( kt-mediated cell survival writes Dr. ...)Scientists identify molecule that regulates well-known tumor suppressor

The authors go on to suggest that DJ-1 may be a prognostic marker for cancer patients and be useful as a target for development of future cancer therapeutics. Interestingly, DJ-1 may play a role in other disease states, as it has also been recently identified as a predictive diagnostic for early-onset, autosomal recessive Parkinson's disease.

The other members of the research team include Raymond H. Kim, YingJu Jang, and Tak W. Mak of Ontario Cancer Institute and University of Toronto; Malte Peters, Carmela DeLuca, Jennifer Liepa, Lily Zhou, and Bryan Snow of Ontario Cancer Institute; Wei Shi, Richard C. Binari, and Armen S. Manoukian of University of Toronto; Melania Pintilie of Princess Margaret Hospital; Graham C. Fletcher and Mark R. Bray of Miikana Therapeutics Inc.; and Fei-Fei Liu and Ming-Sound Tsao of University of Toronto and Princess Margaret Hospital. The researchers are supported by the Canadian Cancer Society, the National Cancer Institute of Canada, Frank Fletcher Memorial Fund, David Rae Scholarship, Paul Starita Fellowship, and Canadian Institutes of Health Research.

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Raymond H. Kim, Malte Peters, YingJu Jang, Wei Shi, Melania Pintilie, Graham C. Fletcher, Carmela DeLuca, Jennifer Liepa, Lily Zhou, Bryan Snow, Richard C. Binari, Armen S. Manoukian, Mark R. Bray, Fei-Fei Liu, Ming-Sound Tsao, and Tak W. Mak: "DJ-1, a novel regulator of the tumor suppressor PTEN"

Publishing in Cancer Cell, Volume 7, Number 3, March 2005, pages 263-273. http://www.cancercell.org