Navigation Links
Scientists reveal structure of gateways to gene control

Scientists at Penn State University will reveal in the 29 March 2007 issue of the journal Nature the first complete high-resolution map of important structures that control how genes are packaged and regulated throughout an entire genome. "For the first time, we are seeing in very high resolution on a genome-wide scale how nucleosomes control the expression of an organism's genes," said B. Franklin Pugh, professor of biochemistry and molecular biology and the study's lead investigator.

The map pinpoints the locations of certain key gene-controlling nucleosomes -- spool-like structures that wrap short regions of DNA around a protein core. The research suggests how these nucleosomes, positioned at important transcription-promoter sites throughout the cell's DNA, control whether or not a gene's function can be turned on in a particular cell.

The study's many surprising findings together reveal an intimate relationship between the architecture of nucleosome structures and the underlying DNA sequences they regulate. "We now know exactly where these nucleosomes are positioned on the DNA molecule and which DNA building blocks they have wrapped up under their tight control," Pugh said. Among those building blocks, Pugh and his colleagues revealed the architecture of a critical gateway, controlled by the nucleosome, which must be unlocked before a gene can be transcribed.

The study revealed that almost all genes have the same kind of structure where transcription begins, that this beginning contains a critical gateway for transcription, and that the transcription gateway of each gene almost always is located at the same place on a nucleosome. The researchers also discovered some genes whose pattern is somewhat different from this norm, and these unusual sequences also are reported in the Nature paper. "We previously had a low-resolution idea that these structures all could be roughly in the same position, but now this high-resolution map mak
'"/>

Source:Penn State


Page: 1 2 3 4

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists reveal structure gateways gene control

(Date:8/21/2014)... digesting itself resulting in severe abdominal pain, vomiting and ... patients are diagnosed with the disease resulting in 1000 ... restricted to intravenous fluid and nutritional support. , ... who led the research, said "The major causes of ... excessive alcohol intake combined with a high fat diet. ...
(Date:8/20/2014)... study of 158 pregnant teenagers in Rochester, NY, nearly ... consumption of ice, cornstarch, vacuum dust, baby powder and ... study. , Moreover, such teens had significantly lower iron ... nonfood substances. , Pregnant teens, regardless of pica, are ... to iron deficiency and anemia. Low iron in pregnant ...
(Date:8/20/2014)... finds life can persist in a cold, dark world. ... team that examined waters and sediments from a shallow ... the extreme environment supports microbial ecosystems. , The ... colleagues has implications for life in other extreme environments, ... findings are published in the current edition of the ...
Breaking Biology News(10 mins):Insulin offers new hope for the treatment of acute pancreatitis 2Pica in pregnant teens linked to low iron 2University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2
... taking advantage of improvements in satellite sensor capabilities offer ... from East Asian forest fires, urban exhaust, and industrial ... China, the worlds most populated country, has experienced ... and considerable expansion in automobile use over the last ...
... their brief dominance in a primitive North America, deserve ... New evidence says it took thousands of years for ... six scientists, including Jon M. Erlandson of the University ... the National Academy of Sciences (online, March 13) after ...
... 17, 2008) Take a deers body, attach a camels head ... the odd-ball antelope with the enormous schnoz that lives on ... endangered as they are strange-looking due to over-hunting. Now, according ... in jeopardy as well. ...
Cached Biology News:NASA satellite measures pollution from east Asia to North America 2NASA satellite measures pollution from east Asia to North America 3Clovis-age overkill didn't take out California's flightless sea duck 2Asia's odd-ball antelope faces migration crisis 2
(Date:8/21/2014)... His Majesty Willem-Alexander, King of the Netherlands to ... Majesty Willem-Alexander, King of the Netherlands, has announced that ... Advanced Biofuels’ Project LIBERTY cellulosic ethanol plant in Emmetsburg, ... take part in the Grand Opening Ceremony to perform ... and tour the plant. POET-DSM is a joint venture ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... in Brazil and ... restrictions. The uptake of several newly approved agents, ... for this indication and the launch of emerging ... asthma markets. In particular, the emerging IL-5 inhibitors ...
(Date:8/21/2014)... Aug. 21, 2014  China Cord Blood Corporation (NYSE: ... to release financial results for the first quarter of ... market close in the US.  The ... ET on Friday, August 29, 2014 to discuss its ... Company,s recent developments, followed by a question and answer ...
(Date:8/21/2014)... Ontotext S4 , The Self Service Semantic ... Now the same enterprise hardened text mining, Linked Data ... is available to start-ups and mid-size businesses at a ... do not have resources to evaluate and prototype enterprise ... there is no need for on premise hardware provisioning ...
Breaking Biology Technology:His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
... , ,Your business card reads project manager. You just ... training, regularly participate in seminars and sleep with scholarly ... desk is almost worn out; yellow sticky notes mark ... control section by heart! Youd rather have Gantt charts ...
... Entrepreneurs Conference got off to a dynamic start on Tuesday ... hundred entrepreneurs and industry representatives to a crash course in ... camp was designed serve both veteran and novice business owners, ... of seasoned industrialists. , ,Our purpose is to focus on ...
... emerged as a new leading security solution that combines ... holistic and efficient approach to security. It is a ... , ,Most security imperatives from an IT perspective have ... host of similar components of network security. But more ...
Cached Biology Technology:Part 5 Project Performance Get on the path to continuous improvement 2Part 5 Project Performance Get on the path to continuous improvement 3Part 5 Project Performance Get on the path to continuous improvement 4Entrepreneurs get crash course for building a successful company 2Entrepreneurs get crash course for building a successful company 3IP Surveillance - Another Piece of the Converged Network 2IP Surveillance - Another Piece of the Converged Network 3
... Pro-mix l-[35S]in vitro cell labeling ... *Aqueous solution stabilized with ... mM pyridine 3,4-dicarboxylic acid. *Amino ... protein labeling containing l-[35S]Methionine and ...
... Assay, 96 wells. ELISA.Specific for total ... MMP-3. No cross-reactivity with MMP-1, -2, -9. ... use with cell culture supernatant, serum, plasma ... to -30 C. Category: Drug Screening ...
... Designed for serial ... protein fractions including cytosol/particulate/cytoskeleton/nuclear ... All these fractions can ... downstream assays such as ...
Self Closing Forceps...
Biology Products: