Navigation Links
Scripps research scientists identify infertility molecule

an embryo, it must descend to the womb and implant there, where it will grow into a fetus. But the factors that control whether an embryo is able to implant successfully inside a womb have not been known.

Now Chun and his colleagues have discovered a new molecular pathway that influences fertility, at least in mice -- and one that directly affects the ability of mouse embryos to implant in their mother's womb.

LPA Receptors and Implantation

The pathway that affects implantation involves a particular type of receptor molecule -- a protein called a lysophosphatidic acid (LPA) receptor that can be found on the surfaces of cells in the brains and in the uteruses of mammals, where it binds to LPA, one type of phospholipid.

Phospholipids, molecules of fat with a charged head on one end, are commonly found in biological organisms and are generally regarded as essential structural components of cells. For instance, bilayers of phospholipids are the primary component of cellular membranes, those essential barriers that define the boundaries of cells and keep the molecules inside a cell separated from those outside a cell.

But many phospholipids are more than just simple structural elements. Some play significant signaling roles in the cell. LPA belongs to a family of phospholipids known as "lysophospholipids." These molecules play a more active role in the mammalian body, acting as signals for many different developmental events and adult physiology.

Chun and his colleagues identified the first lysophospholipid receptor about ten years ago, when he was at the University of California, San Diego, and since then eight more of these receptors have been identified. The LPA receptors are all proteins of the type known as a G protein-coupled receptor (GPCR). This is a common type of receptor molecule in the body, and an important class of targets for the design of drugs. Indeed, about half of the medicines on the market target such
'"/>

Source:Scripps Research Institute


Page: 1 2 3 4 5

Related biology news :

1. Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
2. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
3. Scripps research scientists solve structure of a critical innate immune system protein
4. New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon
5. Scripps Research study reveals new activation mechanism for pain sensing channel
6. Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
7. Scripps research study reveals structural dynamics of single prion molecules
8. Scripps research study shows humans and plants share common regulatory pathway
9. Scripps research team sheds light on long-sought cold sensation gene
10. Columbia research lifts major hurdle to gene therapy for cancer
11. U of M researcher examines newly emerging deadly disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scripps research scientists identify infertility molecule

(Date:8/28/2014)... mobile app called TX Invasives is now available from ... of Texas at Austin for identifying harmful non-native plant, ... species in the United States cause about $137 billion ... agricultural crops, clog waterways, kill native plants and more. ... app for reporting where invasive species occur, we,re more ...
(Date:8/28/2014)... an expansion of marine protected areas is needed to ... According to investigators from the Wildlife Conservation Society and ... on saving the largest numbers of species, often at ... difficult-to-replace ecological functions. , Many vital ecological ... that also are food for millions of people. ...
(Date:8/28/2014)... Access to Research Careers) Program has announced the travel ... from October 18 22, 2014 in San Diego, ... entry of students, post doctorates and scientists from underrepresented ... and to encourage the participation of young scientists at ... MARC conferred 16 awards totaling $29,600., The FASEB MARC ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... body are constantly dividing to maintain our body functions. At ... supporting components has to be faithfully duplicated to maintain the ... of Copenhagen, have developed a new technology that has revealed ... of cellular memory. The results are published in Nature ...
... urgently needs a green economic strategy to move towards ... new report published today by UCL,s Green Economy Policy ... range of academic disciplines across UCL argues that ... resource constraints mean that decisive action is urgently needed ...
... YORK, NY (February 23, 2014) Columbia University Medical ... of the hippocampus known as CA2 is essential for ... another of the same species. A better grasp of ... and treating disorders characterized by altered social behaviors, such ...
Cached Biology News:New technology detect cellular memory 2Policies to green the economy must underpin UK recovery: New report 2Policies to green the economy must underpin UK recovery: New report 3Researchers pinpoint brain region essential for social memory 2Researchers pinpoint brain region essential for social memory 3
(Date:8/28/2014)... a Florida State University research team has led to ... emit white light, and convert photon energy directly to ... butterfly. , Biwu Ma, associate professor in the Department ... of Engineering, created the molecule in a lab about ... his creation has many other unique capabilities. , For ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a leading ... to support their communication needs with the ... conferencing platform GlobalMeet powered by SoundConnect. The solution ... SoundConnect delivers award winning “results driven” business class ... be utilizing GlobalMeet powered by SoundConnect ...
(Date:8/27/2014)... 27, 2014 Green & Grow Inc. ... B funding and secured Otter Capital as a significant ... accelerate commercialization of GGI’s Agriplier™ technology, building on recent ... , “Since our first meeting, we have been impressed ... product space,” said Alan Sobba, President and CEO of ...
(Date:8/27/2014)... 2014   MSC , a healthcare performance improvement ... the appointment of Mary Beth Loesch to ... of experience preparing companies for rapid growth and market ... President of Corporate Development and Healthcare. In that role, ... as well as corporate strategy and marketing. Previously, Loesch ...
Breaking Biology Technology:Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3MSC names Mary Beth Loesch President and CEO 2
... , NEW YORK, June 15 NeoStem, Inc. (NYSE ... pre-disease collection, processing and long-term storage of adult stem ... signed an exclusive 10-year agreement with Enhance BioMedical Holdings ... Collection and Treatment Network using NeoStem,s proprietary adult stem ...
... , ... announces new facility which will add capacity, additional capabilities to growing laboratory in order to ... ... new facility which will more than triple the company,s previous capacity and will accommodate projected ...
... ... Positives , ... NY (PRWEB) June 15, 2009 -- iCardiac Technologies, Inc., a leader in advanced cardiac ... a medium sized pharmaceutical company for cardiac safety evaluation comprising multiple Thorough QT (TQT) ...
Cached Biology Technology:NeoStem Signs Agreement with Shanghai Corporation to Develop A Stem Cell Collection and Treatment Network in Shanghai, Taiwan and Other Targeted China Provinces 2NeoStem Signs Agreement with Shanghai Corporation to Develop A Stem Cell Collection and Treatment Network in Shanghai, Taiwan and Other Targeted China Provinces 3NeoStem Signs Agreement with Shanghai Corporation to Develop A Stem Cell Collection and Treatment Network in Shanghai, Taiwan and Other Targeted China Provinces 4CoreRx, Inc. Announces Plans for Expansions to Meet the Needs of Growing Pharmaceutical Formulation Development Business 2iCardiac Selected for Multiple Cardiac Safety Studies 2
Homo sapiens CDC23 (cell division cycle 23, yeast, homolog),...
Terrific Broth, 1 kg. Mixture of casein peptone, yeast extract, K2HPO4, and KH2PO4.Used at 47 g/l for E. coli growth with higher cell densities. Category: Nucleotides & Enzymes & Biochemicals, Ultrap...
(3-[125I]iodotyrosyl26)Galanin (porcine), 925 kBq, 25 uCi. Category: IODINE LIGANDS....
Immunogen: Synthetic peptide based on the sequence: SPSSGPSLTADSMWR Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: