Navigation Links
Scientists use gene transfer technology and common virus to block neuropathic pain in animals

degree of pain the animal is feeling.

One week after surgery, some of the rats received injections of the HSV vector with GAD, while control rats did not receive the vector. Rats given the transgene vector had significantly lower pain threshold responses to filament touch and heat exposure tests than rats that did not receive the vector.

“We saw a sustained, continuous pain-suppressing effect that began one week after inoculation with the vector and lasted for six weeks,?says Marina Mata, M.D., staff neurologist at the VA Ann Arbor Healthcare System, professor of neurology in the U-M Medical School and co-director of the research team. “By seven weeks after inoculation, the pain-blocking effect disappeared, but a second inoculation into the same paw re-established the effect.?/p>

In previous research, Mata and Fink have used their HSV vector to deliver other neurotrophic factors and pain-suppressing drugs to spinal ganglion cells. But Fink says the effect of the GAD-expressing vector is substantially greater for neuropathic pain, because it helps correct the reduction of GABA in the spinal cord. He also emphasizes the excellent safety record of the HSV vector, which has produced no side effects or complications in many animal studies.

“I am a clinical neurologist and I see patients with neuropathic pain,?Fink says. “These patients suffer tremendously and the treatments available to us now have limited effectiveness. Using our herpes vector to provide targeted gene delivery to the nervous system is a novel approach that shows tremendous promise for the treatment of neuropathic pain.?/p>

In future research, the scientists plan to conduct the first phase I safety trial of a related HSV vector in patients with pain caused by terminal cancer, which has spread to bone.

The research was supported by grants from the National Institute of Neurological Disorders and Stroke and the Department of Veterans Affairs. Additional collaborator
'"/>

Source:University of Michigan


Page: 1 2 3 4 5

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:8/12/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is proud to announce that iMedNet ... platform, has led the way to significant and unprecedented ...   Q2 2015 and Q1 2015 were, respectively, the ... sold in the company,s 15 year history.  In addition, ...
(Date:8/12/2015)... , Aug. 12, 2015  New research ... can attack Android phones to steal users, fingerprints. ... increasing availability of fingerprint scanners on mobile devices, ... concern. To secure biometrics on mobile devices, HYPR ... augment these convenient authentication systems with strong cryptographic ...
(Date:8/11/2015)... -- Today, ZUK announced its Android smartphone Z1, featuring ... revenues in 2015 that relate to sales of FPC1155 for this ... 2,200 MSEK for 2015. Jörgen Lantto, CEO of FPC, ... smartphone manufacturer in China and we ... 155 for Z1 , ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... development and successful lab tests of "killer paper," a ... material that helps preserve foods by fighting the bacteria ... Langmuir , contains a coating of silver nanoparticles, ... and colleagues note that silver already finds wide use ...
... advance toward development of a way to combat the terrible ... inflict billions of dollars of damage to crops each year ... Organic Letters . Teck-Peng Loh and colleagues ... food crops such as potatoes and soybeans as well as ...
... on newborn infants for 40 years is finding a second ... an article in the current edition of Chemical & Engineering ... Celia Henry Arnaud notes that collecting drops of blood from ... dry has been used for decades to screen newborns for ...
Cached Biology News:
(Date:8/28/2015)... ... August 28, 2015 , ... Pittcon is pleased ... present a session on chemical spectroscopic imaging at JASIS 2015 (Japan Analytical & ... largest analytical and scientific instruments show which will be held at International Conference ...
(Date:8/28/2015)... ... 28, 2015 , ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the ... service. Images such as the Fonz in a lab coat and Large Marge have ... humdrum spectroscopy field. , FireflySci is proud to be the only cuvette manufacturer ...
(Date:8/27/2015)... -- Neogen Corporation (NASDAQ: NEOG ) announced today that ... Kingdom -based Lab M Holdings, a developer, manufacturer ... Lab M was founded in 1971, ... testing and diagnostic products for the global food, water, ... into more than 70 countries worldwide, and has several ...
(Date:8/27/2015)... PARK, Calif. , Aug. 27, 2015  Asterias ... in the emerging field of regenerative medicine, today announced ... investor conferences in the month of September.  ... will present at Rodman & Renshaw,s 17th Annual Global ... ET/7:25am PT at the St. Regis Hotel in ...
Breaking Biology Technology:U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 2U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 3Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Neogen acquires U.K.-based Lab M Holdings 2Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2
... At the end of December,Trinitas Comprehensive Cancer Center became ... of New Jersey to offer cancer patients treatment using,RapidArc(TM) ... VAR ).,RapidArc is a fast, precise form of treatment ... possible with conventional radiation therapy,technologies. By delivering radiation ...
... Jan. 13 Responding to the increased risk to,patient ... Foundation,has announced that the 2009 NPSF Patient Safety Congress ... educational sessions designed to,provide attendees with the new thinking ... (Logo: http://www.newscom.com/cgi-bin/prnh/20080307/AQF053LOGO ) , ...
... and NEW HOPE, Pa., Jan. 13 ... Delhi, announced today that its,Bangalore-based subsidiary, Jubilant ... partnership with BioLeap, LLC, USA. Under ... leading edge computational fragment,based drug design platform ...
Cached Biology Technology:Trinitas Comprehensive Cancer Center Now Offering Cancer Patients Faster, Ultra-Precise Radiation Using New RapidArc Technology 2Trinitas Comprehensive Cancer Center Now Offering Cancer Patients Faster, Ultra-Precise Radiation Using New RapidArc Technology 3Patient Safety in Challenging Economic Times is Focus of NPSF Annual Congress on May 20-22 2Jubilant and BioLeap Announce New Partnership in Drug Discovery 2Jubilant and BioLeap Announce New Partnership in Drug Discovery 3
... or 384-well PCR plates Dimples on both sides ... plates End tabs on Thermo-Mat™ 384 fit into ... sealing is achieved with either Thermo-Mat™ 96 or 384 ... lid thermal cyclers Fully autoclavable May ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,667-7) ... assistance. ID clarifier: barcoded, bulk ...
Packaging: package with 500 l Patent/trademark/license (electronic): (r) Registered trademark of Molecular Probes...
... easy method for the isolation of ... tissues. Most of the isolated mitochondria ... The kit contains extraction buffers for ... Also included is a storage buffer ...
Biology Products: