Navigation Links
Sea skate experiment sheds light on human cell transport

Along with Mark Musch, a longtime University of Chicago collaborator, Goldstein conducted an experiment with the red blood cells of skates to understand how these skinny, graceful fish can swim from salt water to fresh water. For humans, such a drastic environmental change would prompt an equally drastic physiological change: Our cells would take in too much water, diluting blood and other body fluids and rapidly causing death. So how do skates do it?

Goldstein and Musch learned how cellular channels, or gates, spring into action when skate red blood cells become engorged with water. Vesicles, or tiny fluid-filled sacs, carry these gates up to the cell membrane. The vesicles are inserted into the membrane and a chemical process known as phosphorylation takes place. This activates the gates, which open to release excess water along with salts and other organic material.

The researchers made their discovery by using a plant-based substance to block an enzyme that causes phosphorylation. The result: The gates wouldn't open. These findings are published in the current issue of the American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, along with an accompanying editorial.

Goldstein said the results are important for a few reasons.

Because skate red blood cells closely resemble cells in the human kidney, the findings shed light on how these organs cope with excess water. But Goldstein and Musch also believe the mechanisms that trigger this cellular "release valve" are universal.

"We think that vesicle insertion, coupled with phosphorylation, is a broad mechanism for getting substances in and out of cells," Goldstein said. "The idea that we can apply this knowledge to other cells and other animals ?including humans ?is what makes the findings exciting."

In type 1 diabetes, cells lose their ability to transport glucose. Goldstein and Musch say their findings could explain the problem. People with t ype 1 diabetes don't produce insulin. Without that hormone, vesicles aren't inserted into cell membranes ?and glucose can't be moved between cells.

And when channels are blocked, damaged cells can't die. This cell "suicide" is one of the body's defenses against cancer. "There is a possible relationship between operation of these channels and the uncontrolled multiplication of cancer cells," Goldstein said. "If so, this research points up an important area for future research."


Source:Brown University

Related biology news :

1. Worlds largest rainforest drying experiment completes first phase
2. Wyoming cloud seeding experiment begins this month
3. Melanoma vaccine strategy shows promise in laboratory experiments
4. Failed experiment yields a biocontrol agent that doesnt trigger antibiotic resistance
5. Novel experiment documents evolution of genome in near-real time
6. Bacteria collection sheds light on urinary tract infections
7. Bacterial genome sheds light on synthesizing cancer-fighting compounds
8. Newly discovered genetic disease sheds light on bodys water balance
9. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
10. Gene discovery sheds light on causes of rare disease, cancer
11. Skull study sheds light on dinosaur diversity
Post Your Comments:

(Date:11/10/2015)... , Nov. 10, 2015  In this ... the basis of product, type, application, disease ... in this report are consumables, services, software. ... are safety biomarkers, efficacy biomarkers, and validation ... report are diagnostics development, drug discovery and ...
(Date:11/4/2015)... , November 4, 2015 ... new market report published by Transparency Market Research "Home Security ... Trends and Forecast 2015 - 2022", the global home security ... 30.3 bn by 2022. The market is estimated to ... period from 2015 to 2022. Rising security needs among ...
(Date:10/29/2015)... -- Daon, a global leader in mobile biometric authentication ... version of its IdentityX Platform , IdentityX v4.0. ... have already installed IdentityX v4.0 and are seeing ... UAF certified server component as an option and ... These customers include some of the largest and most ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... PUNE, India , November 24, 2015 ... to a new market research report "Oligonucleotide Synthesis Market ... Equipment), Application (PCR, Gene Synthesis, Diagnostic, DNA, RNAi), End-User ... to 2020", published by MarketsandMarkets, the market is expected ... 1,078.1 Million in 2015, at a CAGR of 10.1% ...
(Date:11/24/2015)... SHPG ) announced today that Jeff Poulton , Chief ... Annual Healthcare Conference in New York City , ... p.m. GMT). --> SHPG ) announced today that ... Jaffray 27 th Annual Healthcare Conference in New ... 8:30 a.m. EST (1:30 p.m. GMT). --> Shire plc ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris ... today that the remaining 11,000 post-share consolidation (or ... Warrants (the "Series B Warrants") subject to the ... on November 23, 2015, which will result in ... giving effect to the issuance of such shares, ...
(Date:11/24/2015)... Switzerland (PRWEB) , ... November 24, 2015 , ... InSphero ... organotypic 3D cell culture models, has promoted Melanie Aregger to serve as Chief Operating ... Ms. Aregger served on the management team and was promoted to Head ...
Breaking Biology Technology: