Navigation Links
Scientists inhibit cancer gene

By studying mice with skin cancer, researchers at the Huntsman Cancer Institute at the University of Utah discovered a way to inhibit a mutant gene found in up to 30 percent of human tumors.

Called Ras, normal copies of this gene are important in cell signaling, or communication among cells. When mutated, however, Ras is an "oncogene" or cancer-causing gene that has been shown to promote the growth of cancers in the pancreas, colon and lung, as well as thyroid cancer and leukemia.

Attempts to inhibit activated Ras have had limited success until now, but the Huntsman Cancer Institute researchers explain that they have discovered an enzyme that, when inhibited, appears to reduce the incidence of Ras-induced tumors in mice.

They reported their findings in the May 9 - 13, 2005, issue of the journal Proceedings of the National Academy of Sciences Online Early Edition.

Matthew K. Topham, M.D., assistant professor of internal medicine at the University of Utah School of Medicine and lead investigator on the study, explains that the research team had originally been testing a group of enzymes that regulate the function of the Ras gene. These enzymes, called diacylglycerol kinases (DGKs), are implicated in tumor growth.

"When we began our investigation using a type of DGK, called DGK iota, we thought that its absence would cause more tumors to develop, as has happened with other DGKs we have tested. This time, though, when we tested mice with an activated Ras gene, but an absent DGK iota gene, the number of tumors was significantly reduced," Topham says. "This result is interesting, because it happened when the Ras gene was activated. The implication is that a drug therapy could be developed to reduce tumors caused by Ras without significant side effects."

The research team also included Huntsman Cancer Institute scientists Debra Regier, Ph.D.; Jared Higbee; Katrina Lund; Fumio Sakane, Ph.D.; and Stephen M. Prescott, M.D., profe
'"/>

Source:Huntsman Cancer Institute, University of Utah Health Sciences Center


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists inhibit cancer gene

(Date:2/9/2010)... have identified a gene they say is a strong ... other maladies associated with the natural flux in hormones ... in the Proceedings of the National Academy of ... showing that a common human variant of the gene ... estrogen on the brain, impairing memory. If applied in ...
(Date:2/9/2010)... Calif. -- OlFactor Laboratories, Inc., a majority owned ... to patented technology from UC Riverside. , ... understanding of how two-winged blood-feeding insects, e.g. mosquitos ... detect carbon dioxide (CO2) emissions from animals and ... human and animal breath, attracts the insect to ...
(Date:2/8/2010)... and summers has been accelerating, according to a ... scientific journal Global Change Biology . ... UK research institutions, universities and conservation organisations, is ... of long-term changes in the seasonal timing (phenology) ... environments in the UK. , Led by ...
Breaking Biology News(10 mins):Research identifies gene with likely role in premenstrual disorder 2Research identifies gene with likely role in premenstrual disorder 3Will earlier springs throw nature out of step? 2Child Neurology Foundation Announces 2430 000 Grant for Research Into Cause and Treatment of Infantile Spasms 60236 1Child Neurology Foundation Announces 2430 000 Grant for Research Into Cause and Treatment of Infantile Spasms 60236 2Child Neurology Foundation Announces 2430 000 Grant for Research Into Cause and Treatment of Infantile Spasms 60236 3Elekta Demonstrates Continued Leadership in Image Guidance at 2009 ASTRO Annual Meeting 5785 1Elekta Demonstrates Continued Leadership in Image Guidance at 2009 ASTRO Annual Meeting 5785 2Elekta Demonstrates Continued Leadership in Image Guidance at 2009 ASTRO Annual Meeting 5785 3Elekta Demonstrates Continued Leadership in Image Guidance at 2009 ASTRO Annual Meeting 5785 4SMU geothermal conference 10556 1SMU geothermal conference 10556 2
... Mayo Clinic researchers report that the expression of two novel ... cancer may allow identification of women who are and are ... Results of the study are published in the April 1 ... gene profile was previously discovered as a potential marker of ...
... new method of delivering chemotherapy to cancer patients without incurring ... developed. , The method, produced at the University of ... the chemotherapy drug which are then implanted into the cancerous ... and compatible with body tissue, which means they would not ...
... A potentially ground-breaking treatment for nerve damage caused by ... patient trials. , The University of Manchester team has ... by stimulating a person's genes may prevent nerve damage ... disease. , The positive preclinical results ?reported in the ...
Other Biology News:Mayo Clinic study finds two genes predict outcome for breast cancer patients 2New device could cut chemotherapy deaths 2Trial success for diabetic nerve therapy 2
(Date:2/5/2010)... PARK, Md. -- University of Maryland researchers have ... computational techniques to analyze patterns of improvised explosive ... locations and predict the locations of weapons caches ... attacks. , University of Maryland computer science Ph.D. ... Subrahmanian, together with University of Torino (Italy) computer ...
(Date:2/5/2010)... Cardiovascular Disease ,, COLLEGE PARK, Md. ... Life Inc. ( www.renovalife.com ), a company developing ... has joined the Maryland Technology Enterprise Institute (Mtech) ... today. ,, The privately funded company, founded in ... month. ,, "The most important factors [for joining ...
(Date:2/5/2010)... -- Transgenomic, Inc. (OTC Bulletin Board: TBIO) today announced ... Officer, will be presenting a corporate overview of the ... Conference. Transgenomic,s presentation will take place at 11:30 ... at The Waldorf- Astoria in New ... Inc. ,, Transgenomic, Inc. (OTC BB: ...
(Date:2/5/2010)... CRANBURY, N.J. , Feb. 5 ... its Board of Directors has elected John F. ... to his current role as Chief Executive Officer (CEO), ... Hayden, Jr. , who will become the Lead Independent ... elect Mr. Crowley as Chairman of the Board reflects ...
Breaking Biology Technology:'Fighting' IED attacks with SCARE technology 2'Fighting' IED attacks with SCARE technology 3Renova Life Inc. Joins Mtech Incubator 2Renova Life Inc. Joins Mtech Incubator 3Transgenomic Presents at 12th Annual BIO CEO & Investor Conference 2Amicus Therapeutics Board of Directors Names Chief Executive Officer John F. Crowley Chairman of the Board 2
... Wauwatosa, Wis. - A Medical College of Wisconsin ... to study salt-sensitive high blood pressure. , ,The grant was ... to evaluate the impact that genes within specific regions ... kidney failure. According to the institute, high blood pressure, also ...
... Corp. , a $6 billion-a-year information technology product and services ... the stock of Madison-based Berbee Information Networks Corp. ... has been approved by the boards of both companies, is ... regulatory approvals and approval by Berbee shareholders. , ,Berbee, which ...
... knows the University of Wisconsin-Madison stimulates the ... new study has produced figures to back that assertion. ... University Research Park , located three miles west ... And the concentration of these innovative firms, according to ...
Other Biology Technology:Medical College receives $11 million grant to study high blood pressure 2Berbee believes acquisition by CDW will make it a national IT player 2Berbee believes acquisition by CDW will make it a national IT player 3Impact of research park firms pegged at $680M 2
... and efficient method for purification of DNA fragments ... fragments selectively absorbed in the spin column after ... room temperature for PCR product with equal volume ... DNA can be purified with a single prep ...
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human HLA-DR TAC is designed to deplete human HLA-DR from samples to isolate resting CD4+ or CD8+ T cells....
Fujifilm BAS-1800II provides the ideal configuration for a low-cost imager that requires only a small amount of space in the laboratory. The small imager for accurate high-throughput screening...
Request Info...
Biology Products: