Navigation Links
Second messenger NAADP shows fast, dose-related impact on satiety cycle

One traditional approach to pharmaceutical design uses so-called "first messengers" ?hormones, other natural facilitators or synthetic products ?to initiate various cellular cascades for the desired physiological effect. To date, despite concerted efforts at all levels of research, this approach has failed to develop a truly successful obesity drug to address this major global health problem.

Enter a recently discovered and already controversial natural molecule called nicotinic acid adenine dinucleotide phosphate (NAADP), which is active in cells from plants to humans. NAADP is thought to be a so-called "second messenger," because it works from inside cells, rather than externally. However its mode operation remains unknown ?and controversial in several aspects.

Results of a new study "establishes NAADP as a new second messenger, and the study of this novel molecule has potential to extend its clinical significance, possibly as a candidate for treating obesity," according to the lead author, Michiko Yamasaki at the Department of Pharmacology, University of Oxford, United Kingdom.

Yamasaki is presenting the research at the 35th Congress of the International Union of Physiological Sciences in San Diego, March 31 - April 5, 2005.

*Paper presentation and "controversy" appearance: "Rapid, selective and dose-dependent elevation of the second messenger NAADP," 12:30 p.m.-3 p.m. Tuesday April 5, Physiology 932.3/board #A438. On view 7:30 a.m. - 4 p.m.

In addition, Ms. Yamasaki was chosen to participate in a special "controversy" session #654 of the Calcium Signaling Track on April 4 in room 29C of the Convention Center beginning at 10:30; her presentation is scheduled for 11:45 a.m.

The team working on the study was comprised of Michiko Yamasaki, Grant Churchill and Antony Galione at the Department of Pharmacology, University of Oxford; Sandip Patel at University College London; and Jose M. Cancela at CNRS, Laboratoire de Neur
'"/>

Source:American Physiological Society


Page: 1 2 3

Related biology news :

1. Second opinion yields treatment changes for half of patients
2. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
3. Killing the messenger RNA -- But which one?
4. Notorious cancer gene may work by destroying messenger
5. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
6. “Nano-scissors?laser shows precise surgical capability
7. Clam embryo study shows pollutant mixture adversely affects nerve cell development
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. Study shows nanoshells ideal as chemical nanosensors
10. Gene vaccine for Alzheimers disease shows promising results
11. Flocking together: Study shows how animal groups find their way
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Second messenger NAADP shows fast dose related impact satiety cycle

(Date:6/30/2015)... -- Genisphere announced Tom Bliss ... develop Genisphere,s therapeutics capabilities and portfolio. Mr. Bliss comes ... of the last 25 years in leadership positions at ... & Johnson. Tom started his career in Investment Banking, ... He graduated from Dartmouth College with a BA in ...
(Date:6/25/2015)... , June 25, 2015  TAKE Solutions Ltd., a ... by the United States Patent and Trademark Office (USPTO) ... process leverages TAKE Solutions, Clinical Accelerators to reduce the ... (when compared to standardization without the accelerators), thus reducing ... At the heart of the patented ...
(Date:6/24/2015)... Biometry authentication provider KeyLemon today announced ... one face in. Logo - ... in, entering the expanding biometric authentication market in ... answer to the password problem. With advanced face ... KeyLemon, one face in allows users to securely ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3TAKE Solutions Awarded Patent By USPTO 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2
... Institute lung cancer research team reports that lung cancer ... model, offering a new avenue for investigating immunotherapy treatment ... C. Morris, MD, and his colleagues report their findings ... One , a peer-reviewed online publication that features original ...
... UC Irvine biologists have discovered that fats within cells ... revealing a previously unknown type of immune system response ... UCI professor of developmental & cell biology, and colleagues ... fruit flies, and it could herald a new approach ...
... This press release is available in Spanish ... 13 November 2012Today, the Nuevo Len state ministry of ... Cooperation (CEC), launched a revamped air quality information management ... CEC initiative, developed in coordination with Canadian, Mexican and ...
Cached Biology News:Stem cell finding could advance immunotherapy for lung cancer 2New type of bacterial protection found within cells 2State of Nuevo León first to benefit from improved nationwide air quality information system 2
(Date:7/1/2015)... Ariz. , July 1, 2015 Isagenix ... it has earned three Gold, three Silver, and three ... Awards gala held in Chicago ... as the premier business awards program in the U.S. ... recognizes our company,s strength in developing leaders, cultivating talent, ...
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today that company ... Philadelphia, PA. , The presentation took place on Tuesday, June 16 and ... the development of APX3330 for the treatment of pancreatic cancer. A copy of ...
(Date:6/30/2015)... , July 1, 2015 R-Japan Co.,Ltd. obtained ... the Safety of Regenerative Medicine from the Ministry of Health, ... June 29, 2015. The fact that R- ... facility through the auditing from Pharmaceuticals and Medical Devices Agency ... application, allows it to provide stem cell manufacturing service to ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... a webinar to provide advanced scientific research into new classes of Nanoscale Graphene-based ... energy. Touted as 'the wonder material of the 21st Century' by the ...
Breaking Biology Technology:Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4
... had to reboot my washing machine. Not just turning it ... pulled the power plug from the wall, waited a few ... the outlet. Flashing lights, a trill of beeps, and voil: ... me to thinking just how complicated ordinary machines have become, ...
... CLAIRE, Wis. -- Small Tree Communications , a ... a focus on Mac OS X, has announced a ... , ,Link aggregation, an implementation of the IEEE ... computer into one virtual interface, combining the individual ports' ...
... Teresa Esser will be joining WTN as a weekly ... interviews, book reviews and opinion articles related to entrepreneurship ... the psychology of entrepreneurship and the lifestyle issues associated ... his previous book The Millionaire Next Door , ...
Cached Biology Technology:Have you rebooted? 2Have you rebooted? 3Have you rebooted? 4Unique profiles, anecdotes increase Millionaire Womens net worth 2Unique profiles, anecdotes increase Millionaire Womens net worth 3Unique profiles, anecdotes increase Millionaire Womens net worth 4
V beta 5 Purified Anti-Human clone MH3-2, Isotype Mouse IgG 2a , kappa, 0.1 mg Consult technical datasheet for details....
...
... PROTEAN II xi 2-D system runs both gel dimensions ... tube gels can be separated in a single run ... cooling core in much the same manner as the ... the second-dimension slab gels may be cast in the ...
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: