Navigation Links
Scientists pinpoint inflammation gene

ry investigations to discover the function of the SEPS1 gene and this particular variant.

"These experiments showed that this genetic variation affects how the cell responds to stress," Curran said. "The more common variant the one most people have is the 'good form' of SEPS1 that is more efficient at perceiving and responding to cellular stress. The alternative, rarer variant weakens SEPS1 and puts it at a disadvantage in dealing with cellular stress."

Blangero explained, "Basically, this rarer form of SEPS1 gives you a lazy cellular 'garbage truck' that doesn't properly do its job of clearing out the misfolded proteins that lead to inflammation."

As further confirmation of their study results with the Wisconsin population, the researchers looked to see if they would replicate their findings in a distinct group of Texas families. A team of SFBR scientists led by Dr. Jean MacCluer is conducting a long-term, National Institutes of Health-sponsored study on the genetics of heart disease, diabetes and obesity in 1,400 Mexican Americans from 90 San Antonio families.

Researchers studied an additional 500 individuals from 20 families of this San Antonio Family Heart Study and performed the same genetic analysis that was previously done with the Wisconsin families. "Once again, we obtained the same results," said Blangero. "We replicated our findings in another study with a different population of a different ethnic group, which is rare in human genetics. This adds to other clear evidence that SEPS1 is a good target in defeating inflammation, which plays an important role in virtually every disease of major public health importance."


'"/>

Source:Medical College of Wisconsin


Page: 1 2 3 4

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists pinpoint inflammation gene

(Date:5/8/2015)... Calif. , May 8, 2015 Synaptics Inc. ... solutions, today announced that members of the executive management team ... Morgan 43rd Annual Technology, Media and Telecom Conference Date: ... Hotel in Boston, MA ... 27, 2015 Time: 2:45pm ET Location: The New York Palace ...
(Date:4/27/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces that its ... the first week of May, 2015 and will be ... Gino Pereira , Chief Executive ... company as Wocket® enters the consumer market. We would ...
(Date:4/17/2015)... 2015 Increasing adoption ... advancement to drive biometric systems market in ... According to a recently released TechSci ... ", biometric systems market in Saudi ... at CAGR of over 22% through 2020. The ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... Washington, D.C. (October 5, 2010) -- Carbon nanotubes -- ... in diameter -- have many potential uses in nanotechnology, ... of nanotubes depend on their structure, and scientists as ... determined during the initial formation -- or growth -- ...
... BOZEMAN, Mont. -- Montana State University researchers have discovered a ... geothermal vents at the bottom of Yellowstone Lake. A ... in an area where the water is inky black, about ... poisons, the researchers reported in the September issue of Geobiology. ...
... toxic pollution falling onto Puget Sound,s waters has decreased ... below earlier estimates, according to a region-wide study. Despite ... like Tacoma still have the Puget,s Sound,s highest air-deposited ... of Energy,s Pacific Northwest National Laboratory and Texas A&M ...
Cached Biology News:The effects of hydrogen on growing carbon nanotubes 2Montana State team finds rare oasis of life on floor of Yellowstone Lake 2Montana State team finds rare oasis of life on floor of Yellowstone Lake 3Montana State team finds rare oasis of life on floor of Yellowstone Lake 4The sky is falling (less) onto Puget Sound 2The sky is falling (less) onto Puget Sound 3The sky is falling (less) onto Puget Sound 4
(Date:5/28/2015)... MA (PRWEB) May 28, 2015 In ... director, James L. Sherley, M.D., Ph.D., will present the ... medicine. In a conference talk, he will describe ... cell culture designs with computer simulation to produce the ... cell number and quality over time in culture. ...
(Date:5/27/2015)... May 27, 2015 RXi Pharmaceuticals Corporation ... on discovering and developing innovative therapies primarily in ... it has commenced a public offering of shares ... of its common stock and overallotment purchase rights ... shares of common stock, warrants and overallotment purchase ...
(Date:5/27/2015)... The Academy of Model Aeronautics Foundation would like ... Aviation Day. The third annual celebration will be August 15, ... model aviation hobby nation-wide and to introduce model flying to ... chartered clubs to celebrate the hobby and share it with ... will also be a local event at the AMA headquarters ...
(Date:5/27/2015)... May 27, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) ... 31, 2015. Aviv Boim , ... pre-clinical work to generate functional specific antibodies, targeting identified ... we are encouraged by the development progress. We are ... antibodies which modulate immune checkpoints gain clinical acceptance for ...
Breaking Biology Technology:Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 3RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 3Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 2Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 3Tikcro Technologies Reports First Quarter 2015 Results 2Tikcro Technologies Reports First Quarter 2015 Results 3
... OREX ), a biopharmaceutical company focused on ... Patent and Trademark Office,(USPTO) has issued a patent for ... (U.S. Patent No. 7,462,626), which provides,coverage for Contrave(R), the ... trials. , The patent broadly ...
... BELGIUM, Wis., Jan. 5 Mach One Corporation,(Pink Sheets: ... a positive long term benefit to the agricultural and ... non-binding letter of,intent dated December 30, 2008 related to ... BioPharm) (the "Seller" or "BioPharm") to,acquire all of the ...
... of Norton & Associates with Divisions in NORTECH ... Carbon Credit Today. The group,s announcement of a ... private equity land investments and the acquisition funding ... commercial market conditions, Norton & Associates Inc. provides ...
Cached Biology Technology:Orexigen(R) Therapeutics Issued a Key Fourth U.S. Patent on Contrave(R) 2Orexigen(R) Therapeutics Issued a Key Fourth U.S. Patent on Contrave(R) 3Mach One Corporation Enters Letter of Intent 2Norton & Associates Inc. Adds $3bnUSD Commercial Real Estate Investment P & L Management Holding Group; US Property Portfolio Inc. 2
... High Throughput Processing of Microarrays Using ... ,FAST Frame multiple slide plate is designed ... the corresponding multi-well incubation chambers in a ... microarrays. The footprint dimensions meet the standards ...
... ProXPRESS 2D Proteomic Imaging System, Professional Package ... a Wide Dynamic Range: The ProXPRESS 2D ... in imaging system for both proteomic and ... provides unparalleled flexibility, enabling the use of ...
... Blot includes 7 ... isolated from Alzheimer's-diseased brain ... postcentral gyrus, frontal lobe, ... occipital lobe and cerebellum. ...
... Progenitors, Rabbit, and media. Cryo-preserved cells in ... at passage 25 (approx), supplied with kit ... is supplied as a long-term culture, and ... months of continuous growth from the date ...
Biology Products: