Navigation Links
Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

ating, so the mice weighed 15 to 30 percent more than control mice.

Determining why the lack of EP3 receptors causes increased activity and eating will likely take a great deal of experimentation. "It's a very complex phenomenon to explore," says Sanchez-Alavez. He notes that the next step in the research will be to determine whether the obese phenotype observed in the EP3 receptor deficient mice is dependent on the lack of EP3 in the central nervous system and/or peripheral organs, as EP3 is expressed in both locations.

The research has interesting implications for scientists' understanding of appetite regulation. PGE2 is known to stimulate the release of leptin-an important hormone secreted by white fat cells and a suppressor of appetite. However, in this model, lack of EP3 did not prevent leptin increase. "Something is happening there in that circuit," says Sanchez-Alavez. "The PGE2 and leptin may be interacting and controlling eating behavior."

Bartfai notes, "Inflammation as part of the obesity and metabolic syndrome is being recognized to an increasing degree. These data directly couple the lack of a particular type of inflammatory signaling via EP3R with leptin and insulin increase, glucose tolerance, and white fat accumulation, and thus may provide a very important animal model for determining the importance of inflammation in obesity and in the conversion of obesity to type 2 diabetes."

Ultimately, better understanding of the role of EP3 receptors in feeding and obesity could lead to the development of treatments that could prevent or reverse these conditions.

Along with Sanchez-Alavez and Bartfai, Izabella Klein, Sara Brownell, Iustin Tabarean, Christopher Davis, and Bruno Conti, all of Scripps Research, were authors on the paper, "Night eating and obesity in the EP3R deficient mouse."


'"/>

Source:Scripps Research Institute


Page: 1 2

Related biology news :

1. Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
2. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
3. Scripps research scientists identify infertility molecule
4. Scripps research scientists solve structure of a critical innate immune system protein
5. New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon
6. Scripps Research study reveals new activation mechanism for pain sensing channel
7. Scripps research study reveals structural dynamics of single prion molecules
8. Scripps research study shows humans and plants share common regulatory pathway
9. Scripps research team sheds light on long-sought cold sensation gene
10. Columbia research lifts major hurdle to gene therapy for cancer
11. U of M researcher examines newly emerging deadly disease
Post Your Comments:
(Date:11/21/2014)... -- C-Labs LLC, a leading provider of remote and ... announced the appointment of John Traynor to ... advisor to the firm, Mr. Traynor will now oversee ... out of the C-Labs office in Redmond, ... , Chief Executive Officer. Photo - ...
(Date:11/18/2014)...  The Secure Identity & Biometrics Association (SIBA) ... the formation of The Airport Entry and Exit ... and Biometric Entry and Exit Solutions Framework for ... from BORDERPOL, the international non-profit organization that works ... regarding border security, traveler and migration systems. ...
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that seven officials ... least seven more will participate in the upcoming 2014 PDA ... Washington D.C. , Dec. 2-4. ... the regulatory agencies in the United States ... to help advance the use of metrics in the regulatory ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... a tiny ball of ice, a minimally invasive interventional ... caused by nerve damage, according to data being presented ... Meeting in New Orleans. "Cryoneurolysis could have big ... neuralgia, which can be unbearable and is very difficult ...
... reopens completely blocked bowel arteries, preventing damage and ... severe pain and leads to excessive weight loss, ... Interventional Radiology,s 38th Annual Scientific Meeting in New ... saves lives," said Daniel A. Leung, M.D., program ...
... A genetic analysis of the avian flu virus responsible ... virus evolving to adapt to human cells, raising concern about ... The collaborative study, conducted by a group led by Masato ... Infectious Diseases, and Yoshihiro Kawaoka of the University of Wisconsin-Madison ...
Cached Biology News:Freezing nerves knocks pain out cold 2Stenting blocked bowel arteries saves lives 2New bird flu strain seen adapting to mammals, humans 2
(Date:11/22/2014)... 2014 During his lifetime Richard L. ... to surround himself with great people and take risks ... friends often marveled at his extraordinarily courageous attitude when ... and -- even with his death impending—that’s how he ... that would ultimately take his life. , Carrying on ...
(Date:11/22/2014)... 22, 2014 The “Chiral Chromatography ... by Material (Metal, Glass, Plastic), by Application [GC, ... - Forecast to 2018” analyses and studies the ... North America, Europe, Asia, and Rest of the ... 15 figures spread through 135 pages and in-depth ...
(Date:11/21/2014)... --  TRU-D SmartUVC LLC and its UK partners, Rapid ... robot, TRU-D SmartUVC, at FIS 2014 in Harrogate, ... at Stand 23. The conference, hosted by Federation ... largest infection-related event of its kind and brings together ... leading events of its type throughout the world. This annual ...
(Date:11/21/2014)... (PRWEB) November 20, 2014 ... (XNA, Chassis, Oligos, Enzymes, Cloning kits), Technology ... Application (Biofuels, Pharmaceuticals, Biomaterials, Bioremediation) - Global ... major market drivers, threats, opportunities, and challenges. ... 46 figures spread through 185 pages and ...
Breaking Biology Technology:Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4
... Pharmaceuticals, Inc.,(Nasdaq: AMLN ) will be presenting at ... 2008 at 10:00 a.m. PT in Las Vegas. Michael,York, ... providing a corporate overview., The live presentation and ... made available following the event. The webcast and,recording will ...
... Agreement expands Dermagraft presence within government channels, ... May 7 Advanced,BioHealing, Inc. (ABH) and ... on the promotion of Dermagraft(R) within the ... of the agreement,Regenesis will provide its specialized ...
... Demonstrate Abbott,s Most Advanced NNR Candidate ABT-089 ... Adults With ADHD, ABBOTT PARK, Ill., May ... leading scientists will present new Phase II data ... agonist, is a,potentially effective and safe treatment for ...
Cached Biology Technology:Advanced BioHealing and Regenesis Biomedical Form Co-Promotion Alliance for Dermagraft(R) 2Advanced BioHealing and Regenesis Biomedical Form Co-Promotion Alliance for Dermagraft(R) 3Abbott Scientists Present a New Approach for Treating Attention-Deficit Hyperactivity Disorder 2Abbott Scientists Present a New Approach for Treating Attention-Deficit Hyperactivity Disorder 3Abbott Scientists Present a New Approach for Treating Attention-Deficit Hyperactivity Disorder 4Abbott Scientists Present a New Approach for Treating Attention-Deficit Hyperactivity Disorder 5
... Round Well Plate Sterile ... wide range of 384-well ... high-throughput screening and research. ... assays and are suitable ...
Request Info...
Aldolase A (N-15)...
Bovine Aortic Smooth Muscle Cells (BAOSMC) (>500,000 cells)...
Biology Products: