Navigation Links
Scientists seek to unwrap the sweet mystery of the sugar coat on bacteria

Scientists at The University of Texas at Austin have developed a quick and simple way to investigate the sugar coating that surrounds bacteria and plays a role in infection and immunity.

The sugars coating bacteria can change very quickly during the course of an infection, cloaking the bacteria from the immune system of their host. Previous techniques for studying the sugars were too slow to catch these rapid changes.

"There's a growing recognition of the importance of carbohydrates on bacterial cell surfaces," says Dr. Lara Mahal, lead researcher and assistant professor of chemistry and biochemistry with the Institute for Cellular and Molecular Biology. "The carbohydrate coating is critical in how your immune system recognizes bacteria."

Mahal and graduate student Ken Hsu report their findings in the advance on-line edition and March issue of Nature Chemical Biology.

The scientists studied the sugar coats of four strains of bacteria: two lab strains of E. coli, one pathogenic strain of E. coli that causes neonatal meningitis, and Salmonella typhimurium, which causes food poisoning.

They analyzed each strain of bacteria using lectin microarrays--small glass plates covered with dots of sugar-binding proteins called lectins. The lectin dots act like microbe Velcro. Bacteria with a surface sugar that matches a specific lectin stick to that lectin dot. Because the bacteria are fluorescently labeled, Mahal and her colleagues can read the patterns of glowing dots and determine which sugars coat the bacteria.

The microarray technique worked fast enough that the researchers were able to see the sugar coating change over time in the neonatal meningitis strain of E. coli.

"Over time, the lectins lost their ability to see these bacteria," says Mahal. "This demonstrates that our system is able to see a dynamic change in the carbohydrates on bacteria surface over time."

Mahal says the microarray method could prov
'"/>

Source:University of Texas at Austin


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists seek unwrap the sweet mystery the sugar coat bacteria

(Date:7/21/2015)... , July 21, 2015 Passwords have ... seen in the recent U.S. Office of Personnel ... to the infosec conundrum, but developers and end-users ... To address this dilemma, Biometrics-as-a-Service provider HYPR Corp. ... Tokenization SDK for third party integration. ...
(Date:7/9/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/98rrmr/biometrics_for ... "Biometrics for Banking; Market & Technology Analysis, Adoption ... offering. The adoption for banking purposes ... the forecast is that by 2020 it will ... in delivering biometric systems to the banking industry. ...
(Date:7/8/2015)... , July 8, 2015  Trovagene, Inc. ... molecular diagnostics, today announced the launch of a ... Company,s Precision Cancer Monitoring℠ (PCM) technology for predicting ... one or a combination of the novel immunotherapy ... (nivolumab), a PD-1 inhibitor. The 50-patient study will ...
Breaking Biology News(10 mins):HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4
... food could be made healthier by adding an extract of ... The highly-fibrous seaweed extract, alginate, could be used to increase ... food which usually contain large amounts of fat and a ... at the University of Newcastle upon Tyne publish their findings ...
... Although more than 3 billion doses of the BCG vaccine ... BCG vaccine to protect adults is very limited, as is ... appearing online on August 18 in advance of print publication ... Investigation, Stefan Kaufmann and colleagues from the Max Planck Institute ...
... Testing for drug resistance in HIV-infected patients at the ... patients' life expectancy, according to an article in the ... online. , Resistance to antiretroviral therapy, even in ... concern. However, genotype resistance testing, which involves looking for ...
Cached Biology News:Seaweed could make junk food healthier 2Drug resistance testing in treatment-naive HIV patients is cost-effective 2
(Date:7/29/2015)... 29, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ) ... Chief Financial Officer has resigned.  The Company has hired ... who retired in December 2014, as full time interim ... successor.     Andy Ashworth began his ... a smooth transition.  Andy was the Company,s CFO from ...
(Date:7/29/2015)... ... July 29, 2015 , ... Brady (NYSE:BRC), a ... Label Guide . To align chemical container labeling with OSHA’s updated Hazard Communication ... label components, an example of an accurate label, and pictogram uses and meanings. ...
(Date:7/29/2015)... ... July 29, 2015 , ... The third Medical Innovation Impact ... products , in particular, drug/device combinations. The current system received a score of 0 ... for Patient Centered Innovation (iPCI) of Fairleigh Dickinson University’s ( FDU ) Rothman ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... introduces CHRONO NIGHT Express Contouring Bi-Gel, a nighttime-specific product that targets fat cells ... sugars that are able to enter fat cells, inhibiting the formation of new ...
Breaking Biology Technology:BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3Brady Announces a New GHS Label Guide 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3
... NEW YORK, Jan. 16 With the field ... research, the Society for Biological Engineering,(SBE) has organized ... conference, which runs from January 20th to 23rd ... will focus on,engineering designs for stem cell production, ...
... Today Top Institute,Pharma announces a highly promising ... a malaria vaccine. This TI Pharma project will ... The project aims to,develop a highly protective malaria ... people in developing countries, especially infants and,children. No ...
... 16 Start Licensing, Inc.,("Start"), a joint venture ... the final risk assessment released by the US ... concluded that meat and,dairy products from animal clones ... "FDA,s conclusion is consistent with a report released ...
Cached Biology Technology:Society for Biological Engineering Holds First International Conference on Stem Cell Engineering 2Boost for Malaria Vaccine Development by Combining Strengths of Dutch and American Researchers 2Boost for Malaria Vaccine Development by Combining Strengths of Dutch and American Researchers 3Boost for Malaria Vaccine Development by Combining Strengths of Dutch and American Researchers 4
... provide automated, higher throughput screening of 96-well ... This flexible sample format makes the Guava ... research, target validation, assay development, and even ... Guava PCA-96 uses a green laser detection ...
... delivers a novel procedure for the uniform ... whole genome DNA from small samples. This ... quick and highly reproducible amplification and labeling ... a REPLI-g Mini Kit module (QIAGEN) and ...
... The Cellomics KineticScan™ Reader is ... "Smart Solutions for Cell-based Screening". ... the ability to do both ... of physiological processes, dynamic distribution ...
... Introduction of a protein into cells permits ... signaling pathways, apoptotic pathways, and transcription factor-mediated ... studying the effects of a specific protein ... the protein directly into the cell. ProteoJuice ...
Biology Products: