Navigation Links
Scientists map key landmarks in human genome

Dana-Farber Cancer Institute researchers have developed a powerful method for charting the positions of key gene-regulating molecules called nucleosomes throughout the human genome. The mapping tool could help uncover important clues for understanding and diagnosing cancer and other diseases, the scientists say. Moreover, it may shed light on the role of nucleosomes in the process of "reprogramming" an adult cell to its original embryonic state, which is a critical operation in cloning.

David E. Fisher, MD, PhD, and his Dana-Farber colleagues describe their findings in Nature Biotechnology, which has published the paper as an advanced online publication on its Web site, www.nature.com/nbt/journal/vaop/ncurrent/index.html.

"This study presents the first global view of human nucleosome positioning," said Fisher. Although analyses of this type had been pioneered in simpler organisms such as yeast, those approaches were not feasible when applied to the massively larger and more complex human genome.

The new technique "provides major new clues to the locations of many hallmark features of the human genome, such as where transcription factors bind, where transcription begins and possibly ends, and where there are other biologically important structural features," said Fisher. Transcription factors are proteins that bind to particular DNA sites in "promoter" regions of genes and turn the genes on or off.

The novel method employed gene microarray studies followed by sophisticated computational data analysis to pin down the nucleosome locations. The paper describes how the scientists used the technique to locate nucleosomes in 3,692 promoters (regions of DNA that interact with regulatory factors to control gene activity) within seven human cell lines, including malignant melanoma.

Nucleosomes are spherical packing units for DNA. They consist of a length of
'"/>

Source:Dana-Farber Cancer Institute


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists map key landmarks human genome

(Date:2/5/2015)... 27, 2015   Marvin Test Solutions ... innovative test solutions for military, aerospace, and ... its TS-323 GENASYS Test Platform ... GENASYS is a high-performance PXI-based system designed ... that require performance functional testing. GENASYS features ...
(Date:2/5/2015)... Research and Markets ( http://www.researchandmarkets.com/research/6lngtl/global_biometrics ... "Global Biometrics Market (2014-2020): Market Forecast By Technologies, ... to their offering. , In ... is anticipated to overtake North America ... spending towards IT security, government biometric based projects ...
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ... A Global Market Overview" report to their offering. ... to ensure that an individual is who she/he is claiming ... use of a person,s unique physical characteristics, such as fingerprint, ...
Breaking Biology News(10 mins):Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3
... are increasingly buying fair trade, vegetarian and ecological products, ... place? In their new book about ethical trade, Gothenburg ... so sure. Although it might help ease people,s bad ... the problem, they say. Instead, fixing the problem will ...
... on Virginia Tech beginning June 24 bringing with them not ... to the Blacksburg area in excess of $2 million. ... largest conferences ever held in Blacksburg with 13 simultaneous sessions ... macromolecules that are having a huge impact on ...
... some people excel whether as world-class athletes, virtuoso ... outstanding performers have unique brain characteristics that make them ... in the journal Cognitive Processing found that ... the Brain Integration Scale, Gibbs,s Socio-moral Reasoning questionnaire, and ...
Cached Biology News:Ethical trade: 'Good intentions go to waste' 2Scientific meeting at Virginia Tech will make more than $2 million economic impact 2Scientific meeting at Virginia Tech will make more than $2 million economic impact 3Research breakthrough: High brain integration underlies winning performances 2Research breakthrough: High brain integration underlies winning performances 3Research breakthrough: High brain integration underlies winning performances 4Research breakthrough: High brain integration underlies winning performances 5
(Date:3/6/2015)... , March 6, 2015   InspireMD, Inc. (NYSE ... protection systems, announced today that it will release its full ... 31, 2014 on Thursday, March 12 th after market ... to review its financial results and business outlook. ... ) or (412) 542-4135 (International) and request the InspireMD call. ...
(Date:3/6/2015)... , March 6, 2015 BioSpecifics Technologies ... developing first in class collagenase-based products marketed as XIAFLEX ... U.S. and XIAPEX ®  in the EU, announced today ... audio webcast at 8:30 a.m. ET on Friday, March ... year 2014 financial results and provide a corporate update. ...
(Date:3/6/2015)... 2015 Die ... der Assistance Publique - Hôpitaux de ... eine französische, gemeinschaftliche, randomisierte Kontrollstudie für die ... Verglichen werden Patienten mit fortgeschrittenem hepatozellulärem Karzinom ... Sorafenib behandelt wurden. Die Ergebnisse werden für ...
(Date:3/5/2015)... March 05, 2015 Plant disease specialists ... summer at the Annual Meeting of The American Phytopathological ... be released online now at APSnet.org/meet . , ... the meeting, to be held August 1-5, 2015 in ... Sessions, Field Trips, Workshops, and committee meetings, all carefully ...
Breaking Biology Technology:InspireMD to Report Financial Results for the Fourth Quarter and Year Ended December 31, 2014 on Thursday, March 12th 2BioSpecifics Technologies Corp. to Host Conference Call to Report Fourth Quarter and Full Year 2014 Financial Results on Friday, March 13, 2015 2Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 2Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 3Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 4Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 5Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 6American Phytopathological Society Announces Annual Meeting Daily Schedule 2
... (Nasdaq: CHBT ) ("China-Biotics," "the Company"), ... development, marketing and,distribution of probiotics products ( http://chn-biotics.com/c4427/ ... present at the upcoming,China Rising Conference hosted by ... 18,2009. , The date, ...
... plc,(LSE: SHP, NASDAQ: SHPGY ) the global specialty biopharmaceutical company,announces results for the three months to March 31, 2009. , ... ... 2009 (1), Product sales ... million +20%, Product sales (excluding ADDERALL XR) ...
... Inc. (Nasdaq: MEDX ) announced today its financial ... loss for the quarter ended March 31, 2009 was $48.6 ... 2008, Medarex,s net income of $103.3 million, or $0.81 per ... share, from the sale of 2.5 million shares of Genmab ...
Cached Biology Technology:China-Biotics, Inc. to Present at CCG Investor Relations' China Rising Conference 2China-Biotics, Inc. to Present at CCG Investor Relations' China Rising Conference 3Shire begins the year with a strong performance 2Shire begins the year with a strong performance 3Shire begins the year with a strong performance 4Shire begins the year with a strong performance 5Shire begins the year with a strong performance 6Shire begins the year with a strong performance 7Shire begins the year with a strong performance 8Shire begins the year with a strong performance 9Shire begins the year with a strong performance 10Shire begins the year with a strong performance 11Shire begins the year with a strong performance 12Shire begins the year with a strong performance 13Shire begins the year with a strong performance 14Shire begins the year with a strong performance 15Shire begins the year with a strong performance 16Shire begins the year with a strong performance 17Shire begins the year with a strong performance 18Shire begins the year with a strong performance 19Shire begins the year with a strong performance 20Shire begins the year with a strong performance 21Shire begins the year with a strong performance 22Shire begins the year with a strong performance 23Shire begins the year with a strong performance 24Shire begins the year with a strong performance 25Shire begins the year with a strong performance 26Shire begins the year with a strong performance 27Shire begins the year with a strong performance 28Shire begins the year with a strong performance 29Shire begins the year with a strong performance 30Shire begins the year with a strong performance 31Shire begins the year with a strong performance 32Shire begins the year with a strong performance 33Medarex Announces 2009 First Quarter Financial Results 2
... has been developed specifically for the stabilization ... HRP Stabilizer prevents the loss of catalytic ... antibody or protein antigen portion of the ... microns., ,Contents: Aqueous, protein-containing diluent and ...
... Magnetic Bead Separation is a powerful tool ... applications. Typical applications are DNA/RNA or protein ... ,This has been fully automated on the ... separator Te-MagS. ,In combination with the ...
... cover slips for in situ hybridization,in ... on glass slides., Constant probe ... not adsorb probes. , Ready-to-use-Hybri-slips do ... , Avoid RNA degradation-Hybri-slips are supplied ...
These 22x40mm rectangular No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 73...
Biology Products: