Navigation Links
Scratch no more: Gene for itch sensation discovered

Itching for a better anti-itch remedy" Your wish may soon be granted now that scientists at Washington University School of Medicine in St. Louis have identified the first gene for the itch sensation in the central nervous system. The discovery could rapidly lead to new treatments directly targeting itchiness and providing relief for chronic and severe itching.

The "itch gene" is GRPR (gastrin-releasing peptide receptor), which codes for a receptor found in a very small population of spinal cord nerve cells where pain and itch signals are transmitted from the skin to the brain. The researchers, led by Zhou-Feng Chen, Ph.D., found that laboratory mice that lacked this gene scratched much less than their normal cage-mates when given itchy stimuli.

The laboratory experiments confirmed the connection between GRPR and itching, offering the first evidence of a receptor specific for the itch sensation in the central nervous system. The findings are reported this week in Nature through advance online publication.

Chronic itching is a widespread problem. It can be caused by skin disorders like eczema, or it can stem from a deeper problem such as kidney failure or liver disease. It can be a serious side effect of cancer therapies or powerful painkillers like morphine. For some people, chronic itching can be very disruptive, interfering with sleep or giving rise to scratching that leads to scarring. Effective treatment options for itchy patients are limited.

Historically, scientists regarded itch as just a less intense version of the pain sensation. As a result, research on itching has been somewhat neglected. "Many genes have been identified in the pain pathway," says Chen, associate professor of anesthesiology, psychiatry and molecular biology and pharmacology. "But itch research has lived in the shadow of pain research, and no one knew which gene was responsible for itching in the brain or in the spinal cord until now."

In fact, Chen's team became i
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Scripps research team sheds light on long-sought cold sensation gene
2. Newly-discovered class of genes determines ?and restricts ?stem cell fate
3. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
4. New protein discovered by Hebrew University researchers
5. Newly Discovered Compound Blocks Known Cancer-Causing Protein
6. New RNA polymerase discovered in plants
7. Newly discovered pathway might help in design of cancer drugs
8. Same-Sex Mating Discovered in a Toxic Fungus
9. New tumor-suppressor gene discovered
10. A New Species of Monkey is Discovered in Tanzania: The First in Africa for More Than 20 Years
11. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scratch more Gene for itch sensation discovered

(Date:9/29/2014)... "human activities in this area of the world have contributed ... grown for use as a cooking oil and biofuel, while ... the most widely produced edible oil in the world, and ... soybean oil. , The environmental effects of such growth have ... crop, and the preferred method is fire. The clearing often ...
(Date:9/29/2014)... of Texas at Arlington research team says recently identified ... their lab could open doors for homeland security and ... in the Oct. 1 issue of Optics Letters ... co-authors describe a new method to fabricate transparent nanoscintillators ... until a transparent ceramic is formed. A scintillator ...
(Date:9/29/2014)... PULLMAN, Wash. Scientists at Washington State University ... specifically, Granny Smith apples may help prevent ... be the first to assess these compounds in ... in October,s print edition of the journal ... apples are a good source of these nondigestible ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3An apple a day could keep obesity away 2
... pressure were recently identified in a comprehensive international ... study, in which Uppsala University researchers participated, are ... Nature Genetics . High blood pressure ... Previous studies have shown that it is extremely ...
... May 8 Military and civilian personnel from the ... local homeland security, law enforcement and other first-responder personnel ... been encouraged to register and attend the 2009 Force ... held at Stafford Regional Airport and Marine Corps Base, ...
... and south sides of a house may decrease summertime ... a recent study* of California homes by researchers from ... the U.S. Department of Agriculture (USDA). The first ... the effects of shade on 460 single-family homes in ...
Cached Biology News:Comprehensive genetic study paves way for new blood-pressure medicines 2Demonstration Features Commercial Technology for Combating Terrorism 2New study: Home energy savings are made in the shade 2
(Date:9/30/2014)... -- The overall research objective was to capture ... use. Most researchers outsource NGS technologies; however, in-house ... the next 12 months. Data accuracy and operating ... instruments. Disease-related research is the dominant use for ... surge, with half of the respondents planning to ...
(Date:9/30/2014)... CT (PRWEB) September 30, 2014 ... of scientific research products, recently opened an online ... comprehensive cell culture product lines developed and manufactured ... its online store include Biological Industries’ Nutristem® serum-free, ... and human embryonic stem cell (hESC) culture. ...
(Date:9/30/2014)... 30, 2014 Back in the 1970’s, many ... feet. per employee, which included space for circulation and file ... Jeff Howell, partner at Nidea Corporate Real Estate / ... “By the year 2000, however, 250 square feet per ... number come down to 175 to 225 square feet, and ...
(Date:9/29/2014)... conflicts in Iraq and Afghanistan, more than 300,000 soldiers ... injury caused by exposure to bomb blasts and ... Symptoms of traumatic brain injury can range from the ... severe impairments in memory and cognition. , Since ... critical importance and complexity of this problem, and has ...
Breaking Biology Technology:Global Next-generation Sequencing Trends 2Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... -- China YCT,International Group, Inc. (OTC Bulletin ... Shandong Yongchuntang Biology Technology,Co. Ltd. ("Shandong YCT"), ... China, has been awarded the honor of ... new pharmaceuticals sector. The,award was conferred by ...
... 10 Oxford Finance Corporation and GE,Healthcare Financial ... senior secured loan to Astex Therapeutics Limited. This ... a biotechnology company in,Europe., Astex Therapeutics, based ... biotech companies in the UK, concentrating on the ...
... Gastroenterology Panel Discussion, ISELIN, N.J., Dec. 10 ... Executive Officer Elkan R. Gamzu,Ph.D. will participate in a ... Conference taking place December 12,- 13, 2007 at the ... New York.,The panel is entitled "Going With Your Gut: ...
Cached Biology Technology:CYIG Awarded China's "Top 100 Enterprises" in New Pharmaceuticals, Selected as National "'Torch Plan' Key High-Tech Enterprise" 2Oxford Finance Corporation and GE Healthcare Financial Services Reaffirm Commitment to Biotech Sector in Europe 2Pharmos Corporation to Present at the 2007 RBC Capital Markets Healthcare Conference 2
... EZ-Spread Plating Beads Sterile plating in ... glass rods and potentially hazardous ethanol flaming, ... choices of ready-to-use sterile packaging: dispenser bottle for ... plating, Fastest and easiest way to ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... a regulated environment, Pipette Tracker Pro ... that automates gravimetric pipette calibration and ... meets todays regulatory compliance requirements. Pipette ... that includes a full security implementation, ...
... the yolk protein Vtg in plasma from juvenile ... biomarker for endocrine disrupting chemicals (EDCs) with estrogenic ... an accepted screening test for the estrogenic effects ... EIA kit is a double-antibody immunometric (sandwich) EIA ...
Biology Products: