Navigation Links
Scientists reveal how disease bacterium survives inside immune system cell

New research on a bacterium that can survive encounters with specific immune system cells has strengthened scientists' belief that these plentiful white blood cells, known as neutrophils, dictate whether our immune system will permit or prevent bacterial infections. A paper describing the research was released today online in The Journal of Immunology. Frank R. DeLeo, Ph.D., of Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health, directed the work at RML, in Hamilton, MT, in collaboration with lead author Dori L. Borjesson, D.V.M., Ph.D., of the University of Minnesota in St. Paul.

Scientists analyzed how neutrophils from healthy blood donors respond to Anaplasma phagocytophilum, a tick-borne bacterium that causes granulocytic anaplasmosis in people, dogs, horses and cows. A. phagocytophilum is carried by the same tick that transmits Lyme disease and was first identified in humans in 1996. Human granulocytic anaplasmosis (HGA) -- formerly called human granulocytic ehrlichiosis -- is prevalent in Minnesota and along the East Coast. HGA typically causes mild symptoms that include fever, muscle aches and nausea. Some 362 U.S. cases were reported to the Centers for Disease Control and Prevention in 2003.

HGA is considered an emerging infectious disease, and Dr. Borjesson is working to understand how it affects blood cells -- and neutrophils in particular. "Few people know about this pathogen, but it is important because it is transmitted by ticks and causes disease in both animals and humans," Dr. Borjesson says.

Neutrophils, which make up about 60 percent of all white blood cells, are the largest cellular component of the human immune system -- billions exist inside each human. Typically, neutrophils ingest and then kill harmful bacteria by producing molecules that are toxic to cells, including a bleach-like substance called hypochlorous acid. Once the b
'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:8/19/2014)... lemur. It,s not an African Bush Baby or even a ... downright "cool" primate from Southeast Asia. , "It,s really not ... Brown, curator-in-charge at the University of Kansas, Biodiversity Institute. "A ... body; a long tail with a furry tuft at the ... a bit like the disks on the digits of tree ...
(Date:8/19/2014)... New measurements from fish purchased at retail seafood ... to which mislabeling can expose consumers to unexpectedly ... Fishery stock "substitutions"which falsely present a fish of ... originare the most dangerous mislabeling offense, according to ... scientists. , "Accurate labeling of seafood is essential ...
(Date:8/19/2014)... have identified a biomarker strongly associated with basal-like ... resistant to many types of chemotherapy. The biomarker, ... for new therapeutics designed to treat this often ... taken from The Cancer Genome Atlas, molecular biologists ... powerful computational and bioinformatics techniques to detect patterns ...
Breaking Biology News(10 mins):Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3
... Consumers shouldn,t assume that, because a product is ... University of Guelph study reveals some organic pesticides ... pesticides because the organic product may require larger ... PhD candidate Christine Bahlai compared the effectiveness and ...
... that governs flower formation has been uncovered in the daisy-like ... BMC Plant Biology have published a pair of articles ... this process differs from other model plants, such as the ... Teeri, from the University of Helsinki, Finland, worked with a ...
... been puzzled by the ability of microscopic algae to grow ... essential algal nutrient. In this week,s issue of Nature, ... Riser at the University of Washington and David Karl at ... from deep water, as much as 250 meters below the ...
Cached Biology News:Organic pesticides not always 'greener' choice, study finds 2Researchers discover source of essential nutrients for mid-ocean algae 2Researchers discover source of essential nutrients for mid-ocean algae 3
(Date:8/20/2014)... licensed to biotechnology firms has revealed early bottlenecks ... roadblocks, the researchers suggest that better communication of ... lead to faster commercialization down the road. , ... in university laboratories and licensed to biotechnology firms. ... have a high failure rate. But a new ...
(Date:8/20/2014)... , Aug. 20, 2014  Decision Resources Group finds that the ... Russia , India and ... in 2013, roughly equal to the size of the ... BRIC market will experience much faster growth as a result of ... Other key findings from Decision Resources Group,s coverage of ...
(Date:8/20/2014)... could improve the health of your heart, researchers have ... used a standard TENS machine like those designed to ... tragus, the small raised flap at the front of ... , The stimulation changed the influence of the nervous ... that can drive failing hearts too hard. , Professor ...
(Date:8/19/2014)... DUBLIN , Aug. 19, 2014 Research and ... Culture Supplies - Global Strategic Business Report" report to their ... Cell and Tissue Culture Supplies in US$ Thousands by the following ... separate comprehensive analytics for the US, Canada , ... Asia-Pacific , and Latin America . ...
Breaking Biology Technology:Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3'Tickling' your ear could be good for your heart 2Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2
... June 22 Globally, the largest market for bio-diesel is the ... emissions by 8.0 percent between 2008 and 2012 has resulted in ... transportation fuel by December 2010 and 10 percent by 2020. Though ... growth in terms of both new bio-diesel capacities coming on-stream as ...
... Americans United for Life (AUL) criticized President ... replace it with a new bioethics commission having a mandate to ... Bioethics was created in November 2001 by President Bush after his ... while limiting the research to existing cell lines. , , ...
... BEIJING, June 19 /PRNewswire-Asia/ -- Sinovac Biotech Ltd.,(NYSE ... of vaccines in China,announced today that the Company received the ... to the Beijing government. The initial order,consists of 4 million ... of,September. This order will be administered to 2 million ...
Cached Biology Technology:Government Mandates Create Guaranteed Market for Bio-Fuel, Says Frost & Sullivan 2Government Mandates Create Guaranteed Market for Bio-Fuel, Says Frost & Sullivan 3Government Mandates Create Guaranteed Market for Bio-Fuel, Says Frost & Sullivan 4Americans United for Life: Obama's Disbanding Bioethics Council Raises Troubling Questions 2Sinovac Receives China's First Influenza A (H1N1) Vaccine Order 2Sinovac Receives China's First Influenza A (H1N1) Vaccine Order 3