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Scientists solve 30-year-old mystery of mutant mouse's kidney woes

bsorb water, he says, that results in up to 30 times more urine being dumped into the downstream pipes.

"Eventually, you overwhelm the plumbing system, and it gets backed up to an upstream location: the kidney," Chen says.

Chen plans follow-up studies of aqp2 to determine how important various parts of the protein are to its proper distribution in the kidney collecting duct epithelium. His lab also is looking for other genetic factors that contribute to renal diseases.


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Source:Washington University School of Medicine


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