Navigation Links
Scientists map key landmarks in human genome

Dana-Farber Cancer Institute researchers have developed a powerful method for charting the positions of key gene-regulating molecules called nucleosomes throughout the human genome. The mapping tool could help uncover important clues for understanding and diagnosing cancer and other diseases, the scientists say. Moreover, it may shed light on the role of nucleosomes in the process of "reprogramming" an adult cell to its original embryonic state, which is a critical operation in cloning.

David E. Fisher, MD, PhD, and his Dana-Farber colleagues describe their findings in Nature Biotechnology, which has published the paper as an advanced online publication on its Web site, www.nature.com/nbt/journal/vaop/ncurrent/index.html.

"This study presents the first global view of human nucleosome positioning," said Fisher. Although analyses of this type had been pioneered in simpler organisms such as yeast, those approaches were not feasible when applied to the massively larger and more complex human genome.

The new technique "provides major new clues to the locations of many hallmark features of the human genome, such as where transcription factors bind, where transcription begins and possibly ends, and where there are other biologically important structural features," said Fisher. Transcription factors are proteins that bind to particular DNA sites in "promoter" regions of genes and turn the genes on or off.

The novel method employed gene microarray studies followed by sophisticated computational data analysis to pin down the nucleosome locations. The paper describes how the scientists used the technique to locate nucleosomes in 3,692 promoters (regions of DNA that interact with regulatory factors to control gene activity) within seven human cell lines, including malignant melanoma.

Nucleosomes are spherical packing units for DNA. They consist of a length of
'"/>

Source:Dana-Farber Cancer Institute


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists map key landmarks human genome

(Date:10/14/2014)... ATHENS, Ohio (Oct. 14, 2014)—It,s been millions of years ... but a team led by Ohio University scientists is ... to model airflow through dinosaur snouts. The research has ... not only breathe but to enhance the sense of ... pretty ,nosy, animals," said Ohio University doctoral student Jason ...
(Date:10/14/2014)... 14, 2014 – High doses of fish oil supplements, rich ... common type of irregular heartbeat in which the heart can ... of the AFFORD trial led by the Montreal Heart Institute ... of Cardiology on October 7th. , For the trial, ... were randomly assigned to 4 grams of fish oil a ...
(Date:10/14/2014)... likely takes between 10 and 20 years to ... window" of intervention if detected early, which may ... say Australian clinical researchers. , Dr Jeremy ... Institute of Medical Research, analysed medical histories and ... pancreatic cancer patients, operated on between 1994 and ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Early detection window when pancreatic cancer is in the family 2
... Researchers from the University of Southampton and the Australian National ... been fast by natural standards and at current rates ... and 2.5 metres by 2200. The team used ... a background pattern of natural sea-level rise. This was compared ...
... dependence on the global food market. The Australian capital ... in its regional hinterland, while Tokyo primarily ensures its ... than half of the consumption of the most common ... food systems of capital cities, an essential insight for ...
... University of Utah Health Sciences faculty members whose ... patents, biomedical inventions, and startup companies have been ... (NAI). Carl W. Wittwer, M.D., Ph.D., professor ... Lisa Cannon-Albright, Ph.D., professor of internal medicine and ...
Cached Biology News:What the past tells us about modern sea-level rise 2Scientists map food security and self-provision of major cities 2Scientists map food security and self-provision of major cities 3Researchers named to National Academy of Inventors 2Researchers named to National Academy of Inventors 3Researchers named to National Academy of Inventors 4
(Date:10/19/2014)... Oct. 19, 2014 NextCODE Health, which enables clinicians ... in real time, today announced the launch of its new ... , at the American Society of Human Genetics (ASHG) annual ... more, sign up and apply for free beta access, visit ... and benefits can be viewed here . ...
(Date:10/19/2014)... The Asian Orthopedic braces and support systems report ... and forecast of revenue. The Orthopedic braces and support systems ... million by 2018, at a developing CAGR of 4.4% from ... Asian Orthopedic braces and support systems market, to get an ... glimpse of the segmentation of orthopedic braces and support systems ...
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and By ... the global market on the basis of its ... such as the key drivers, current trends and ... 81 Market Data Tables and 29 Figures spread ... Market by Application and by Geography - Trends ...
(Date:10/18/2014)... 2014 The Biomass Power ... five years to 2014. The industry's expansion has been ... credits that encouraged the use of biomass power. Furthermore, ... (RPSs), which require local utilities to generate electricity from ... portfolio. Increased campaigning for green technology also influenced industry ...
Breaking Biology Technology:The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... many great assets for building a thriving high technology climate, ... the University of Wisconsin-Madison . Yet we continue ... have lacked one vital ingredient: venture capital to support the ... to the National Venture Capital Association , Wisconsin, a ...
... days - from removing tattoos to playing music on ... Wisconsin, lasers have been harnessed to an entirely new ... Wisconsin-Madison mechanical engineering professor and laser expert, along with ... adapt a so-called "cold laser machining" technique, primarily used ...
... Chippewa Valley Technical College (CVTC) President Bill ... will begin teaching nanotechnology as early as September 2004 ... and opportunities. , ,Jack Uldrich, nanotechnology author, consultant and ... shift of historic proportions brought on by the manipulation ...
Cached Biology Technology:Wisconsins VC Challenge 2Wisconsins VC Challenge 3Wisconsin Engineers Devise Cutting-Edge Method to Cut Cheese 2Wisconsin Engineers Devise Cutting-Edge Method to Cut Cheese 3Chippewa Valley Embraces Nanotechnology 2
Marmoset plasma and serum - various quantities available...
3'-O-Methylguanosine 5'-Triphosphate, Sodium, 1 umol. Category: Nucleotides & Enzymes & Biochemicals, Nucleotides, Additional Nucleotide Products....
Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
EPH electrode, cathode, 1. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
Biology Products: