Navigation Links
Scientists unravel clue in cortisol production

When a person's under stress or injured, the adrenal gland releases cortisol to help restore the body's functions to normal. But the hormone's effects are many and varied, lowering the activity of the immune system, helping create memories with short-term exposure, while impairing learning if there's too much for too long. Given the variety of its effects,understanding how cortisol is made is essential to producing medications that can alter its production.

Scientists at the Georgia Institute of Technology have discovered an important step in cortisol production, finding that although the output of the hormone is continuous, the molecular production is cyclic in nature ?involving a rhythmic binding and unbinding of a protein essential to its production. The research, which increases understanding of how the brain and the endocrine system work together to regulate health, appears in the February issue of the journal Molecular Endocrinology.

Turning cholesterol into the stress hormone cortisol involves many reactions and begins when the hypothalamus sends a signal to the adrenal glands. Proteins then flood into the nucleus to bind to the DNA, creating the gene CYP 17. What happens next is well understood; CYP 17, along with a battery of other enzymes, transforms cholesterol into cortisol. But what isn't understood is how this protein binding creates CYP 17, or which proteins are important. So, graduate students Eric Dammer and Adam Leon, along with Marion Sewer, assistant professor in Georgia Tech's School of Biology, decided to model the events that occur after the adrenal gland receives the signal.

One of the things the signal does is cause adrenal cells to increase their production of cyclic AMP (cAMP), a chemical that encourages proteins to interact. So they began by causing the cells to make more cAMP. Then as the proteins assembled on the DNA, they tested the cells at different intervals in order to get a snapshot of which proteins wer
'"/>

Source:Georgia Institute of Technology


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists unravel clue cortisol production

(Date:7/24/2014)... For years, researchers and patients have hoped that ... type in the bodycould provide insight into numerous diseases ... has been hampered by the inability to transfer research ... counterparts, in part because human ESCs are "primed" and ... Thorold Theunissen, Benjamin Powell, and Haoyi Wang, who are ...
(Date:7/24/2014)... conducting research into the potato genes that best adapt ... reduction in rainfall and increased extremes of hot and ... genes in order to create new potato varieties that ... also seeking to find out how the current potato ... and higher and lower temperatures. , This research is ...
(Date:7/24/2014)... of researchers led by the University of York has ... in the Western Indian Ocean. , The results, ... to a revolution in the management of marine protected ... than 11,000 km in the region now under ... zones of the seas and coasts designed to protect ...
Breaking Biology News(10 mins):Whitehead Institute researchers create 'naïve' pluripotent human embryonic stem cells 2Neiker-Tecnalia is researching the potato genes that best adapt to climate change 2Western Indian Ocean communities play vital role in conservation 2
... The last decade has seen a dramatic decline ... public health crisis across the world. A new ... patients a potential new approach toward the creation of ... become more resistant to our current classes of antibiotics, ...
... CLEVELAND Sediment in rivers comes from erosion of the ... banks themselves. Just how much each source contributes to a ... of that river is the subject of research by ... University. Taking measure of certain radionuclides found in the ...
... - When a reactor in the Chernobyl nuclear power ... Soviet republic of Ukraine, radioactive elements were released in ... and even eastern portions of North America. , ... Reserve University traveled to Sweden and Poland to gain ...
Cached Biology News:Groundbreaking discovery may lead to stronger antibiotics 2Case Western Reserve University project ties soil conservation and river management together 2Case Western Reserve University researchers track Chernobyl fallout 2
(Date:7/24/2014)... 2014   Cypher Genomics, Inc., the ... Adam Simpson as president and chief ... comprehensive annotation and interpretation of individual human genomes ... "Cypher,s technology has the potential to play a ... accuracy, optimizing therapeutic approaches and reducing adverse drug ...
(Date:7/24/2014)... The patent provides substantially greater ... results. It also enables true sample ID and ... reporting of high profile assays such as those ... growing area of biotechnology that includes DNA based ... companion diagnostics in personalized medicine. The new patent ...
(Date:7/23/2014)... Ras Al Khaimah, United Arab Emirates (UAE) (PRWEB) July ... equity firm Grace Century recently announced that ... Dr. Jim Vaught , Ph.D. to its growing ... Century said, “We are very pleased to have Dr. ... along with the scientific depth and expertise that Provia’s ...
(Date:7/23/2014)... efforts have made great strides in saving China,s endangered ... are over 65 giant panda reserves that have been ... efforts, just 1596 pandas remain in the wild. ... to save the panda by improving genetic diversity, avoid ... Just how are these high-profile programs doing so far? ...
Breaking Biology Technology:Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3New DNA-barcode Patent Virtually Eliminates False Test Results and Sample Mix-up 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 3Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 4
... for some time that the hormone leptin acts in the ... remained a mystery. Now, new research published by Cell Press ... reveals neurobiological mechanisms that may underlie the antiobesity effects ... by fat cells and acts at its receptor in the ...
... clot-forming platelets every day, but there are times when ... diseases or during invasive surgery. Now, University of Pennsylvania ... bone marrow cells called megakaryocytes to quadruple the number ... student of pharmacology in Penn,s Perelman School of Medicine, ...
... carbon nanotubes, developed by MIT researchers, shows promise as an ... needed. Storing the sun,s heat in chemical form ... itself in a heavily insulated container has significant advantages, ... long periods of time without losing any of its stored ...
Cached Biology Technology:Modulation of inhibitory output is key function of antiobesity hormone 2Penn researchers show single drug and soft environment can increase platelet production 2Penn researchers show single drug and soft environment can increase platelet production 3MIT research update: New way to store sun's heat 2MIT research update: New way to store sun's heat 3
... The Varian 500-MS LC Ion ... for high-throughput LC/MS analysis where sensitivity, ... Varian 500-MS provides a robust platform ... sensitivity, mass resolution, and mass stability ...
... ejector is a unique product that facilitates ... their holder. Linkage: This CLS number is ... match Cornings product number. If showing no ... Sigma-Aldrich number (Z71,314-7) or contact customer service ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
... These versatile enclosures ... with nitrogen or other ... a low-humidity environment. HEPA ... and ionization modules also ...
Biology Products: