Navigation Links
Scientists use gene transfer technology and common virus to block neuropathic pain

ee of pain the animal is feeling.

One week after surgery, some of the rats received injections of the HSV vector with GAD, while control rats did not receive the vector. Rats given the transgene vector had significantly lower pain threshold responses to filament touch and heat exposure tests than rats that did not receive the vector.

"We saw a sustained, continuous pain-suppressing effect that began one week after inoculation with the vector and lasted for six weeks," says Marina Mata, M.D., staff neurologist at the VA Ann Arbor Healthcare System, professor of neurology in the U-M Medical School and co-director of the research team. "By seven weeks after inoculation, the pain-blocking effect disappeared, but a second inoculation into the same paw re-established the effect."

In previous research, Mata and Fink have used their HSV vector to deliver other neurotrophic factors and pain-suppressing drugs to spinal ganglion cells. But Fink says the effect of the GAD-expressing vector is substantially greater for neuropathic pain, because it helps correct the reduction of GABA in the spinal cord. He also emphasizes the excellent safety record of the HSV vector, which has produced no side effects or complications in many animal studies.

"I am a clinical neurologist and I see patients with neuropathic pain," Fink says. "These patients suffer tremendously and the treatments available to us now have limited effectiveness. Using our herpes vector to provide targeted gene delivery to the nervous system is a novel approach that shows tremendous promise for the treatment of neuropathic pain."

In future research, the scientists plan to conduct the first phase I safety trial of a related HSV vector in patients with pain caused by terminal cancer, which has spread to bone.


'"/>

Source:University of Michigan Health Systems


Page: 1 2 3 4

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:7/25/2014)... on the land now called California, and many of ... plants they used for food, fuel, tools, and ritual. ... habitat and natural resources. , Frank Lake, an ecologist ... lead a field trip to the Stone ... America,s 99th Annual Meeting, in Sacramento, Cal. this August. ...
(Date:7/25/2014)... A study published online in the International ... novel approach to preventing cervical cancer based on findings ... after removal of a discrete population of cells in ... study that looked at squamocolumnar junction cells, or SCJ ... have been implicated as the origins of cervical cancer. ...
(Date:7/25/2014)... University of Adelaide has opened the way for the development ... , In Australia, annual barley production is second only to ... one of the most important diseases of barley. , Senior ... composition of special growths on the cell walls of barley ... leaf. , The research, by the ARC Centre of Excellence ...
Breaking Biology News(10 mins):Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3Clearing cells to prevent cervical cancer 2New hope for powdery mildew resistant barley 2
... How marine animals find their way back to their birthplace ... ocean has mystified scientists for more than a century. But ... Hill think they might finally have unraveled the secret. ... may read the magnetic field of their home area and ...
... STANFORD, Calif. Scientists around the world may benefit ... that will help them to home in on the ... Arend Sidow, PhD, associate professor of pathology and of ... launched the novel bioinformatics tool, which enlists evolution as ...
... will hold a colloquium to examine what lies ahead ... organisms. Leading researchers and students will discuss new tools ... from the perspectives of ecology, paleontology, phylogenetics, and biodiversity ... the Sackler Colloquium series, the event will take place ...
Cached Biology News:No place like home: New theory for how salmon, sea turtles find their birthplace 2No place like home: New theory for how salmon, sea turtles find their birthplace 3Powerful online tool for protein analysis provided pro bono by Stanford geneticist 2Powerful online tool for protein analysis provided pro bono by Stanford geneticist 3
(Date:7/24/2014)... 2014  Asterias Biotherapeutics, Inc. (OTCBB: ASTYV), a ... regenerative medicine, announced today that it will host ... on Tuesday, July 29, 2014, at 4:30 p.m. ... an overview of Asterias, business strategy and product ... http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 minutes before the ...
(Date:7/24/2014)... computers have yet to materialise. Yet, scientists are ... such computers faster. One such approach relies on ... by applying an electric field. A new study ... coupled quantum dots (TQDs) with electrical impulses can ... example, should TQDs be used as quantum information ...
(Date:7/24/2014)... Research and Markets has announced the addition ... Market 2014-2018" report to their offering. ... the study of the gene and its functions and ... of proteomes or sets of proteins by using molecular ... mapping of genes and DNA sequencing to understand the ...
(Date:7/24/2014)... CA (PRWEB) July 24, 2014 Three ... be semi-finalists in Livestrong’s Big C Competition. Out of ... are each headed to the semi-final round. In this ... exclusive three-month accelerator program, complete with mentoring from thought-leaders ... , As part of the angelMD commitment to the ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... CAMBRIDGE, Mass., Feb. 6 Idenix,Pharmaceuticals, Inc. (Nasdaq: ... corporate overview at the upcoming BIO CEO & Investor,Conference ... in the Park Avenue,Suite Center/North Room at the Waldorf-Astoria ... archived webcasts of the presentation can be accessed,under "Calendar ...
... YORK, Feb. 6 Over the past few ... has become increasingly,apparent. Multinational interest and investment in ... and competition is heating,up. On one hand big ... offshoring. On the other hand, drug safety issues, ...
... Feb. 6 /PRNewswire-FirstCall/ - Diagnostic Imaging,International Corp. (OTCBB: DIIG) ... has been cleared for quotation on the OTC Bulletin,Board., ... Company announced today that the corporate website is,now live ... work diligently to build on its business plan as,quickly ...
Cached Biology Technology:Contract Services for Big Pharma and Biotechs Driving Growth and Innovation from Discovery to Clinical Trials 2Diagnostic Imaging - New Stock Symbol - OTCBB: DIIG 2
... complete ready-to-use reagents for the isolation of ... formulated for the isolation of genomic DNA ... formulated for the isolation of genomic DNA ... Reagents can be used for restriction endonuclease ...
Detects activated caspases in living cells. Simple/sensitive/straight-forward procedure takes only 30 minutes. Results can be analyzed by flow cytometry/fluorescence microscopy/fluorescence plate rea...
Apoptosis Detection Systems and Reagents...
Apoptosis Detection Systems and Reagents...
Biology Products: