Navigation Links
Scientists inhibit cancer gene

By studying mice with skin cancer, researchers at the Huntsman Cancer Institute at the University of Utah discovered a way to inhibit a mutant gene found in up to 30 percent of human tumors.

Called Ras, normal copies of this gene are important in cell signaling, or communication among cells. When mutated, however, Ras is an "oncogene" or cancer-causing gene that has been shown to promote the growth of cancers in the pancreas, colon and lung, as well as thyroid cancer and leukemia.

Attempts to inhibit activated Ras have had limited success until now, but the Huntsman Cancer Institute researchers explain that they have discovered an enzyme that, when inhibited, appears to reduce the incidence of Ras-induced tumors in mice.

They reported their findings in the May 9 - 13, 2005, issue of the journal Proceedings of the National Academy of Sciences Online Early Edition.

Matthew K. Topham, M.D., assistant professor of internal medicine at the University of Utah School of Medicine and lead investigator on the study, explains that the research team had originally been testing a group of enzymes that regulate the function of the Ras gene. These enzymes, called diacylglycerol kinases (DGKs), are implicated in tumor growth.

"When we began our investigation using a type of DGK, called DGK iota, we thought that its absence would cause more tumors to develop, as has happened with other DGKs we have tested. This time, though, when we tested mice with an activated Ras gene, but an absent DGK iota gene, the number of tumors was significantly reduced," Topham says. "This result is interesting, because it happened when the Ras gene was activated. The implication is that a drug therapy could be developed to reduce tumors caused by Ras without significant side effects."

The research team also included Huntsman Cancer Institute scientists Debra Regier, Ph.D.; Jared Higbee; Katrina Lund; Fumio Sakane, Ph.D.; and Stephen M. Prescott, M.D., profe
'"/>

Source:Huntsman Cancer Institute, University of Utah Health Sciences Center


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists inhibit cancer gene

(Date:4/23/2014)... hungry diner ripping open a dinner roll, a fuel ... open a hydrogen molecule. Now researchers have captured a ... halves of its hydrogen feast. The view confirms previous ... catalyst work better for alternative energy uses. , This ... where the hydrogen halves end up in the structure ...
(Date:4/23/2014)... a unique rhythmic sound, recorded for decades in the ... minke whale ( Balaenoptera bonaerensis ). First described and ... it sounded like a duck, the bio-duck sound has ... but its source has remained a mystery, until now. ... deployed acoustic tags on two Antarctic minke whales in ...
(Date:4/23/2014)... in Buenos Aires yesterday, Argentina joins the European ... state. The move strengthens the ties between the ... grants Argentinian scientists access to EMBL,s world-class facilities ... "Ever since its inception, fostering excellent life science ... the core of EMBL,s mission," says EMBL Director ...
Breaking Biology News(10 mins):Halving hydrogen 2Halving hydrogen 3Halving hydrogen 4Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3
... of mold and other causes of Sick Building ... with The American Phytopathological Society (APS). , Sick ... which building occupants experience health problems while inside ... with SBS range from allergy attacks and asthma ...
... and taking in nutrients, plant roots secrete a ... roots, as well as insects and microbes. But ... has not been extensively investigated—until now. Using the ... cabbage, Jorge Vivanco and co-workers at Colorado State ...
... earliest cities in northern China starting as far back ... successful rice farming combined with other crops, says University ... associate rice with Chinese agriculture, most archeologists have, until ... most important food associated with northern China. However, recent ...
Cached Biology News:What's really making you sick? Plant pathologists offer the science behind Sick Building Syndrome 2Roots Engage in Underground Chemical Warfare 2
(Date:1/15/2014)... January 15, 2014 Cynvenio, a cancer ... through the genomic analysis of tumor cells in the ... a web-based cancer decision support application powered by CollabRx, ... Cynvenio’s ClearID™ genomic test, Therapy Finder will provide breast ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Two champions ... continued their sponsorship of an annual competition for middle ... and access to, innovative STEM study. The competition presents ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... 15, 2014 2013 was a banner ... State Technologies®. They saw continued independent research led by ... were awarded a $1 million grant from the Susanne ... and Behavior” a peer reviewed journal, Amy Grant highlighted ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Nov. 12 AvidBiotics Corp. announced the issuance ... for generating massive diversity within precisely targeted sites ... is referred to as Diversity Generating Retroelements (DGR) ... States (#7,585,957) and in Europe (#1,173,995). UCLA ...
... Nov. 12 /PRNewswire-FirstCall/ - BioMS Medical Corp. (TSX: MS) ... and nine months ended September 30, 2009. , During ... BioMS Medical and Eli Lilly and Company (NYSE: LLY) ... commercial rights to dirucotide are returned to BioMS. , ...
... 12 Regado Biosciences, a privately held company leading ... announced that David Mazzo, PhD, CEO and President, will ... Healthcare Conference at the St. Regis Hotel in New ... 1:10pm (EST) on Tuesday, November 17 and will include ...
Cached Biology Technology:AvidBiotics Corp. Granted Key U.S. and European Patents on Unique Protein Modification Platform 2BioMS Medical Announces Third Quarter 2009 Results 2BioMS Medical Announces Third Quarter 2009 Results 3BioMS Medical Announces Third Quarter 2009 Results 4BioMS Medical Announces Third Quarter 2009 Results 5BioMS Medical Announces Third Quarter 2009 Results 6BioMS Medical Announces Third Quarter 2009 Results 7BioMS Medical Announces Third Quarter 2009 Results 8Regado Biosciences to Present at the Lazard Capital Markets 6th Annual Healthcare Conference on November 17, 2009 2
... ml Dynabeads Mouse pan B (B220), ... antibody. For the efficient positive isolation ... directly from spleen or lymph node ... on mouse B cells and lytically ...
POU domain, class 2, transcription factor 2,...
IKKbeta/IKK-2 Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Reacts with human. Tested in Western blotting....
1, 2 or 8 PreMixes are included as part of the FailSafe™ PCR System....
Biology Products: