Navigation Links
Scientists identify gene involved in stem cell self-renewal in planaria

No matter how you slice it, the freshwater planarian possesses an amazing ability to regenerate lost body parts. Chop one into pieces, and each piece can grow into a complete planarian. The flatworm relies upon a population of stem cells to accomplish this remarkable feat; recent work sheds light on how planarians maintain these stem cells throughout their lives.

In a paper to appear in the August issue of the journal Developmental Cell, scientists show that a member of the Bruno-like family of RNA binding proteins ?produced by a gene found in both planarians and humans ?plays a vital role in maintaining the stem cell population in the planarian Schmidtea mediterranea. The work could lead to a better understanding of the fundamental mechanisms by which stem cells are regulated; such basic understanding is required for the successful therapeutic application of stem cells in humans.

"One of the defining characteristics of stem cells is their ability to self-renew ?that is, to make more stem cells in addition to differentiating into multiple cell types," said Phillip A. Newmark, a professor of cell and developmental biology at the University of Illinois at Urbana-Champaign and corresponding author of the paper. "We found that in the absence of this protein, the stem cells could respond to wound stimuli, proliferate, and differentiate, but they were unable to self-renew. As a result, the regeneration process failed and the animals died."

Using a technique called RNA interference, Illinois graduate student Tingxia Guo and Newmark first eliminated most of the Bruno-like protein (Bruli) from a number of planarians. Then they amputated a small piece from each flatworm.In the usual manner, the planarian stem cells migrated to the site of the wound, sensed what was missing and began rebuilding. Regeneration ceased, however, when the stem cell population became depleted.

"Had Bruli protein been present, the regeneration process would have conti nued to completion," Newmark said. "What may be happening is that when this protein is eliminated, RNAs that are supposed to be turned off (that is, not made into proteins) are now turned on and made into proteins. Those proteins may then cause the stem cells to differentiate, instead of also producing new stem cells to maintain the population."

While there is still much to be learned about stem cell self-renewal, the researchers' results suggest that Bruli protein is required for stem cell maintenance in planarians.

"The next steps are to see if the gene that makes this protein in planarians plays a similar role in stem cells in other organisms and to identify possible RNA targets of this protein," Newmark said.


'"/>

Source:University of Illinois at Urbana-Champaign


Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys ... founding CEO, Barrett Bready , M.D., who returned ... of the original technical leadership team, including Chief Technology ... of Product Development, Steve Nurnberg and Vice President of ... to the company. Dr. Bready served as ...
(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
(Date:3/22/2016)... and SANDY, Utah , March ... operates the highest sample volume laboratory in ... and UNIConnect, leaders in clinical sequencing informatics and molecular ... of a project to establish the informatics infrastructure for ... NSO has been contracted by the Ontario Ministry ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , ... June 27, 2016 , ... ... bring innovative medical technologies, services and solutions to the healthcare market. The company's ... of various distribution, manufacturing, sales and marketing strategies that are necessary to help ...
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial ... Cary 5000 and the 6000i models are higher end machines that use the more ... the spectrophotometer’s light beam from the bottom of the cuvette holder. , FireflySci ...
Breaking Biology Technology: