Navigation Links
Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

ating, so the mice weighed 15 to 30 percent more than control mice.

Determining why the lack of EP3 receptors causes increased activity and eating will likely take a great deal of experimentation. "It's a very complex phenomenon to explore," says Sanchez-Alavez. He notes that the next step in the research will be to determine whether the obese phenotype observed in the EP3 receptor deficient mice is dependent on the lack of EP3 in the central nervous system and/or peripheral organs, as EP3 is expressed in both locations.

The research has interesting implications for scientists' understanding of appetite regulation. PGE2 is known to stimulate the release of leptin-an important hormone secreted by white fat cells and a suppressor of appetite. However, in this model, lack of EP3 did not prevent leptin increase. "Something is happening there in that circuit," says Sanchez-Alavez. "The PGE2 and leptin may be interacting and controlling eating behavior."

Bartfai notes, "Inflammation as part of the obesity and metabolic syndrome is being recognized to an increasing degree. These data directly couple the lack of a particular type of inflammatory signaling via EP3R with leptin and insulin increase, glucose tolerance, and white fat accumulation, and thus may provide a very important animal model for determining the importance of inflammation in obesity and in the conversion of obesity to type 2 diabetes."

Ultimately, better understanding of the role of EP3 receptors in feeding and obesity could lead to the development of treatments that could prevent or reverse these conditions.

Along with Sanchez-Alavez and Bartfai, Izabella Klein, Sara Brownell, Iustin Tabarean, Christopher Davis, and Bruno Conti, all of Scripps Research, were authors on the paper, "Night eating and obesity in the EP3R deficient mouse."


'"/>

Source:Scripps Research Institute


Page: 1 2

Related biology news :

1. Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
2. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
3. Scripps research scientists identify infertility molecule
4. Scripps research scientists solve structure of a critical innate immune system protein
5. New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon
6. Scripps Research study reveals new activation mechanism for pain sensing channel
7. Scripps research study reveals structural dynamics of single prion molecules
8. Scripps research study shows humans and plants share common regulatory pathway
9. Scripps research team sheds light on long-sought cold sensation gene
10. Columbia research lifts major hurdle to gene therapy for cancer
11. U of M researcher examines newly emerging deadly disease
Post Your Comments:
(Date:10/30/2014)... help reduce or reverse soil subsidence and reduce ... Sacramento-San Joaquin River Delta by Dartmouth College researchers ... one of the first to continually measure the ... cycle through wetlands, appears in the journal by ... Worldwide, agricultural drainage of organic soils has resulted ...
(Date:10/30/2014)... This news release is available in German . ... we as individuals prompt our fellow humans to behave ... to social dilemmas in game theory. Previous studies assumed ... large groups. Nonetheless, scientists from the Max Planck Institute ... us can exert an influence on the cooperative behaviour ...
(Date:10/30/2014)... State University researchers have developed a suite of technologies ... and humans, which has applications in everything from search ... , "We,ve developed a platform for computer-mediated communication between ... avenues for interpreting dogs, behavioral signals and sending them ... Roberts, an assistant professor of computer science at NC ...
Breaking Biology News(10 mins):Dartmouth study finds restoring wetlands can lessen soil sinkage, greenhouse gas emissions 2Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4New tech aims to improve communication between dogs and humans 2
... German . , , "Watch out, it,ll hurt for a ... they hear those words from their doctor. And, as soon as ... very clearly. "After such an experience it is enough to simply ... pain memory", knows Prof. Dr. Thomas Weiss from the Friedrich-Schiller-University Jena. ...
... toads, salamanders, and newtsare disappearing worldwide, but the stream ... This region is home to the largest diversity of ... here), and scientists want to understand what contributes to ... in the March 29, 2010 issue of the ...
... Bionic Vision Australia (BVA) today unveils their wide-view ... implanted into Australia,s first recipient of the technology. ... at the University of New South Wales and unveiled ... University of Melbourne, will deliver improved quality of life ...
Cached Biology News:Do words hurt? 2Young salamanders' movement over land helps stabilize populations 2Young salamanders' movement over land helps stabilize populations 3Bionic Vision Australia puts bionic eye in sight 2
(Date:10/30/2014)... October 30, 2014 SoundConnect ... provider, offers Office 365 end users the key ... complete phone system by adding voice enablement and ... includes Lync Online, a communication tool that includes ... With hosted voice, O365 becomes a comprehensive unified ...
(Date:10/30/2014)... James Sherley says he has been working ... cell technology since his days as a principal investigator at ... late 1990’s. Sherley founded the ASCTC as a new ... the intellectual property developed in Sherley’s research over the years ... of Technology (MIT), and more recently as a senior scientist ...
(Date:10/30/2014)... October 30, 2014 Whitehouse Laboratories has ... ICH Stability Testing and Package Test Capacity. Responding to ... on a dramatic increase in environmental chamber storage space ... storage and aging samples to be securely held on ... major capital expenditure has already taken place with the ...
(Date:10/30/2014)... October 30, 2014 Grace Century portfolio project, ... A. Manganello, Chairman of the Board, to the National ... The appointment was made by the Ministry of Health on ... 2014. , More than a year after Bahamian ... , Prime Minister Perry Christie said the government has completed ...
Breaking Biology Technology:SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3
... PARI Respiratory Equipment,s,breath-enhanced nebulizer, the PARI ... L.P.,s new COPD medication, Perforomist Inhalation Solution,that ... subsidiary of Mylan Inc.,(NYSE: MYL ). ... indicated for,long-term, twice-daily maintenance treatment of bronchoconstriction ...
... WASHINGTON, D.C., October 9 Bavarian Nordic,the Danish-based ... of Health and Human Services (HHS) to,invoice an ... the recent,contract (RFP-3)* to manufacture and deliver 20 ... HHS approved the advance payment because Bavarian Nordic ...
... Patient-Safety ... Technology,eRx NOW(TM) Functionality Expanded to ... Physician Portal Lab Order and Results Capabilities, LYNDHURST, N.J. and ... leading provider of,diagnostic testing, information and services and a leading developer of,healthcare ...
Cached Biology Technology:PARI Respiratory's LC PLUS & PRONEB Ultra Deliver Dey, L.P.'s New COPD Therapy; Perforomist Launched Yesterday 2PARI Respiratory's LC PLUS & PRONEB Ultra Deliver Dey, L.P.'s New COPD Therapy; Perforomist Launched Yesterday 3PARI Respiratory's LC PLUS & PRONEB Ultra Deliver Dey, L.P.'s New COPD Therapy; Perforomist Launched Yesterday 4Bavarian Nordic Receives $50 Million Advance Payment from HHS for Fulfilling Contract Milestones 2Bavarian Nordic Receives $50 Million Advance Payment from HHS for Fulfilling Contract Milestones 3Quest Diagnostics Joins National ePrescribing Patient Safety Initiative (NEPSI) 2Quest Diagnostics Joins National ePrescribing Patient Safety Initiative (NEPSI) 3Quest Diagnostics Joins National ePrescribing Patient Safety Initiative (NEPSI) 4Quest Diagnostics Joins National ePrescribing Patient Safety Initiative (NEPSI) 5
... is commonly used as a fusion partner ... The GSTTag sequence has been reported to ... the solubility of its fusion partners. When ... GSTTag fusion proteins can be purified with ...
... The LX80L is an extension of Parkers ... maintaining a compact cross-section. LX80L bolt hole patterns ... mount MX80 units and all accessory brackets to ... stage with travel to 750 mm , Accelerations ...
... PEP-005 is a synthetic peptide whose sequence is from the C-terminal end ... acid sequence extends from amino acids 429 to 448 of RAR*. ... - S - V - S - P - S - S ... - S - Q - S - P - L - L ...
... Rat Neural Stem Cell Kit with ... cells (NCSs) complete with optimized base medium ... and plate these unique cells generated from ... you need for a tissue-like mixture of ...
Biology Products: