Navigation Links
Scientists identify prion's infectious secret

of tiny protein fragments. Traditionally, these arrays are used for finding binding sites within well-behaved proteins. Here, Tessier designed the arrays so that he could observe protein folding and amyloid formation in real time.

Tessier covered the array with peptides from baker’s yeast and then added prion protein to the array, also from the same yeast species. He found that a small cluster of peptides recruited the prion proteins to misfold into an amyloid structure. This region of the protein, which Tessier called a "recognition element," constitutes about 10 percent of the prion. Tessier repeated this experiment with peptides and a prion taken from pathogenic fungi. The results were the same.

Both prions also maintained a rigid species barrier. The baker’s yeast prion could not recruit peptides from the pathogenic fungi cells, and vice versa.

To further verify these results, Tessier accessed a synthetic yeast prion, one that another research group had assembled from pieces of both the baker’s yeast and the pathogenic fungi prion. Earlier studies had shown that this synthetic prion could cross the species barrier but did not identify the mechanism. Tessier found that this synthetic prion contained two recognition elements, one for baker’s yeast and one for pathogenic fungi. When the prion was placed with peptide fragments from baker’s yeast, the baker’s yeast recognition element was activated, and likewise for the pathogenic fungi.

Even more striking, Tessier could activate different recognition elements by manipulating environmental conditions, such as temperature. For example, when he conducted the experiment at 4 degrees Celsius, the baker’s yeast recognition element switched on. At 37 degrees Celsius, the pathogenic fungi element was activated. In other words, temperature alone could dictate which yeast species the prion could infect. Additionally, the prion’s behavior could be altered by subtle alterations in th
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists identify prion infectious secret

(Date:7/31/2015)... SHENZHEN, China , 31 de julho de 2015 ... Genômica (ICG-10, www.icg-10.org ) será realizada pela BGI de ... China . A conferência está ... inauguração em 2006, a ICG se tornou uma das ... e um dos encontros científicos mais dinâmicos, entusiastas e ...
(Date:7/31/2015)... --NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market and creator of the Wocket® smart ... for ELECTRONIC CRYPTO-CURRENCY MANAGEMENT METHOD AND SYSTEM ... crypto-currencies such as Bitcoin into the consumer market of ... manage all payments.  The technology manages ...
(Date:7/27/2015)... 2015   Zynx Health ™, the market ... solutions, today announced that its ZynxCarebook ™ ... Android smartphones and tablets. With this expansion, care ... use ZynxCarebook to securely exchange messages and share ... transitions to other care settings, and improve clinical ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3
... Jan. 6, 2011 Acceleron Pharma, Inc., a biopharmaceutical ... cells and tissues including muscle, bone, fat, red blood ... awarded a $1.5 million grant from the Muscular Dystrophy ... Muscular Dystrophy (DMD), a disabling neuromuscular disease in which ...
... that nations should abandon the concept of carbon emissions ... might lead to genuine reductions in the amount of ... provide a mechanism for reducing climate change. Details of ... Interdisciplinary Environmental Review . Carbon emissions trading ...
... The number of women who die from complications of ... last two decades thanks to improved monitoring and better ... report,s lead researcher, Joy Hawkins, MD, professor of anesthesiology ... Colorado School of Medicine, said the risks have been ...
Cached Biology News:Acceleron awarded $1.5 million grant from Muscular Dystrophy Association to support ACE-031 2Carbon swap bank to beat climate change 2Carbon swap bank to beat climate change 3Deaths from anesthesia during childbirth plummet 2
(Date:7/31/2015)... 2015 In today,s fast changing healthcare ... drive positive health outcomes, improve profitability and enhance ... care in their communities. At ThoughtSpot 2015, ... AmerisourceBergen announced a new set of innovative capabilities ... and help independent pharmacies endure the industry,s most ...
(Date:7/30/2015)... ... July 31, 2015 , ... Ralco is honored to announce that it ... Fair to be held August 5-9 in Marshall. The Ralco Enrichment Center is an ... and how agriculture impacts their daily lives. This unique exhibit also features a birthing ...
(Date:7/30/2015)... ... ... The 2015 Market Research Report on the Global Propanol Industry ... market with a focus on the Chinese situation. Major companies included in the propanol ... Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , The report provides ...
(Date:7/30/2015)...   Senomyx , Inc. (NASDAQ: SNMX ), ... discover, develop, and commercialize novel flavor ingredients for the ... results for the second quarter 2015. ... on track to achieve our commercial and financial goals," ... the Company. "Since our last quarterly earnings report, our ...
Breaking Biology Technology:AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9
... /Xinhua-PRNewswire-FirstCall/ -- 3SBio Inc.,(Nasdaq: SSRX ), a ... and marketing biopharmaceutical,products, today announced its unaudited financial ... Second Quarter 2008 Financial Highlights: ... second quarter 2007 to ...
... To protect potential patients from,being unwitting victims in ... Stem Cell Institute LLC (RSCI),( http://www.RepairStemCells.org ) and ... of the industry,s first standards of,excellence for Repair ... RSC, also known as Adult Stem Cells. Among ...
... on Monday, August 18, 2008, ... Beginning at 1:00 PM Eastern Time, LIVINGSTON, N.J., Aug. ... in,advanced injection technologies, today announced that it plans to report,its results ... the morning,of Thursday, August 14, 2008., Milestone Scientific will also ...
Cached Biology Technology:3SBio Inc. Announces Second Quarter 2008 Results 23SBio Inc. Announces Second Quarter 2008 Results 33SBio Inc. Announces Second Quarter 2008 Results 43SBio Inc. Announces Second Quarter 2008 Results 53SBio Inc. Announces Second Quarter 2008 Results 63SBio Inc. Announces Second Quarter 2008 Results 73SBio Inc. Announces Second Quarter 2008 Results 83SBio Inc. Announces Second Quarter 2008 Results 93SBio Inc. Announces Second Quarter 2008 Results 103SBio Inc. Announces Second Quarter 2008 Results 113SBio Inc. Announces Second Quarter 2008 Results 123SBio Inc. Announces Second Quarter 2008 Results 133SBio Inc. Announces Second Quarter 2008 Results 143SBio Inc. Announces Second Quarter 2008 Results 15Repair Stem Cell Institute Announces Industry's First Standards of Excellence for Global Stem Cell Treatment Centers to Protect Patients from Less-than-Competent Therapeutics 2Milestone to Report Results for 2008 Second Quarter on Thursday, August 14, 2008 2
... Measurement of light production by luciferase-cDNA ... a valuable technique in the development of ... is used as an indicator for the ... the luciferase enzyme is due to advantages ...
... detection of apoptosis and mitochondrial membrane potential. ... early indication of the initiation of cellular ... a collapse in the electrochemical gradient across ... change in the membrane potential (YD). Loss ...
... kit measures mitochondria intactness and detects ... potential. Features and Benefits: ... staining isolated mitochondria and for assaying ... the reagents required for the detection ...
... is expressed in g per ml and is ... pH 6.8, of a 1 mg per ml ... concentration to agglutinate a 2% suspension of human ... at 25 C. Preparation Note: Affinity ...
Biology Products: