Navigation Links
Sea Ice May Be on Increase in the Antarctic

A protein that extends lifespan in yeast, worms, and flies keeps blood sugar under control in mice, reports a new study in the August Cell Metabolism. The findings suggest therapeutic interventions for the prevention and treatment of metabolic disorders, such as type 2 diabetes, which frequently arise with age, the researchers said.

The team found that mice with an excess of the protein Sirt1 in cells of the pancreas have improved glucose tolerance and enhanced insulin secretion in response to glucose. Glucose is the principal circulating sugar in the blood and the major energy source of the body.

"Mice with an increased amount of Sirt1 show a better response to high blood glucose levels that regularly occur after eating sweets, such as cookies or cakes," said Shin-ichiro Imai of Washington University School of Medicine. "The mice respond fast to high glucose by raising insulin levels, clearing the blood of the circulating sugar."

"Under normal feeding conditions, when glucose levels are lower, the mice with elevated Sirt1 appear normal," Imai added. "This is good news, suggesting that therapies designed to manipulate the amount of Sirt1 might improve insulin response in those with type 2 diabetes without causing other problems."

Pancreatic b cells have a highly coordinated mechanism that senses rises in blood glucose and converts that information into signals that increase the secretion of insulin, Imai explained. Insulin produced by the pancreas allows cells to take up glucose from the bloodstream and burn it for energy. A failure to make or respond to insulin in people with diabetes causes blood sugar levels to rise.

The researchers found that Sirt1 is present in pancreas cells that secrete insulin hormone. Mice genetically modified to have an excess of Sirt1 in b cells of the pancreas had improved glucose tolerance and enhanced insulin secretion in response to glucose.

The altered mice maintained their improved b ce ll function with age, they reported. Further analyses found that Sirt1 regulates genes involved in insulin secretion by b cells.

"Together, these results establish that an increase dosage of Sirt1 has beneficial effects on mammalian physiology," Imai said. "Our findings also provide new insight into the physiological and molecular functions of Sirt1 in glucose metabolism and suggest therapeutic interventions for the prevention and treatment of diabetes and other age-associated metabolic disorders."


'"/>

Source:NASA


Related biology news :

1. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
2. Increased risk of osteoporosis associated with gene that one in five people have
3. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
4. Morphine for Chest Pain Increases Death Risk
5. Use of Antibiotics for Acne May Increase Risk of Common Illness
6. Increased sensitivity to nerve signals keeps diabetes at bay
7. Increase in carbon dioxide emissions accelerating
8. Increase in drug development for killer diseases is not enough
9. UTSA researchers examine effects of global warming on Antarctic
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/9/2019)... ... May 09, 2019 , ... Akadeum ... of products based on its microbubble technology. Unlike magnetic-based products, microbubbles use buoyancy ... surface. Feedback from customers who participated in an early access program has been ...
(Date:5/8/2019)... Conn. and TORONTO (PRWEB) , ... May 08, ... ... growth recapitalization of Axiom Real-Time Metrics (“Axiom”), a premier provider of unified eClinical ... II and III clinical trials and observational studies. Axiom is a leading e-clinical ...
(Date:5/2/2019)... PHILADELPHIA (PRWEB) , ... April 30, 2019 , ... ... & Nadel LLP is pleased to announce that Gunes Bender, Ph.D., a ... firm’s life sciences practice group. In his new role, Bender provides technical support ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... Calif. (PRWEB) , ... April 09, 2019 , ... Sonny ... his left front limb for approximately two months. After a series of diagnostics, ... flexor tendon. Sonny’s owner, Alison, researched the injury and found that VetStem ...
(Date:4/8/2019)... , ... April 08, 2019 , ... ... communications and collaboration solutions, announced today the launch of their app integration solution, ... range of business and contact-orientated applications while using CT Cloud Voice and Skype ...
(Date:4/8/2019)... ... April 09, 2019 , ... ... non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has chosen Geneious Biologics to ... is part of CZ Biohub’s efforts to establish new approaches to inform the ...
(Date:4/4/2019)... ... 03, 2019 , ... LeadingBiotech, an exclusive event series bringing ... its Boston CEO conference to be held May 28-29, 2019 at Boston’s Four ... high-level panels and discussions from past, present and future change-makers. , ...
Breaking Biology Technology: