Navigation Links
Scratch no more: Gene for itch sensation discovered

Itching for a better anti-itch remedy" Your wish may soon be granted now that scientists at Washington University School of Medicine in St. Louis have identified the first gene for the itch sensation in the central nervous system. The discovery could rapidly lead to new treatments directly targeting itchiness and providing relief for chronic and severe itching.

The "itch gene" is GRPR (gastrin-releasing peptide receptor), which codes for a receptor found in a very small population of spinal cord nerve cells where pain and itch signals are transmitted from the skin to the brain. The researchers, led by Zhou-Feng Chen, Ph.D., found that laboratory mice that lacked this gene scratched much less than their normal cage-mates when given itchy stimuli.

The laboratory experiments confirmed the connection between GRPR and itching, offering the first evidence of a receptor specific for the itch sensation in the central nervous system. The findings are reported this week in Nature through advance online publication.

Chronic itching is a widespread problem. It can be caused by skin disorders like eczema, or it can stem from a deeper problem such as kidney failure or liver disease. It can be a serious side effect of cancer therapies or powerful painkillers like morphine. For some people, chronic itching can be very disruptive, interfering with sleep or giving rise to scratching that leads to scarring. Effective treatment options for itchy patients are limited.

Historically, scientists regarded itch as just a less intense version of the pain sensation. As a result, research on itching has been somewhat neglected. "Many genes have been identified in the pain pathway," says Chen, associate professor of anesthesiology, psychiatry and molecular biology and pharmacology. "But itch research has lived in the shadow of pain research, and no one knew which gene was responsible for itching in the brain or in the spinal cord until now."

In fact, Chen's team became i
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Scripps research team sheds light on long-sought cold sensation gene
2. Newly-discovered class of genes determines ?and restricts ?stem cell fate
3. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
4. New protein discovered by Hebrew University researchers
5. Newly Discovered Compound Blocks Known Cancer-Causing Protein
6. New RNA polymerase discovered in plants
7. Newly discovered pathway might help in design of cancer drugs
8. Same-Sex Mating Discovered in a Toxic Fungus
9. New tumor-suppressor gene discovered
10. A New Species of Monkey is Discovered in Tanzania: The First in Africa for More Than 20 Years
11. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scratch more Gene for itch sensation discovered

(Date:9/2/2014)... A study published in the September 2014 ... Academy of Child and Adolescent Psychiatry found ... diagnosis had an increased risk of developing diabetes ... data from the nationwide Danish registers, a group ... Psychiatry, Aalborg University Hospital, Denmark, studied 48,299children and ...
(Date:9/2/2014)... Bavaria, the Tithonian Konservat-Lagersttte of lithographic limestone is ... of emblematic fossils from that area (for example, ... found fossil insects in the French equivalent of ... species representing the oldest known water treader. , ... Bavarian outcrops, fewer fossils have been obtained from ...
(Date:9/1/2014)... has improved steadily in recent yearsspurred in large part ... poor and disparities continue to widen among socioeconomic and ... School of Public Health (HSPH). , "The study provides ... efforts by many groups and individuals to improve U.S. ... indicates that these efforts need to be expanded," said ...
Breaking Biology News(10 mins):Risk of diabetes in children and adolescents exposed to antipsychotics 2Exceptionally well preserved insect fossils from the Rhône Valley 2Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3
... Spiders may not be the pure predators we generally believe, after ... diet by eating pollen. Dr Dirk Sanders of the University ... garden variety choose to eat pollen even when insects are ... trap aerial plankton like pollen and fungal spores. Dr Sanders, ...
... Dec. 17, 2013 Going back in time to compare ... , a University of Houston (UH) biologist hopes to one ... the likelihood it will become resistant to a particular antibiotic. ... is allowing associate professor Timothy Cooper and his team to ...
... one of the most diverse and abundant groups of ... important invasive insect pests around the globe. In the ... the avocado industry in Florida, and Asian ambrosia beetles ... are attacking trees in nurseries. However, despite their economic ...
Cached Biology News:Predicting antibiotic resistance among goals of UH research 2Meet the beetles -- the Xyleborini of New Guinea 2
(Date:9/2/2014)... , Sept. 2, 2014  Spherix Incorporated (SPEX) -- an ... monetization of intellectual property, today announced that the United ... to the Company in the month of August that ... The issued patents are: ... U.S.RE45,081 issued August 19, 2014; and , U.S.RE45,095 ...
(Date:9/1/2014)... The Collaborative R&D Terms and Agreements ... understanding and unprecedented access to the collaborative R&D ... leading life science companies. , The report provides ... why companies enter collaborative R&D deals. , Understanding ... terms provides critical insight into the negotiation process ...
(Date:8/30/2014)... TX (PRWEB) August 31, 2014 ... is a professional and in-depth study on the ... in Global and China. , The report provides ... applications and industry chain structure. Global market analysis ... a focus on history, developments, trends and competitive ...
(Date:8/29/2014)... August 29, 2014 Pittcon is pleased ... and colleague Koichiro Matsuda, Horiba Scientific, have organized a ... 5, 2014. JASIS , Asia’s largest analytical and ... in Makuhari Messe, Japan. , The four speakers ... Bioanalysis from Single Molecules to Single Cells” will present ...
Breaking Biology Technology:United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2
... PHILADELPHIA, Dec. 11 The following is,GlaxoSmithKline,s ... retrospective analysis by the,Institute for Clinical Evaluative ... Older Patients with,Diabetes"., GSK believes that ... Drug,Benefit (ODB) database has significant limitations and ...
... Replikins Ltd. today announced its,latest findings regarding ... The company,s software-driven analysis has found that the ... in addition, higher,counts now have been found in ... which has been linked to the lethality of,influenza ...
... ROCHESTER, N.Y., Dec. 11 Lucid, Inc., (http://www.lucid-tech.com ... has appointed Dr. Colin Stahel as Director, Asia ... was selected for the newly created,position based on ... twenty years of experience in the development of ...
Cached Biology Technology:GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 2GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 3GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 4GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 5Lethal Human H5N1 Influenza Virus Replikin Gene Still Upregulated 2Lucid Expands Support Internationally: Dr. Colin Stahel appointed Director for Asia Pacific Region 2
... by end-users to be "a delight to ... light microscopy and electronic imaging. With its ... not require much space and can easily ... The DM-BA300 combines Motic's own revolutionary Colour ...
When added to StemSep T Cell Enrichment cocktail, human TCRab TAC is designed to deplete human TCRab from samples to isolate gd T cells....
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human CD45RA TAC is designed to deplete human CD45RA from samples to isolate memory CD4+ or CD8+ T cells....
... 'SoftLinx software, a multitasking application capable ... the programming and operation of lab automation ... enough for custom modification by programmers. ... a simple drag-anddrop flowchart. If you can ...
Biology Products: