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Scientists map key landmarks in human genome

al normal human cell types. A critical component of the analysis involved processing the data using computational algorithms devised by Dana-Farber faculty member X. Shirley Liu, PhD, and her postdoctoral fellow Jun S. Song, PhD, working closely with Fisher's graduate student Fatih Ozsolak. The researchers borrowed a computational technique from signal processing called "wavelet denoising" that revealed the striking patterns of positioned nucleosomes.

On a graph, the data displayed as a series of peaks and troughs corresponding to positioned nucleosomes and nucleosome-free regions, respectively. Analysis revealed that promoters of genes that had similar expression status (they were all "off" or "on") had related nucleosome locations. The technique successfully pinpointed the location of some nucleosomes previously found through other means, but the new method can be applied to the entire genomes of human and other cells, said the scientists.

In the future, the techniques might be useful as a diagnostic tool, Fisher said.

"Gene expression is important in all diseases," he explained. "And this method offers a new perspective for looking at how gene expression has been altered in human diseases."
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Source:Dana-Farber Cancer Institute


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