Navigation Links
Scientists identify genetic pathways essential to RNA interference

A research team based at Massachusetts General Hospital (MGH) has identified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will appear in the journal Science and is receiving early online release on the Science Express website at http://www.sciencexpress.org.

"The gene activation produced by RNAi is exquisitely specific, which gives it enormous potential for therapeutic application," says Gary Ruvkun, PhD, of the MGH Department of Molecular Biology, the study's senior author. "Imagine short, double-stranded RNA molecules that could be synthesized quickly and inexpensively to silence a single gene. Promising targets could include viruses like HIV and hepatitis C or cancer-causing oncogenes. An RNAi-based treatment for age-related macular degeneration is already in clinical trials." Ruvkun is a professor of Genetics at Harvard Medical School.

RNAi was originally identified in the C. elegans roundworm and the flowering plant Arabidopsis thaliana, both of which are common model organisms for biological research. The process interrupts the usual transfer of instructions from double-stranded DNA, through single-stranded messenger RNA and finally into proteins. Short, double-stranded pieces of RNA bind to the complementary messenger RNA segments, shutting down gene expression. RNAi occurs naturally in plants and animals and may help control resistance to viral infection, among other functions.

For the current study, lead author John Kim, PhD, and his colleagues developed a strain of C. elegans into which they added a gene that caused the worms to glow under ultraviolet light but also turned that gene off using RNAi. They then used RNAi to inactivate every one of the worms' 19,000 genes by feeding the
'"/>

Source:Massachusetts General Hospital


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
(Date:12/5/2014)... -- Tute Genomics, a leader in cloud-based solutions for genome ... led by UK-based Eurovestech. Peak Ventures and a number ... "We are at a pivotal time in ... seeks new approaches for the diagnosis, treatment and prevention ... and CEO of Tute Genomics. "One of the main ...
(Date:12/3/2014)... 2014   Marvin Test Solutions , a ... for military, aerospace, and manufacturing organizations, today announced ... TS-900 PXI semiconductor test platform . The ... systems to customers at a fraction of the ... ATE. "Our semiconductor customers asked ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... Methanosarcina acetivorans lives off everything it can metabolize ... is not yet clear. Scientists at the Ruhr-Universitt Bochum ... USA have identified a protein that might act as ... and found both similarities and differences to the system ...
... animal research published in Biological Psychiatry suggests ... learning that is important clinically. Selective serotonin reuptake ... widely used to treat depression, as well as a ... drugs on learning and memory are poorly understood. ...
... In India most people who are HIV positive don,t ... available. It would therefore meet international standards of cost-effectiveness ... every person in the billion-plus population every five years according ... One . The findings are based on a careful ...
Cached Biology News:How Archaea might find their food 2Do antidepressants impair the ability to extinguish fear? 2Cost-effective: Universal HIV testing in India 2Cost-effective: Universal HIV testing in India 3Cost-effective: Universal HIV testing in India 4
(Date:12/19/2014)... Today, TiFiber, Inc. announced ... and future company headquarters in Fort Smith, Arkansas ... that safely and effectively control dangerous microorganisms. Fort ... historic, strong support for manufacturing, but also due ... technology-based companies such as TiFiber. , In ...
(Date:12/19/2014)... In contrast to traditional LED lights where ... Valoya uses proprietary LED technology to incorporate their spectra ... which is critical in low proximity installations. The Valoya ... its lifetime which is up to four times longer ... investment cost was clearly higher when compared to traditional ...
(Date:12/19/2014)... , Dec. 18, 2014   ISN ... & Safety Performance Indicators publication series. With ... of activity reported in 2013 within its online contractor ... and safety key performance indicator (KPI) statistics. ... Clients, U.S. publication is available in two ...
(Date:12/17/2014)... TX (PRWEB) December 17, 2014 Achim ... and administration for Stoller Group. In this position, Noack ... Group, on administrative matters, develop marketing strategy and supervise ... services. , “Achim has tremendous knowledge and experience ... of Stoller Group. “His experience and innovative thinking will ...
Breaking Biology Technology:Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
... Oncology Inc., a molecular diagnostics company specializing in ... for gynecologic cancer, announced today that it has ... The Moffitt Cancer Center, the only National Cancer ... agreement provides OvaGene with exclusive worldwide rights to ...
... Codexis, Inc. (Nasdaq: CDXS ) today ... and Chief Marketing Officer.  In this new position, Mr. ... and communications.  He will report to Alan Shaw, Ph.D., ... is a widely recognized marketing executive in the global ...
... Dec. 2, 2011  Immune Design Corp. announced today ... as its new Chief Development Officer.  Dr. Gombotz ... to this key leadership position at Immune Design. ... Immune Design,s therapeutic vaccine product candidates. ...
Cached Biology Technology:OvaGene Oncology Collaborates With Moffitt Cancer Center to Develop and Commercialize microRNAs Associated With Chemotherapeutic Drug Response 2OvaGene Oncology Collaborates With Moffitt Cancer Center to Develop and Commercialize microRNAs Associated With Chemotherapeutic Drug Response 3Codexis Names Wes Bolsen VP and Chief Marketing Officer 2Immune Design Corp. Appoints Wayne R. Gombotz, Ph.D. as Chief Development Officer 2
... Many modifications of Eagle's medium ... original formulation. The most widely ... Eagle's,Medium. DME is a modification ... [MEM] that contains a higher ...
... The EpiTect Bisulfite Kit enables ... uracils in less than 6 hours. ... innovative protection against DNA degradation and ... to guarantee fast and reliable results ...
Rabbit polyclonal antibody to Glutathione-S-Transferase (GST)...
... gold standard for automated bioresearch: Developed ... applications • Based on decades of ... accessories designed for bioresearch • Holographic ... Versatility, reliability and ease-of-use • Pulsed ...
Biology Products: