Navigation Links
Scripps research study shows humans and plants share common regulatory pathway

The study was published in an advance online edition of the Proceedings of the National Academy of Sciences during the week of April 9, 2007.

The study provides new evidence that Nod1, a member of the Nod-like Receptor (NLR) protein family, is activated by the protein SGT1, which also activates Resistance (R) proteins in plants; R proteins protect plants from various pathogens. The study also confirms structural similarities between the Nod1 protein, which plays a pivotal role in the innate immune system’s recognition and response to bacterial infection and members of the R protein family.

"There has been a great deal of speculation that R proteins and Nod1 are related, but our study provides the first direct link between plants and humans," said Richard Ulevitch, the Scripps Research scientist whose laboratory conducted the study. "Plants have Nod-like receptors and similar immune responses to bacteria and other pathogens-the R proteins evolved to counteract these pathogenic effects. Our study provides a new perspective on the Nod1 pathway in mammalian cells as well as the value of drawing on plant studies of R protein pathways to better understand the pathogen recognition functions of these proteins."

The Nod proteins recognize invasive bacteria, specifically distinct substructures found in Gram-negative and Gram-positive organisms. Once activated, Nod1 produces a number of responses that include activation of intracellular signaling pathways, cytokine production and apoptosis or programmed cell death. Despite the fact that various models of Nod1 activation have been described, little has been known about other proteins that might affect the protein’s activation. In contrast, a number of additional proteins have been linked to the activation pathways of the R protein in plants.

"The NLR family has clear links to human disease," Ulevitch said. "Out of the more than 20 proteins in the NLR family, several mutations are linked t
'"/>

Source:Scripps Research Institute


Page: 1 2 3

Related biology news :

1. Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
2. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
3. Scripps research scientists identify infertility molecule
4. Scripps research scientists solve structure of a critical innate immune system protein
5. New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon
6. Scripps Research study reveals new activation mechanism for pain sensing channel
7. Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
8. Scripps research study reveals structural dynamics of single prion molecules
9. Scripps research team sheds light on long-sought cold sensation gene
10. Columbia research lifts major hurdle to gene therapy for cancer
11. U of M researcher examines newly emerging deadly disease
Post Your Comments:
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into ... key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security ... an end to the frustration that comes with usernames, passwords ... a user,s smartphone to acquire his or her biometrics to ...
(Date:12/10/2014)... 08, 2014 Research and Markets ... the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration of ... rural banking and upgradation of the driver,s license ... the market. Besides the aforementioned projects, biometrics is ...
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... survival strategy of the parasite that causes sleeping sickness could ... found that the parasite, which can transform itself into either ... these. One of these types ensures infection in the bloodstream ... by the tsetse fly and spread to another person or ...
... is available in German . It would ... would have similar genetic blueprints. However, scientists from the Max ... with an international research team have now decoded, for the ... ( Arabidopsis lyrata ), a close relative of the thale ...
... release is available in Spanish . ... Agriculture (USDA) scientists and colleagues can improve polymerase chain ... PCR-based tests are prized tools for diagnosing plant ... among other economic harm. But the test,s ability to ...
Cached Biology News:Evolution can cause a rapid reduction in genome size 2Evolution can cause a rapid reduction in genome size 3New technique improves sensitivity of PCR pathogen detection 2
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the nation’s ... Pharm.D. to the newly created position of Vice President ... Dr. Maroulis will continue to manage the entire specialty ... pharmacies as the company expands. Dr. Maroulis has been ... has served in many different capacities in the pharmacy, ...
(Date:12/19/2014)... 2014 Research and Markets ( ... "Technology Innovations in Smart Fabrics (Technical Insights)" ... http://photos.prnewswire.com/prnh/20130307/600769 The Research ... a detailed assessment on technological advancements and market ... 1. The Smart Fabrics market is ...
(Date:12/19/2014)... Reports from CDC show approximately ... one or more chronic health conditions - including cardiovascular ... some of these diseases, but may not eliminate the ... While implanted nerve stimulation devices today offer relief, they ... can induce side effects. , To eliminate the ...
(Date:12/19/2014)... Mass. , Dec. 18, 2014  Decision Resources ... dental biomaterial market will grow moderately through 2023 ... procedures and growing awareness of dental biomaterials all spur ... markets such as China and ... will bring dental procedures within reach for a larger ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Technology Innovations in Smart Fabrics (Technical Insights) 2Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3
... Development of Nano-Materials for Angiogenesis Applications , ... OmegaGenesis announced today that they have entered into a ... nano-materials used for Angiogenesis applications. , , ... variety of medical applications ranging from tissue reactivation and healing ...
... 3 Combination Rule Trial for NDA Submission , ... N.J., Dec. 15 QRxPharma Limited (ASX: QRX and ... the development and commercialization of therapies for pain and ... a comparative study to evaluate the efficacy and safety ...
... N.Y., Dec. 15 Allscripts,announced today that ... multispecialty group practice, has selected Allscripts,Practice Management ... for their 190 physicians. , ... ) , ...
Cached Biology Technology:OmegaGenesis Announces Angiogenesis Application Collaboration 2OmegaGenesis Announces Angiogenesis Application Collaboration 3QRxPharma Initiates Comparative Study for MoxDuoIR(TM) Dual-Opioid(TM) Pain Therapy 2QRxPharma Initiates Comparative Study for MoxDuoIR(TM) Dual-Opioid(TM) Pain Therapy 3Community Care Physicians Selects Allscripts Practice Management System for 190 Physicians in New York Capitol Region 2Community Care Physicians Selects Allscripts Practice Management System for 190 Physicians in New York Capitol Region 3Community Care Physicians Selects Allscripts Practice Management System for 190 Physicians in New York Capitol Region 4Community Care Physicians Selects Allscripts Practice Management System for 190 Physicians in New York Capitol Region 5
Anti-DDDDK-Tag (Enterokinase Cleavage Site), Agarose Conjugate Research Focus: tag Storage: 4C Shipping Temperature: 4C...
Goat polyclonal to XAGE1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGFGFRRQGEDNT, corresponding to C terminal amino acids 149-160 of Human XAGE1 Entrez Gene ID: 9...
Sheep polyclonal to Staphylococcus DNase ( Abpromise for all tested applications). Antigen: Full length native protein (purified)....
Mouse monoclonal [MN-8C4] to zona radiata ( Abpromise for all tested applications). Antigen: Purified eggshell proteins (zona radiata proteins and small amounts of zona pellucida proteins) from ...
Biology Products: