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3Multitarget TB drug could treat other diseases, evade resistance 2
... women who are obese may be more than twice as ... female teens who are not obese, according to a study ... Neurology , the medical journal of the American Academy of ... Health Study and Nurses, Health Study II who were 25 ...
... the hopeful news is that pediatric survival rates have ... enable survival often cause infertility. Boys ... an opportunity to preserve their fertility: before undergoing cancer ... in sperm banks. Younger boys, however, do not produce ...
... has completed a first draft of the cassava (Manihot esculenta) ... the pace of research on this subsistence crop and addressing ... the world. Cassava is a root crop that serves ... people each day. Although it has many properties that make ...
Cached Biology News:Teenage obesity linked to increased risk of MS 2For young boys with cancer, testicular tissue banking may be option to preserve fertility 2For young boys with cancer, testicular tissue banking may be option to preserve fertility 3Researchers complete draft genome sequence for cassava 2Researchers complete draft genome sequence for cassava 3Researchers complete draft genome sequence for cassava 4
(Date:1/15/2014)... NY (PRWEB) January 15, 2014 The Microcompetition ... a major disease. One of these latent viruses is the ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory ... theory, a study found that RA patients have high concentrations ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched ... tinnitus. Patients listen to sound therapy that is tailor-made ... weeks to months, their tinnitus volume decreases. , AudioNotch has ... and Notched White Noise. Now, AudioNotch is pleased to announce ...
(Date:1/14/2014)... 14, 2014 Histogen, Inc., a regenerative ... cells grown under simulated embryonic conditions, today announced that ... Suneva Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s ... This agreement is an amendment to the existing license ...
(Date:1/14/2014)... Texas , Jan. 14, 2014 The ... and research medicinal plants and therapeutic derivatives thereof ... health professionals, and researchers about the challenges of ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
... on Advanced WiMAX Broadband Wireless Technology, Will, Provide Free Internet ... ... Sapir Community College, PETACH TIKVA, Israel, January 8 ... in Israel, today announced that it has joined,with Israel,s Ministry ...
... 7 Quest Diagnostics,Incorporated (NYSE: DGX ), ... services, announced that it is scheduled to speak,at ... January 8,2008, at the Westin St. Francis in ... to begin at 11:00 a.m. Eastern Time., ...
... NxStage Medical, Inc.,(Nasdaq: NXTM ), a leading ... has signed a five-year agreement with DaVita, Inc.,(NYSE: ... dialysis centers with,MasterGuard and ButtonHole safety needle sets, ... essential products used to access patients,blood during the ...
Cached Biology Technology:Israel's Ministry of Communications, 012 Smile.Communications, Intel and Alvarion Join in Launching WiMAX Initiative for Sderot, a City in the Western Negev 2Israel's Ministry of Communications, 012 Smile.Communications, Intel and Alvarion Join in Launching WiMAX Initiative for Sderot, a City in the Western Negev 3Israel's Ministry of Communications, 012 Smile.Communications, Intel and Alvarion Join in Launching WiMAX Initiative for Sderot, a City in the Western Negev 4Israel's Ministry of Communications, 012 Smile.Communications, Intel and Alvarion Join in Launching WiMAX Initiative for Sderot, a City in the Western Negev 5Quest Diagnostics to Speak at the 26th Annual JPMorgan Healthcare Conference 2NxStage Medical Announces Needle Supply Agreement with DaVita 2