Navigation Links
Scientists learn the origin of rogue B cells

Doctors have long wondered why, in some people, the immune system turns against parts of the body it is designed to protect, leading to autoimmune disease. Now, researchers at the National Institutes of Health's (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in collaboration with the Oklahoma Medical Research Foundation, have provided some new clues into one likely factor: the early development of immune system cells called B cells.

B cells are formed in the bone marrow and produce antibodies. Antibodies are generated from the cutting and splicing of immunoglobulin genes early in B-cell development, and have the potential to develop strong and highly specific affinity for different pathogens. When an infectious pathogen (a disease-causing agent) enters the body, B cells are activated and release antibodies into the bloodstream to combat the pathogen. When antibodies encounter the pathogen, they bind to it, rendering it incapable of causing further harm. Antibody molecules also serve as receptors on the surface of B cells.

The problem occurs when the random cutting and splicing of immunoglobulin genes results in an antibody that recognizes a component of one's own body. While the body has a built-in mechanism to correct these errant cells, the NIAMS researchers discovered this doesn't always work the way it was intended. "What happens is that, if the body ever produces a cell with a self-reactive antibody molecule, that cell will get arrested in development at the point where it is actually combining and creating an antibody receptor," says Rafael Casellas, Ph.D., an investigator in NIAMS's Genomic Integrity and Immunity Group. Often, rather than killing off the cell, the body edits ?or corrects ?the receptor, like one might edit a paper, he says. In normal circumstances, this new, good receptor replaces the bad one, but what Casellas and Dr. Patrick C. Wilson of the Oklahoma Medical Research Foundation found was
'"/>

Source:NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists learn the origin rogue cells

(Date:9/18/2014)... millions of Americans to undertake jaunts into the countryside each ... longer within a century, according to new research. , Climate ... the United States as summer temperatures linger later into the ... Ecology and Biogeography . For instance, the paper birch ... New Hampshire could change color one to three weeks ...
(Date:9/18/2014)... colleagues have built the first smartphone app that ... behavioral trends. In other words, your smartphone knows ... don,t -- and how that affects you. , ... depression and loneliness to their academic performance, also ... for example, to monitor mental health, trigger intervention ...
(Date:9/18/2014)... seem to be cheerful, happy-go-lucky characters, so you might ... life. , In fact some dogs are distinctly ... Sydney shows. , "This research is exciting because ... objectively and non-invasively. It offers researchers and dog owners ... that changes," said Dr Melissa Starling, from the Faculty ...
Breaking Biology News(10 mins):Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Dogs can be pessimists too 2Dogs can be pessimists too 3
... Mich. A new study finds that African ancestry ... type of cancer that has fewer treatment options. ... found that, among women with breast cancer, 82 percent ... African-Americans were and 16 percent of white Americans were. ...
... crocodiles and navigating around massive submerged trees, a team ... pools of Cara Blanca, Belize, which were important to ... divers found fossilized animal remains, bits of pottery and ... underwater cave. [Click here to see a ...
... years ago when the American Society for Cell Biology (ASCB) ... This year over 7,000 scientists from throughout the world ... Dec. 11 to 15 for ASCB,s 50th Annual Meeting. ... research on the cell, ASCB,s conferences are the largest yearly ...
Cached Biology News:Study links African ancestry to high-risk breast cancer 2Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 2Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 3Cell biology society celebrates 50th 2
(Date:9/19/2014)... 2014 Cereal grain scientists, quality ... gather October 5–8, 2014, for the AACC International ... Center in Providence, Rhode Island. The comprehensive scientific ... food scientists, chemists, microbiologists, nutritionists, and those interested ... management. To date, 1,000 attendees have registered for ...
(Date:9/18/2014)... Washington, USA (PRWEB) September 18, 2014 ... Representatives of a bill designed to stimulate development and ... jobs is being praised by leaders of SPIE, ... bill, the Revitalizing American Manufacturing and Innovation (RAMI) Act, ... The bill’s authors have said they are optimistic that ...
(Date:9/18/2014)... 2014 A novel robotic system that ... is currently being tested as part of a biomedical ... Boston with the aim of determining if the robot, ... cancer biopsies faster, more accurate, less costly, and less ... the potential to deliver prostate cancer therapies with greater ...
(Date:9/18/2014)... On Tuesday, Secretary of Energy Ernest Moniz joined ... Lab Day on the Hill. The event highlighted several ... Durbin and Risch also formally launched the Senate National ... reach of the national labs as leaders in developing ... our nation's most pressing challenges. , "The national labs ...
Breaking Biology Technology:Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3
... ATLANTA, Sept. 29, 2011 GeoVax Labs, Inc. (OTCQB/OTCBB: ... and fight Human Immunodeficiency Virus (HIV) infections, announces that ... to receive academic honors on September 26 and October ... Officer Harriet L. Robinson, PhD, was honored as a ...
... as a symbol of long-lasting love. But semiconductor makers ... of long-lasting micromachines if a new method developed at ... carving these tough, capable crystals proves its worth.* The ... in a diamond surface, yielding potential benefits in both ...
... PLC (AIM: GTL) today conducted its annual meeting in London, ... Henderson, the non-executive chairman of the U.S. based bio-refining company, ... "GTL is pleased to report that margins ... period ending September 30, 2011 closely tracked the seasonal margins ...
Cached Biology Technology:GeoVax Labs' CSO and Chairman Receive Academic Honors 2GeoVax Labs' CSO and Chairman Receive Academic Honors 3NIST polishes method for creating tiny diamond machines 2
CD69/CD3 50 tests...
PURA Immunogen: PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rat polyclonal to Vitamin B3 ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule, Vitamin B3 conjugated to BSA....
Goat polyclonal to Glucose Dehydrogenase ( Abpromise for all tested applications). Antigen: Glucose Dehydrogenase (Bacillus species)...
Biology Products: