Navigation Links
Sea skate experiment sheds light on human cell transport

Along with Mark Musch, a longtime University of Chicago collaborator, Goldstein conducted an experiment with the red blood cells of skates to understand how these skinny, graceful fish can swim from salt water to fresh water. For humans, such a drastic environmental change would prompt an equally drastic physiological change: Our cells would take in too much water, diluting blood and other body fluids and rapidly causing death. So how do skates do it?

Goldstein and Musch learned how cellular channels, or gates, spring into action when skate red blood cells become engorged with water. Vesicles, or tiny fluid-filled sacs, carry these gates up to the cell membrane. The vesicles are inserted into the membrane and a chemical process known as phosphorylation takes place. This activates the gates, which open to release excess water along with salts and other organic material.

The researchers made their discovery by using a plant-based substance to block an enzyme that causes phosphorylation. The result: The gates wouldn't open. These findings are published in the current issue of the American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, along with an accompanying editorial.

Goldstein said the results are important for a few reasons.

Because skate red blood cells closely resemble cells in the human kidney, the findings shed light on how these organs cope with excess water. But Goldstein and Musch also believe the mechanisms that trigger this cellular "release valve" are universal.

"We think that vesicle insertion, coupled with phosphorylation, is a broad mechanism for getting substances in and out of cells," Goldstein said. "The idea that we can apply this knowledge to other cells and other animals ?including humans ?is what makes the findings exciting."

In type 1 diabetes, cells lose their ability to transport glucose. Goldstein and Musch say their findings could explain the problem. People with t ype 1 diabetes don't produce insulin. Without that hormone, vesicles aren't inserted into cell membranes ?and glucose can't be moved between cells.

And when channels are blocked, damaged cells can't die. This cell "suicide" is one of the body's defenses against cancer. "There is a possible relationship between operation of these channels and the uncontrolled multiplication of cancer cells," Goldstein said. "If so, this research points up an important area for future research."


'"/>

Source:Brown University


Related biology news :

1. Worlds largest rainforest drying experiment completes first phase
2. Wyoming cloud seeding experiment begins this month
3. Melanoma vaccine strategy shows promise in laboratory experiments
4. Failed experiment yields a biocontrol agent that doesnt trigger antibiotic resistance
5. Novel experiment documents evolution of genome in near-real time
6. Bacteria collection sheds light on urinary tract infections
7. Bacterial genome sheds light on synthesizing cancer-fighting compounds
8. Newly discovered genetic disease sheds light on bodys water balance
9. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
10. Gene discovery sheds light on causes of rare disease, cancer
11. Skull study sheds light on dinosaur diversity
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2016)... , Dec. 5, 2016  The Office ... today published "Can CT Scans Enhance or Replace ... the potential of supporting or replacing forensic autopsies ... CT scan. In response to recommendations ... is exploring using CT scans as a potential ...
(Date:12/2/2016)... , Dec. 1, 2016   SoftServe , ... BioLock , an electrocardiogram (ECG) biosensor analysis ... a key IoT asset. The smart system ensures ... vehicle,s steering wheel and mobile devices to easily ... As vehicle technology advances, so too ...
(Date:11/30/2016)... , Nov. 30, 2016  higi SH ... new partnership initiative targeting national brands, industry thought-leaders ... reward their respective audiences for taking steps to ... its inception in 2012, higi has built the ... impacting over 38 million people who have conducted ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... -- According to a new market research report "Oligonucleotide ... Equipment), Application (Research, PCR, Gene, DNA, NGS, Diagnostic, RNAI), End user ... global market is expected to reach USD 2.20 Billion by 2021 ... during the forecast period. Continue Reading ... ...
(Date:12/8/2016)... 2016 This report analyzes the worldwide markets for ... (Humic, Amino, & Fulvic), Extract Based, and Others. The report ... Ornamental & Turf, Row Crops, and Others. The report provides ... , Japan , Europe ... , and Rest of World. Annual estimates and forecasts ...
(Date:12/8/2016)... -- OncoSec Medical Incorporated ("OncoSec") (NASDAQ: ONCS ... today announced financial results for the fiscal first ... on our commitment to address an unmet medical ... pleased with the early clinical response data presented ... focused on advancing our lead program – ImmunoPulse® ...
(Date:12/8/2016)... AskLinkerReports.com has published a report on ... Industry 2016 Market Research Report. From a basic outline of ... are all covered in the report. This report projects investment ... of the Amyloglucosidase industry. ... , , Complete ...
Breaking Biology Technology: