Navigation Links
Sea coral's trick helps scientists tag proteins

rchers have demonstrated that it can switch shades at the body temperature of birds and mammals, which are popular research models. Its usefulness is further enhanced by the fact that it stays red for long-term protein tracking, Sergey Lukyanov explained.

Dendra is the latest addition to the growing family of photoactivatable fluorescent proteins (PAFPs), innovative imaging tools first made possible by Douglas Prasher, who isolated the gene for green fluorescent protein (GFP) from a species of bioluminescent jellyfish in 1992, and Martin Chalfie, who first used GFP for labeling in 1994, said Marc Zimmer, a computational chemist at Connecticut College and author of Glowing Genes: A Revolution in Biotechnology (2005). Since then, HHMI investigator Roger Tsien has developed a veritable rainbow of refined high-performance GFP mutants.

A major breakthrough in fluorescent protein applications came when Sergey Lukyanov first found GFP-like proteins in corals, Zimmer said. Before Lukyanov, no one had looked for GFP-like proteins in corals because they do not glow in the dark like fireflies and jellyfish. The corals' native green and red fluorescent proteins give off light only when stimulated by higher intensity light. Lukyanov's findings resulted in the discovery of many new GFP-like proteins in non-bioluminescent and sometimes even non-fluorescent marine organisms, Zimmer said.

Meanwhile, Sergey Lukyanov and other researchers had discovered that certain wavelengths of light could cause striking spectral changes in some proteins, which could convert from dark to light or change colors. Later, the Russian scientist and his colleagues discovered that the GFP-like protein they isolated from Dendronephthya had this capacity to change color, but it was too big to be useful for many research applications.

So the Lukyanovs and colleagues set out to create a smaller and more versatile version of their fluorescent protein. They systematically mutat
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Old drug, new tricks: Prospects for slashing the impact of malaria
2. Dangerous tricksters: Some bacterie use immune cells to reproduce
3. Researchers use trickery to create immune response against melanoma
4. New finding points way to foiling anthraxs tricks
5. A wolf in sheeps clothing: Plague bacteria reveal one of their virulence tricks
6. An AIDS-related virus tricks cells to become tumors, new Penn study finds
7. Scientists perform tricky operation
8. Yale biologists trick viruses into extinction
9. Toxoplasmosis infection trick revealed by scientists
10. Jumping gene helps explain immune systems abilities
11. Protein helps regulate the genes of embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sea coral trick helps scientists tag proteins

(Date:12/5/2014)... VIEW, Calif. , Dec. 4, 2014 /PRNewswire/ ... safety has boosted investments in new testing and ... has also given rise to a range of ... by the requirements of Generation Y, which is ... technologies. As a result, product development strategies of ...
(Date:11/21/2014)... According to a new market ... RFID, Access Control, Intrusion Detection, Parking Management, Under Vehicle ... Service Geography - Global Forecasts to 2020", published by ... be around $25 Billion in 2014 and is expected ... CAGR of 8.69%. Browse 116 market data ...
(Date:11/18/2014)... 2014  The Secure Identity & Biometrics Association ... announce the formation of The Airport Entry and ... Identity and Biometric Entry and Exit Solutions Framework ... support from BORDERPOL, the international non-profit organization that ... expertise regarding border security, traveler and migration systems. ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... Health announced today it has launched an innovative clinical ... determine the causes of idiopathic human diseases -- those serious, ... are unresponsive to standard treatments. The use of whole ... treating rare medical cases. Whole genome sequencing provides information ...
... research team has discovered that a pervasive human RNA ... process that contributes to obesity and type II diabetes. ... gene was the major gene associated with obesity and ... and cellular functioning remained unknown. Now, a team ...
... device to help victims of spinal cord injury is ... PhD, associate professor, in the department of biomedical engineering ... his findings to develop micro-electrical stimulators for individuals with ... now in its third year of support from a ...
Cached Biology News:Scripps launches whole genome sequencing study to find root causes of idiopathic diseases 2Scripps launches whole genome sequencing study to find root causes of idiopathic diseases 3New research links common RNA modification to obesity 2New research links common RNA modification to obesity 3NJIT researcher testing micro-electronic stimulators for spinal cord injuries 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... trouble with most anti-cancer therapies is that they are ... cancer cells. As a result, patients experience side effects ... of developing secondary cancers later in life. Researchers at ... deliver cancer drugs directly to tumors, increasing their effectiveness ...
... cylinders composed of one-atom-thick carbon lattices, have gained fame as ... group of researchers from the University of Michigan is taking ... low refractive index of low-density aligned nanotubes, to demonstrate a ... a flat, black sheet. The refractive index of ...
... by the Air Force Office of Scientific Research (AFOSR) was chosen ... Drs Ali Aliev, Yuri Gartstein and Ray Baughman, ... producing what is technically referred to as the "mirage effect from ... popular press have termed it: an ,invisibility cloak,." ...
Cached Biology Technology:Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment 2
... The lyophilization stabilizer is designed ... process and for long-term storage. ... toxic ingredients. It is a ... pH 7.2, and is superior to ...
... coating stabilizer is designed for stabilizing ... and antibodies for immunoassay development. ... during the coating and drying process ... It can also works as a ...
... Clinical is Tecans open platform for clinical ... safety and performance in the clinical diagnostic ... by flexible barcode reading and sample traceability ... the system complies with the IVD-Directive* established ...
... the smallest thermal cyclers on the market, which ... 0.5ml (20 samples) or 0.2ml microtube (25 samples) ... and cooling rate of 3.6C/sec and 2.0C/sec respectively ... Fast track programming with new quick dial facility ...
Biology Products: